Objective A pronunciation aid device had been made by using dental prosthodontic method for the treatment of pronunciation disorder, which is caused by movement dysfunction because of defect of soft palate tissues in cleft lip and palate patients.Methods According to the defect condition in the mouth, two types of pronunciation aid devices had been produced regularly by using maxillary impression, plaster casting and thermoplastic resin materials and so on. Results In the first group of cases, after 3 patients were wearing soft palate movement pronunciation aid device, and then they were given pronunciation training, it is found that their language clearances degrees had been promoted obviously. In the second group of cases, 2 patients were wearing naso-pharynx cavity closing pronunciation aid device, it is found that their nasal sound and nasal leakage were disappeared. And in the same time we gave patients pronunciation training, and after one year, their language clearances degrees were found to be more obviously increased than before.Conclusions Naso-pharynx cavity closing pronunciation aid device and soft palate movement pronunciation aid device are an effective non-surgical treatment methods for the treatment of naso-pharynx cavity closing dysfunction and soft palate movement dysfunction.

Objective To observe the different efficacy of combination of inhaled ipratropium bromide and salbutamol and inhaling the two drugs separately. Methods Sixty -five patients with COPD were divided into 3 groups,and treated with different drugs. We observed the lung function FEV1 , the improvement of symptoms and side - effects. Results The FEV_1 and improvement of symptoms in combination group were significantly better than those in seperatin group (P

China ; Female ; Humans ; Neonatology ; ethics ; trends

Objective:To study the the correlation between the diameter or angle of thoracic-lumber pedicle and vertebral number.Method:X-ray and CT scan were performed on 46 male spine specimens.The length of pediele screw path,the cress-section angle(e) and the sagittal angle(f) of the pedicle,the width of the inner diameter of the pediele and the distance between the two pedicles were measured.The ordinal number of T1-L5 vertebral segment was numbered by 1-17.SPSS 11.5 software was used for statistical analysis.Result:The data showed a positive linear correlation with the vertebral numbers including length of T1-L4 pedicle screw path (R2=0.716),T8-L5 pedicle width (R2=0.673),T4-L5 pedicle distances (R2=0.771),T1-T2 f-angle (R2=0.767) ,T2-T4 f-angle (R2=0.908),T12-L5 pediele e-angle (R2=0.710).The negative linear correlation with thevertebral numbers included T2-T3 pedicle width(R2=0.792),T1-T4 pedicle distances(R2=0.866),T7-L5 f-an-gle(R2=0.931),T1-T6 pedicle e-angle (R2=0.774).However,the T1-T2 and T4-T7 pediele width,the T4-T6 pediele f-angle,as well as the T6-T12 pedicle e-angle had no significant correlation with the vertebral num-bers.Conclusion:Apart from the T1-T2 and T4-T7 pedicle width,the T4-T6 pedicle f-angle and the T6-T12 pedicle e-angle,the diameter or angle of the thoracic-lumbar pedicle have correlation with the vertebral numbers with meaningful linear regression equation.

Lectin like oxidized low density lipoprotein receptor 1(LOX 1) is a type Ⅱ membrane protein belonging to the C type lectin family molecules which can act as a cell surface endocytosis receptor for oxidized LDL.LOX 1 can support binding, internalization and proteolytic degradation of oxidized LDL. And LOX 1 is involved in the platelet endothelium interaction and mediates phagocytosis of aged/apoptotic cells in endothelial cells ox LDL. Purification of soluble LOX 1 and the N terminal amino acid sequencing identified the two cleavage sites (Arg 86 Ser 87 and Lys 89 Ser 90 ). LOX 1 expression is not constitutive, but can be induced by proinflammatory stimuli, such as Angiotension Ⅱ, fluid shear stress and so on.

This paper analyzes social background and ethical problems of disposing and using unreasonably High-tech equipment, and puts forward relative proposals of contermeasure.

Objectives To observe anatomical location of the top branch of plantaris arch which extends from the superficial branch of the medial plantar artery,design and apply flap base on it. Methods On the basis of the anatomical data from 8 feet of 4 fresh cadavers and probed of the Doppler from 50 feet of normal person,defined the anatomic location and body surface projection of the top branch of plantaris arch,a type of new flap design were introduced in the paper. Results The flaps have been used in six cases clinically to treat skin defect of the hand meanwhile,sensation of the flap was regained by suturing nerve.All flaps survived,the appearance of the flaps were excellent,the function of the injured hands were recovered well. Conclusions The design of the flap is reasonable,it is suitable that the free medialis pedis flap of the top branch of plantaris arch is used to repair a small skin defect of the hand.

Objective: Analysis of adult attachment in a very stressful situation, i.e., surgery. Methods: Two widely used adult attachment measurements --Relationship Questionnaire(RQ) and Experiences in Close Relationship Inventory(ECR)-are administered to 50 surgery patients in a hospital. Their personal information is also collected. Results: The distribution of 50 patients' adult attachment is: 18(36%) of them are secure, 20(40%) Dismissing, 6(12%) Preoccupied, 6(12%) Fearful. Moreover, attachment anxiety measured by ECR has negative correlation with model-of-self measured by RQ (P

Phosphodiesterases(PDEs) is the only protein enzyme family,which catalyze the hydrolysis of cyclic nucleotide second messages(cAMP and cGMP).PDEs regulate many physiologic and pathologic processes.Recent advance showed that PDE7 hydrolyze cAMP exclusively and is divided into PDE7A and PDE7B. PDE7 mainly express in immune and inflammatory cells.The selective inhibition of this family generates profound,functional effects and PDE7 has been used as a therapeutic target for diseases related with inflammation,such as chronic obstructive pulmonary disease(COPD),rheumatoid arthritis and Alzheimers disease(AD).

Objective Using hypothyroid,hyperthyroid and normol control rats model,we investigated mRNA expression of the nerve-growth-factor and its receptor TrkA in hippocampus and parietal cortex at 14,21,28days of ages,to offer a possible neurobiological explanation about mechanism of thyroid hormone modulating NGF and its receptor TrkA.Methods For hypothyroid group,rats were reared with 0.02% methimazol water from 5~6 day of gestation to the day when they were sacrificed;for hyperthyroid group,rats were daily intraperitoneal injected of 0.4?g/g body weight tiiodothyronin from beginning of delivery;for normal control rats were reared a normol diet and water.NGF mRNA and TrkAmRNA were measured by in site hybridization.Results The peak of mRNA expression of NGF and TrkA is at P21and P28 respectively,.The mRNA expression of NGF and TrkA in hypothyroid rats was significantly lower than that in age-matched euthyroid at P14,P21,P28(P