Objective To investigate correlational study on the levels of homocysteinin with the severity of coronary artery in patients with coronary atherosclerotic disease.Methods 60 patients with coronary atherosclerotic disease were enrolled in from Janu-ary 2013 to December 2014 in Beijiao hospital affiliated Southern medical university .All patients received coronary artery angiograph and the levels of circulating homocysteinin were determined.According to the levels of circulating homocysteinin, 60 patients were de-vided into coronary atherosclerotic disease group and coronary atherosclerotic disease group with hyperhomocysteinemia ( HHcy) .The levels of homocysteinin and the severity of coronary artery in patients with coronary atherosclerotic disease and correlation between the two group were analyzed.Results Compared with coronary atherosclerotic disease patients,the levels of homocysteinemia and Genisi score were increased in patients with coronary atherosclerotic disease with HHcy (p<0.05).Correlation analysis showed that the lev-els of homocystein is positively correlated with Genisi score (p<0.05).Conclusion HHcy is a important risk for coronary athero-sclerotic disease and positively related with the severity of coronary artery in patients with coronary atherosclerotic disease .

Objective To investigate the levels of homocysteinin and neutrophil gelatinase associated lipocalin and its rela-tionship in patients with chronic heart failure combined insufficient renal function .Methods 58 patients with chronic heart failure were enrolled in from June 2013 to June 2014 in Beijiao hospital affiliated Southern medical university .Thereinto, according to pa-tient’s condition, 28 patients were chronic heart failure concurrence insufficient renal function, 30 patients were chronic heart failure. Left ventricular ejection fraction were determined by cardiac ultrasound , the levels of serum BNP, Hcy, NGAL and creatine were de-termined.Results Compared with chronic heart failure patients,the levels of Hcy and NGAL were increased in patients with chronic heart failure concurrence insufficient renal function (p<0.05).Correlation analysis showed that the levels of Hcy is positively corre-lated with the levels of NGAL (p<0.05);the levels of Hcy and NGAL were positively correlated with BNP and creatine (p<0.05), but negatively correlated with LVEF (p<0.05), respectively.Conclusion Circulating levels of Hcy and NGAL can reflect the de-velopment of chronic heart failure concurrence insufficient renal function .

After signs of risk have been happened in risk management of medical equipment at present, reports are taken step by step. So there is a report not timely, incomplete information, it is difficult to monitor, and many other problems. With the improvement of risk management requirements; the development of the information technology s apply, and increasing sources of information used for risk early warning analysis. This paper analyzes the requirement of risk management, and proposes a total solution of enterprise risk early warning based on EAI. It will make managers accurately and fully grasp the risks, find risk signs timely, speed up the response to risk.
Materials Management, Hospital ; Risk Management

Objective To explore the value of T wave alternans (TWA) in prediction ventricular arrhythmias in post-op TOF children. Methods The characteristics of TWA were retrospectively analyzed in 36 post-op TOF patients and 120 age-matched normal children. The relationship of sustained TWA and ventricular arrhythmias was also analysed. Results Compared with normal children, the incidence of sustained TWA was significantly increased in post-op TOF group (χ2=6.98, P<0.05). In post-op TOF patients, the incidence of ventricular arrhythmia was much higher when sustained TWA was present (χ2=10.41, P<0.05). Conclusions There exists electrophysiological basis for ventricular arrhythmia in post-op TOF children. Sustained TWA has important value in prediction of ventricular arrhythmia of post-op TOF.

BACKGROUND:In recent years, with the development of China Marrow Donor Program and the improvement of human leukocyte antigen (HLA) typing technique, novel aleles of human leukocyte antigen have been discovered constantly in China. OBJECTIVE:To identify and confirm a novel HLA alele in a Chinese individual. METHODS: A new HLA alele was found during routine human leukocyte antigen genotyping by PCR-sequence specific oligonucleotide probes and sequencing-based typing. RESULTS AND CONCLUSION:The HLA-B locus hybridization probe reaction patterns of this sample did not match with any known HLA-B aleles or alelic combinations. Exons 2, 3 were sequenced in both directions using HLA-B sequence primer and group-specific sequencing primer. The obtained sequence had 2nts change from B*07:02:01 at nt 226 and nt 228 where A->G (codon 76 ATA->GTG) and resulting in a coding change, 76 isoleucine (I) was changed to valine (V). This nucleotide sequence has been submitted to the GenBank nucleotide sequence database and it is available under the accession number HM989017. A novel HLA alele, HLA-B*07:110, was identified, and was named officialy by the WHO Nomenclature Committee.

Objective:To explore the counselor verbal response modes of psychic hot-line counseling and its characteristics.Methods:Through a qualitative study with category analysis method,8 pieces of audio recordings were collected,in each of which the entire duration was between 30 minutes to 50 minutes.And all of these record-ings were transcribed word by word.Meaningful 1202 pieces were deeply analyzed.Results:There were 5 core counselor verbal response types in hot-line counseling,greeting response,set-up response,listening response,follow-up response,and affecting response,all of which had 24 concept categories.All of the online counselors used the 5 types of verbal response.The listening response and follow-up response were the highest frequent types.Greeting response and set-up response were used mostly in the initial stage of counseling.Listening response,and follow-up response were used mostly in the stage of describing problem.Affecting response was sharply increased in the stage of analyzing problem.Greeting response and set-up response were used mostly in last stage of counseling.Conclu-sion:It suggests that there are 5 core counselor verbal response types and 24 concept categories in hot-line counse-ling.The listening response and follow-up response are the highest frequent types.Different types of verbal re-sponse modes used by counselor in different stages due to different intention.

BACKGROUND:In recent years, the use of chimeric antigen receptor modified T cells (CAR-T cells) has achieved good results in the treatment of hematological malignancies. OBJECTIVE:To summarize the CAR-T technology, and its anti-tumor mechamism, progress in the treatment of hematological malignancies as well as its safety and coping strategies. METHODS:A search of PubMed, CNKI, Wanfang by computer was performed for articles related to CAR-T published from January 2010 to January 2016, using the keywords of CAR-T in English and Chinese, respectively. RESULTS AND CONCLUSION:The main principles that CAR-T cells fight against tumors are as follows: (1) resistance to immune escape through down-regulation of MHC; (2) production of interleukin-6, -10 indirectly influences the growth of tumor cells; and (3) tumor microenvironment changes inhibit tumor growth. The use of CAR-T in the treatment of hematological malignancies has been developed by leaps and bounds in recent years. Current studies concerning B cell lymphoma mainly focus on anti-CD19 CAR-T cells that have certain therapeutic effects on acute myeloid leukemia and acute lymphoblastic leukemia. However, its safety and effectiveness have yet to be studied.

Primary hepatic carcinoma is one of the common digestive tract tumors.Surgical operation in clinic is still the most effective way to treat it so far.The caudate lobe has often been considered the forbidden zone of hepatic operation in the past due to complicated anatomy.In resent years,with the deepening of knowledge of anatomy and advanced radiological technology,many new operative approachs and operation methods have been explored to improve the situation of caudate lobectomy which is already not rare in clinic now.This article summarized the anatomy of caudate lobe and reviewed the therapy progress of the hepatic carcinomas located caudate lobe.

Monoclonal gammopathy of undetermined significances (MGUS) is a premalignant clonal disorder occurring in 4.2 ％ of adults ＞50 years old,and is associated with a 1％ risk every year of progression to multiple myeloma (MM),light-chain amyloidosis and related conditions.Differential diagnosis of asymptomatic and symptomatic monoclonal gammopathies is the determinant for starting therapy.Most patients with MGUS need frequent assessment and follow-up.A few patients with MGUS might progress into smoldering MM and symptomatic MM,or develop into light chain diseases such as AL amyloidosis and light chain deposition disease caused by M-protein,who should be followed with effective therapy.The above were in detail reviewed in the 54th American Society of Hematology (ASH) annual meetina.

Objective To evaluate the efficacy and safety of holmium laser lithotripsy in the management of cholelithiasis. Methods 17 patients with hepatolithiasis or residual stones after bile duct operation were treated by holmium lithotripsy under fibrocholedochoscope. Results 36 stones were confirmed in 17 patients by intraoperative cholangiography. 7 stones were removed directly, 24 ones by laser lithotripsy, with success rate being 82 8%(24/29). Due to located in superior segmental intrahepatic duct, other 5 stones could not be observed under fibrocholedochoscope, so they weren't treated by holmium laser lithotripsy. B ultrasoundgraphy and cholangiography showed no residual stones in extrahepatic bile duct at the 1st month postoperatively, and the untreated 5 stones were in the same place. No hemorrhage, bile leakage, liver dysfunction or other complications occurred. Conclusions Holmium laser lithotripsy under fibrocholedochoscope is an effective and safe method in the management of hepatolithiasis or residual stones after bile duct operation.