Cardiac toxicity of anthracycline greatly limit its clinical use,to explore the rule of anthracycline cardiotoxicity and prevention and control strategies of Chinese and western medicine,this paper through the literature search mechanism and drugs is summarized,the mechanism can be divided into oxidative stress,inflammatory reaction,myocardial cell autophagy and DNA damage four categories,the prevention and treatment of western medicine to dc prosamine,ACEI,ARB is given priority to,Chinese medicine can be divided into single medicine,by prescription and proprietary Chinese medicine.On this basis,the combination drug is discussed to prevent cardiotoxicity,and the theoretical basis and research status of the combined application of western medicine,traditional Chinese medicine and Chinese and western medicine are introduced.The results show that it has good feasibility and safety,and can provide reference for the clinical treatment strategy of anthracycline chemotherapy drugs.

OBJECTIVETo investigate the effects of labrasol, solutol HS 15 and transcutol P on the corneal permeability of mangiferin in vitro.

METHODThe effects of three penetration enhancers on the corneal permeability of mangiferin were investigated in vitro by using isolated rabbit corneas.

RESULTThe apparent Papp enhancements were increased 1.80, 3.27, 3.41 and 4.76-folds with Lab at 1.0%, 1.5%, 2.0% and 3.0% (P < 0.01), respectively. The apparent Papp increased 1.98 and 3.07-folds with Sol at 0.2% and 0.4% (P < 0.01), respectively, but reduced with 0.010%-0.03% Trans.

CONCLUSIONThe Papp value of mangiferin is significantly enhanced by 1.0%-3.0% Lab, 0.2% and 0.4% Sol, however the Papp value of mangiferin is reduced by 0.01%-0.03% Trans.

Animals ; Cornea ; drug effects ; metabolism ; Drug Carriers ; chemistry ; Ethylene Glycols ; chemistry ; Glycerides ; In Vitro Techniques ; Organic Chemicals ; chemistry ; Permeability ; Plant Extracts ; pharmacokinetics ; Polyethylene Glycols ; chemistry ; Rabbits ; Stearic Acids ; chemistry ; Xanthones ; pharmacokinetics