Objective To evaluated the effect of Total Glucosides of Paeony (TGP)combined with urokinase for the patients with acute cerebral ischemic stroke.MethodsA total of 152 patients with ACIS were divided into the control group (77 patients) and the observation group (75 patients) by completely randomized grouping method. Patients in the control group were treated with Urokinase by intravenous, and the observation group were treated with TGP combined with Urokinase. All patients were treated with thrombolysis treatment with in the 24 h after the exclusion of cerebral hemorrhage by brain CT and coagulation mechanism disorder. In the following 14 days, they were given the treatment of anti platelet aggregation, lowering blood lipid, trophic nerve and improving circulation. The National Institutes of Health Stroke Scale(NIHSS), the modified Rankin scale(mRS) and the daily life ability index(Barthel) were measured.ResultsThere were 28 (37.3%) patients with the NIHSS scores decreasing 4 points in observation group and 12 (15.6%) in control group after treatment of 7 days,and there was significant difference between two groups (χ2=8.181,P=0.004). There were 68 (90.7%) patients with mRS score less than 4 points in observation group and 51 (15.6%) in control group after treatment of 14 days,and there was significant difference between two groups (χ2=11.945,P=0.001). The NIHSS scores in the observation group was lower than control group (8.3 ± 2.2vs. 9.9 ± 2.5;t=4.192,P<0.05). The mRS score in the observation group was lower than control group (2.3 ± 0.9vs. 2.9 ± 1.1;t=3.684,P<0.01), and the Barthel index in the observation group was higher than the control group (88.7 ± 16.2vs. 77.5 ± 15.2;t=4.401,P<0.01). ConclusionsThe TGP capsules combined with Urokinase intravenous thrombolysis could improve the neurological deficit, and the ability of daily life of ACIS patients.

To analyze the effect of pre-surgical status on the post-surgical stereopsis in surgically aligned adult con-comitant strabismus.By using Titmus and Randot stereo tests,we measured near stereo acuity of 99 adults who had constant exotropia and were successfully aligned by surgery.A covariance analysis showed that the post-surgical stereo acuity was significantly determined by the type of strabismus (i.e.,whether that's intermittent or not;P =0.001),the duration of pre-surgical exotropia (P =0.002)and the year on-set (P =0.048)but not by the pre-surgical deviation (P =0.133).We conclude that the stereopsis of adult concomitant strabismus can be reestab-lished by surgery,while the extent of such an improvement is determined by the type of strabismus,the duration of pre-surgical exotropia and the year on-set of patients.

Objective: To explore the clinical efficacy and mechanism of auricular point sticking plus Western medicine for moderate gastric cancer pain. Methods: A total of 80 patients were selected and divided into an observation group and a control group according to the random number table method, with 40 cases in each group. Patients in the control group received Western medicine treatment, while patients in the observation group received additional auricular point sticking. Both groups were treated for 2 weeks. Numeric rating scale (NRS) and Karnofsky performance status (KPS) were adopted before and after treatment. The total time and times of flare-up pain in 24 h were recorded. The cyclooxygenase-2 (COX-2) and tumor necrosis factor-α (TNF-α) levels were detected. The clinical efficacy of both groups was evaluated after treatment. Results: The total effective rate of the observation group was significantly higher than that of the control group (P<0.05); after treatment, NRS scores of both groups were significantly lower than those before treatment (both P<0.05), and the score of the observation group was lower than that of the control group (P<0.05); KPS scores of both groups were significantly higher than those before treatment (both P<0.05), and the score of the observation group was higher than that of the control group (P<0.05). After treatment, the total time and flare-up times of pain during 24 h of both groups were significantly reduced (all P<0.05), and those of the observation group were significantly less than those of the control group (both P<0.05). After treatment, the COX-2 and TNF-α levels of both groups were significantly reduced (all P<0.05), and were lower in the observation group than in the control group (all P<0.05). Conclusion: The clinical efficacy of auricular point sticking plus Western medicine for moderate gastric cancer pain is valid. This combined treatment can alleviate cancer pain and improve patients' quality of life, which may be related to its ability to reduce COX-2 and TNF-α levels.

Objective:To study the morphological characteristics of temporo-mandibular joint with high angle vertical skeletal pattern in adult females with class II skeletal type.Methods:41 CBCT films of adult females (20 normal controls;21 skeletal class II high angle subjects)were collected.The position of and form of condyle,form of fossa and joint spaces were measured by Mimics 17.0 soft-ware.Results:Compared with the control group the condyles in high angle patients located more posterior.The joint fossae were lower. The angles of posterior joint node bevels were smaller.The condyles were shorter,thinner and tipped more anteriorly.The position of the conyles were more anteriorly.Conclusion:Class II skeletal type adult females with high vertical skeletal patterns have different forms of fossae,different positions and forms of condyle compared with the normal controls.

Objective To explore the MRI features in mediopatellar plica and cartilage injury.Methods The MRI appearances of 30 patients with mediopatellar plica were divided into four types and chondral injury were divided into five grades,then the characteristics of MRI imaging were analyzed,and compared with arthroscopy classification.Results The MRI manifestations of A type (n =7) of mediopatellar plica showed a cordlike elevation on the synovial wall;B type (n =13) showed shelf-like appearance but did not cover the anterior surface of the medial femoral condyle;C type (n =8) showed shelf-like appearance and covered the anterior surface of the medial femoral condyle and D type (n =2) showed a central defect in the mediopatellar plica.The MRI manifestations of chondral injury grades included zero grade (n =10),Ⅰ grade (n =2),Ⅱ grade (n =7),Ⅲ grade (n =7) and Ⅳ grade (n=4).There was no statistical significance in terms of classification of mediopatellar plica and grading of cartilage injury via MRI and arthroscopy.Conclusion MRI provides solid evidence for preoperative assessment and choice of operation scheme for classification of mediopatellar plica and grading of cartilage injury in knee.

Objective To explore the MRI findings of enthesitis in peripheral ankylosing spondylitis (AS). Methods We retrospectively reviewed the MRI obtained from 13 patients with clinically-diagnosed peripheral AS. MRI finding attributable to enthesitis could be visualized as tendon or ligament enthesitis, bone marrow edema (BME), synovitis, bursitis, tenosynovitis. Results MRI findings of knee showed enthesitis in 8 knees, mainly involved in the insertions of the quadriceps tendon at the upper patellar pole , the patellar ligament at the lower patellar pole and the tibial tubercle, BME in 8 knees, synovitis in 5 knees, bursitis in 3 knees, and tenosynovitis in 4 knees. MRI findings of ankle showed enthesitis in 3 ankles, involved in plantar insertion into calcaneus and Achilles tendon insertion into the calcaneus, BME in 1 ankle, and tenosynovitis in 3 ankles. Conclusion The lower extremities are more often involved in peripheral AS than the upper extremities. MRI characteristic of enthesitis may contribute to the diagnosis of peripheral AS early combined with HLA-B27.

Objective To explore the liver pathology from live related liver transplatation(LRLT) of Wilson′s disease(WD) in children,and evaluatethe indication of LRLT.Methods The sample of this study,including the donater and patient,came from the LRLT. It was observed with HE,MASSON,Timm′s and Rubeanic staining.Results With HE and MASSON stainning,hepatocyte showed degeneration,fiber hyperplasic and false lobule formed;Timm′s and Rubeanic stainning showed typical black deposit of granules and conglomerations.Liver pathology revealed that liver cirrhosis appeared,and it was diffrentent from Child Pugh.Conclusions It is of great significance that the liver pathology is useful for the treatment of WD.If liver pathology supportes,the indication of LRLT can be measurably broadened.

Objective To evaluate the MRI and clinic types of oxfordshire community stroke project(OCSP)in the diagnosis of acute young ischemic stroke patients.Methods 1 64 young patients (18-45 years)and 228 old patients (>60 years)with acute ischemic stroke were analyzed retrospectively.There are four groups according to MR and clinic types of OCSP:total anterior circulation infarct (TACI),partial anterior circulation infarction (PACI),posterior circulation infarction(POCI)and lacunar infarction (LACI).Results Cerebral infarction showed a mild hypo-signal on T1 WI,hyper-signal on T2 WI,FLAIR and DWI.Among the 164 young patients,8 (4.88%)were classified as TACI,72 (43.90%)as PACI,30 (18.29%)as POCI and 54 (32.93%)as LACI.Young and old group image types comparison,χ2 = 1.221,P >0.05.Young stroke patients image and clinical types comparison,Kappa =0.525,P <0.05.Conclusion OCSP imaging types has a good consistency with clinical types,which helps to evaluate ischemic stroke objectively in youth.

Zinc-fingers and homeoboxes 2 (ZHX2) is a novel transcriptional repression factor participating in regulating the expression of alpha fetal protein (AFP). ZHX2 has been confirmed to be largely correlated with development and metastasis of hepatocellular carcinoma (HCC) and invasion of multiple myeloma.

Objective To study the NF-?B activity in colon carcinoma HT-29 and Lovo cells treated with different crude extracts of Abrotani herba obtained by column chromatography with macroporous resin.Methods The decoction of Abrotani herba absorbed by macroporous resin AB-8 was mounted into the column and then eluted with distilled water and 30%,50%,75% and 95% alcohol.To select appropriate concentrations for treatment,HT-29 cells were pretreated for 24 hours with each elution phase of the rude extracts in different concentrations(0,50,100,200,400 and 600?g/ml),and then their activity was detected by MTT.The HT-29 and Lovo cells were thereafter cultured in DMEM complete media respectively containing distilled water extract and 30%,50%,75% and 95% alcohol extracts in the concentrations as obtained by MTT assay,and the cells in control group were cultured in DMEM only.The cells were then harvested and the nucleic proteins were extracted for measurement with electrophoretic mobility shift assay(EMSA).Changes in NF-?B activity in HT-29 and Lovo cells treated with different concentrations of crude extracts were observed by EMSA.Results Viability of HT-29 cells treated with 400 and 600?g/ml crude extracts were significantly lower than those treated with 0-200?g/ml crude extracts(P0.05).Conclusion Crude extracts of Abrotani herba,extracted by column chromatography with macroporous resin and eluted with 30% alcohol,can inhibit NF-?B activity in colon carcinoma HT-29 and Lovo cells.