Professionalism is the core quality necessary for outstanding physicians in the new era. As an important content of medical students’ ideological and political education， the medical professionalism with the scientific connotation of “respecting and protecting life， healing the wounded and rescuing the dying， being willing to contribute， and boundless love” radiates new vitality in the new era. The medical professionalism in the new era embodies the unity of science and humanity， regularity and purposefulness， timeliness and development， and theoreticality and practicality. In the ideological and political education of medical students based on the cultivation of professionalism in the new era， only by insisting on the combination of “ideological and political education in the curriculum” and “ideological and political courses”， “supply” and “demand”， “on-campus” and “off-campus”， and “virtual” and “reality”， as well as strengthening internal cohesion and external connection and making targeted efforts， the medical professionalism can better be cultivated， providing spiritual support for training a new force for the construction of a healthy China.

The unexpected COVID-19 brings a great challenge to the cultivation of medical students’ professional spirit. However, the traditional cultivation mode of professional spirit is single, which could not meet the urgent needs for cultivating high-quality medical talents. Therefore, under the background of epidemic prevention and control, the optimization of the cultivation path of medical students’ professional spirit should be carried out in the medical colleges and universities to adapt the development requirements of the era. Firstly, taking reshaping the top-level design of the school as the starting point, providing institutional guarantee, improving the curriculum and optimizing the teaching staff. Secondly, focusing on improving teaching process, optimizing teaching design, innovating teaching forms and establishing model education. Lastly, taking realize the unity of knowledge, emotion and intention of medical students as the foothold, strengthening the study of theoretical knowledge, participating in the construction of campus culture and social practice activities. The trinity cultivation model of "school-teachers-students" will be constructed to collaboratively promote the benign development of medical students’ professional spirit cultivation.