Objective A pronunciation aid device had been made by using dental prosthodontic method for the treatment of pronunciation disorder, which is caused by movement dysfunction because of defect of soft palate tissues in cleft lip and palate patients.Methods According to the defect condition in the mouth, two types of pronunciation aid devices had been produced regularly by using maxillary impression, plaster casting and thermoplastic resin materials and so on. Results In the first group of cases, after 3 patients were wearing soft palate movement pronunciation aid device, and then they were given pronunciation training, it is found that their language clearances degrees had been promoted obviously. In the second group of cases, 2 patients were wearing naso-pharynx cavity closing pronunciation aid device, it is found that their nasal sound and nasal leakage were disappeared. And in the same time we gave patients pronunciation training, and after one year, their language clearances degrees were found to be more obviously increased than before.Conclusions Naso-pharynx cavity closing pronunciation aid device and soft palate movement pronunciation aid device are an effective non-surgical treatment methods for the treatment of naso-pharynx cavity closing dysfunction and soft palate movement dysfunction.

Objective To observe the different efficacy of combination of inhaled ipratropium bromide and salbutamol and inhaling the two drugs separately. Methods Sixty -five patients with COPD were divided into 3 groups,and treated with different drugs. We observed the lung function FEV1 , the improvement of symptoms and side - effects. Results The FEV_1 and improvement of symptoms in combination group were significantly better than those in seperatin group (P

China ; Female ; Humans ; Neonatology ; ethics ; trends

That provincial hospital hosting the local hospital is an important measure to deepening the reform of medical and health system.Advanced hospital management mechanism and excellent technical experts were gradually introduced into the local hospital to establish South Hubei healthcare alliance,and form province-city-county healthcare alliance.In this way,high quality management,manpower and technology resource sink,overall medical technology level achieves good breakthrough.This promotes the rapid development of healthcare alliance member hospitals in the region.

Objective Using hypothyroid,hyperthyroid and normol control rats model,we investigated mRNA expression of the nerve-growth-factor and its receptor TrkA in hippocampus and parietal cortex at 14,21,28days of ages,to offer a possible neurobiological explanation about mechanism of thyroid hormone modulating NGF and its receptor TrkA.Methods For hypothyroid group,rats were reared with 0.02% methimazol water from 5~6 day of gestation to the day when they were sacrificed;for hyperthyroid group,rats were daily intraperitoneal injected of 0.4?g/g body weight tiiodothyronin from beginning of delivery;for normal control rats were reared a normol diet and water.NGF mRNA and TrkAmRNA were measured by in site hybridization.Results The peak of mRNA expression of NGF and TrkA is at P21and P28 respectively,.The mRNA expression of NGF and TrkA in hypothyroid rats was significantly lower than that in age-matched euthyroid at P14,P21,P28(P

Phosphodiesterases(PDEs) is the only protein enzyme family,which catalyze the hydrolysis of cyclic nucleotide second messages(cAMP and cGMP).PDEs regulate many physiologic and pathologic processes.Recent advance showed that PDE7 hydrolyze cAMP exclusively and is divided into PDE7A and PDE7B. PDE7 mainly express in immune and inflammatory cells.The selective inhibition of this family generates profound,functional effects and PDE7 has been used as a therapeutic target for diseases related with inflammation,such as chronic obstructive pulmonary disease(COPD),rheumatoid arthritis and Alzheimers disease(AD).

AIM The aim of our study was to establish drug screening models which can evaluate samples' effects on cytokines related with inflammtion, capable of fast and efficient screening of anti-inflammatory lead compounds on the release of inflammtory cytokines. METHODS Heparinized human blood leukocytes was evaluated as a model to study the effects of various classes of anti-inflammatory lead compounds on cytokine release/biosynthesis from leukocytes. Human blood leukocytes was stimulated with LPS (final concentration 0.5～50 mg?L -1), with or without test drugs (diclofenac, a cytooxygenase inhibitor, nordihydroguaiaretic acid NDGA, a 5-lipoxygenase inhibitor) for 1～4 h to induce cytokine release. RESULTS Human blood leukocytes stimulated with LPS could product IL-1, IL-8 and TNF-? in a dose-dependent manner. Human blood leukocytes was stimulated with LPS(5 mg?L -1) for 4h to induce cytokine release. TNF-?, IL-1 and IL-8 time-course profiles were determined in culture media, using bioassays and ELISA. LPS-mediated release of IL-1 and TNF-? was significantly suppressed by NDGA and Diclofenac. In LPS stimulated blood, NDGA and Diclofenac inhibited the release of TNF-?(IC 50 of 149 ?mol?L -1 and 23.88 ?mol?L -1) or IL-1 (IC 50 of 222.57 ?mol?L -1 and 126 ?mol?L -1). CONCLUSION This human blood leukocytes screening system in vitro has the potential to screen new cytokine release inhibitors and sites of action of new anti-inflammatory lead compounds, and increases the screening efficiency.

Attention deficit hyperactivity disorder(ADHD) is one of the most common psychiatric disorders among school-age children.The diagnosis and treatment of ADHD rely on a comprehensive evaluation of symptom,functional impairment and comorbidity.Therefore the standardized rating scales is widely used clinically.The standardized rating scales can be categorized into: Broad-band scales,evaluating the general misbehavior and sociopsychological functions andNarrow-band scales,evaluating ADHD specific symptoms,and also functional impairment rating scales.Useful comorbidity and functional impairment rating scales are in need domestically.This paper reviewed the published literature about the clinical application and progression of frequently-used rating scales for school-age ADHD evaluation,at home and abroad.

Objective] To observe the prevention and treatment of incision fat liquefaction after caesarean section with external mirabilite application. [Method] The cases were collected from Jan. 2010 to Jan. 2013, in accordance with standard cases. Select 200 cases of puerpera with bad high risk factors of incision cure, randomly divide them into control group(routine changing prescription without mirabilite) 100 cases and prevention group(routine changing prescription added with mirabilite external application) 100 cases, observe both groups cut cure after 7d.[Result] In mirabilite prevention group, 98 cases were cured well, 1 case was not very good, 1 bad; in control group, 88 were excellent, 4 not very good and 8 bad, the cure excellent rate of prevention group was much better than control group(P<0.05), as well as the incision fat liquefaction rate much lower than control one. [Conclusion] Mirabilite external application can promote incision cure after caesarean section and reduce incision fat liquefaction.

Objective To evaluate the effect of locking compression plate for treatment in the osteoporotic of unstable distal radius fractures.Methods 48 cases of osteoporotic of unstable distal radius fractures were treated with open reduction and LCP fixation through volar approach.They were 8 men and 40 women aged from 58 to 77 years (range,63.7 years).They were all diagnosed by dual energy X ray absorptiometry before operation.According to AO/OTA criterion,there were 12 patients with type B2 fractures,10 cases with type B3,8 cases with type C1,13 cases with type C2,5 cases with type C3.All patients were performed locking plate fixations through volar approach and no bone graf.All patients were assessed from time of fracture healing,palmar tilt,radiographic measurements of ulnar inclination,radial height,and range of motion after 18 months,to evaluate the effect of clinical results and postopera-tive functional recovery.Results The patients were followed up for average 17.8 months (range,12 -24 months). All fratures united within 6 months (3 to 7 months),no infection in all patients,reduction loss in 2 cases after operation,traumatic arthritis in three.According to the Cooney criterion,the result was excellent in 35 pateints,good in 9 cases,fair in 3 cases and poor in 1 case,and the excellence rate was 92%.Conclusion The valor approach with locking compression plate can provide firm fixation and allow early functional exercise and so is suitable for unstable distal radius fracture especially in the osteoporotic of unstable distal radius fractures.