OBJECTIVE: To investigate the characteristics and general pattern of the adverse drug reactions (ADR) occurred in our hospital. METHODS: A total of 113 ADR cases reported by our hospital in 2008 were analyzed statistically in respect of patients’age and sex, route of administration, dosage form, category of drug, organs and systems involved in ADR and clinical manifestations, etc. RESULTS: The ADR were mainly induced by venous administration (59.29%). Anti-infective drugs dominated the first place on the list of ADR incidence rate (46.90%) followed by TCM preparations (23.01%). The most common manifestation of the ADR was lesion of skin and its appendants(37.17%). CONCLUSION: Great importance should be attached to ADR monitoring to reduce or avoid the occurrence of ADR.

The writer discussed the features of modern relationship between hospitals & patients and the main factor which cause the irreconcilable relationship,and also points out the way of setting up normal relationship between hospitals & patients,furthering the medical reform,normalizing the medical performances,improving the medical service quality,ceteing up and perfecting the related laws and cstrenghening the cultivation and education for medical stndent etc.

Through investigation that the “new network media” has become the partner of youth groups firstly , then this paper discussed the new trend of medical students in new network era , including:paying attention to so-cial trends , thinking of something but without deep thinking;main body values is good , but diversity values show obvious;mental strength weakening presents a variety of forms .In the final analysis how the ideological education in the new era of network breakthrough:to strengthen the construction of campus network , to lead healthy campus culture;establish a network ideological education platform;perfect the network psychological consultation platform , to strengthen medical students′psychological health education; strengthen the student party members and cadres network call .

0.05). Compared with controlled central venous pressure (CVP) before and right after hepatectomy, CVP increased significantly (P

Objective To investigate the effect of exception questions/miracle questions in SolutionFocused Approach in nursing on affects,confidence to solve problem,the perception of problem's difficulty,and actual solving problems,to provide practical basis for practitioners of Solution-Focused Approach.Methods A total of 102 nurses were randomly divided into exception questions in Solution-Focused Approach group (exception group),miracle questions in Solution-Focused Approach group (miracle group)and cause questions in the traditional psychotherapy pattern group(cause group).The difference among three groups on the aspect of the change of affects,confidence to solve problem and the perception of problem's difficulty,and the help form the questions immediately and after 1 week (immediate help and 1 week after help) were studied.Results Eventually subjects effectively,34 nurses in exception group,31 nurses in miracle group,31 nurses in cause group.The difference among three groups in aspect of the change of affects,the change of confidence to solve problem,immediate help and 1 week after help were statistically significant (Z=9.68-18.58,P＜ 0.05).Furthermore,change in problem solving confidence on exception group was higher than cause group(51.9 vs.35.6,P ＜ 0.05),change in affects on exception group and miracle group were higher than cause group (53.8,55.1 vs.36.0,P ＜ 0.05),the immediate help on exception group and cause group were higher than miracle group (59.8,52.5 vs.32.0,P ＜ 0.05),and 1 week after help on exception group was higher than miracle group and cause group(64.5 vs.42.3,37.0,P ＜ 0.05).Conclusions Exception/miracle questions can both improve the emotional state,and exception questions can enhance the confidence to solve problems and provide more help for nurses.

Embryonic stem cells undergo extensive self-renewal and have the capacity to differentiate along multiple cell lineages.Research on totipotency and directional differentiation of embryonic stem cells in order to treat intractable disease,such as cancer,heart failure,atherosclerosis by tissue regeneration and cell transplantation are investigated.Epigenetic modification,including DNA methylation,chromatin restructure,and non-coding RNA-mediated regulatory events,regulate the differentiation of embryonic stem cells without detectable genetic changes.These mechanisms are often associated with starting-up and maintenance of epigenetic silence.The achievement and focuses on the molecular mechanism of embryonic stem cells during directional differentiation regulated by epigenetic modification are reviewed.

Objective To study the therapeutic effects of blood component transfusions on acute leukemia complicated with DIC.Methods The blood component transfusions were mainly used to treat 11 patients with acute aranulocytic leukemia and acute lymphatic leukemia complicated with DIC.Results Three cases were cured,one case were obviously effective,two were improved and five were ineffective,which the total effective rate was 54 5% .Conclusion Early diagnosis and blood component transfusions in timely are effective methods to treat the acute leukemia patients complicated with DIC

Objectives The aim of this study was to study the relationship between silent cerebral ischemia (SCI) and mild cognitive impairment(MCI)in inpatients with nonvalvula atrial fibrillation (NAF) and those with sinus rhythm (SR) older than sixty. Methods Ninety-eight inpatients were enrolled from November 2014 to November 2015 in Hui?zhou Municipal Central Hospital: 45 patients with NAF and 53 with SR. All general clinical data was collected. The Montreal Cognitive Assessment (MoCA) and brain MRI were used to assess the cognitive performance of patients within 1 weeks of admission. Results The MoCA scores were lower in patients with NAF than in those with SR[16(10,20) vs. 20 (15,23),P=0.006]. At least one foci of SCI was present in patients 80%with NAF and 52.8%with SR (NAF vs. SR, P=0.018).The rates of SCIs in the cortex/subcortex were higher in the NAF group than in the SR group (25.2%vs. 12.4%, P=0.017). Multivariate analysis showed that MoCA score were related to the degree of education in NAF patients and were related to age and education level in SR patients. Conclusions NAF is an independent risk factor for cognitive impair?ment in NAF patient and associated with the SCI present. Educational level is a factor affecting the cognitive function with elderly patients.

OBJECTIVE:To establish phenol-sulfuric acid method for the determination of the content of total polysaccharides in Weile granules.METHODS:The samples were deproteinized by Sevag method,colored by phenol-sulfuric acid method(water bath at 60 ℃ for 30 min),and the content of total polysaccharides in Weile granules was determined with Glucose as control.RESULTS:The linear range of Glucose was 20.47～102.36 ?g?mL-1(r=0.999 4),with an average recovery of 99.09%(RSD=0.92%,n=6).The content of total polysaccharides in Weile granules was 41.63%.CONCLUSION:This method was simple,accurate and reproducible,and suitable for quality control of Weile granules.

AIM:To study the effects of ischemic postconditioning(PC) on regional cerebral blood flow(rCBF) and astrocyte(AS) activation in hippocampus CA1 area and to explore the possible mechanism of ischemic PC affecting glial fibrillary acidic protein(GFAP) expression during focal cerebral thrombosis.METHODS:The thrombotic focal cerebral ischemia was induced by photochemical reaction in tree shrews,and ischemic postconditioning was established by cliped ipsilateral carotid of the animal at 4 h after cerebral ischemia.The rCBF and GFAP expressions in hippocampus CA1 area were detected,respectively,by laser-Doppler(LD) fowmeter and immunohistochemistry.RESULTS:The numbers of GFAP positive cells were increased markedly and GFAP expression enhanced(P