BACKGROUND: Tuberculosis has commonly been associated with various hematologic changes. A difference between the changes found in pulmonary tuberculosis and those found in miliary tuberculosis has been discussed. Up to now some worker were investigated hematological changes associated with pulmonary tuberculosis but was not investigated those associated with miliary tuberculosis in korea. Therefore we examimed the peripheral blood and bone marrow findings in miliary tuberculosis patients to determine hematologic changes. METHODS: We performed blood sample at admission and bone marrow biopsy within 7days after admission. For evaluation of the hematologic findings, full blood counts and marrow differential counts were defined by the criteria outlined by Dacie and Lewis2). RESULTS: 1) Peripheral blood findings: Pancytopenia in 10% of patients, anemia in all patients, leukocytosis in 10% of patients, leukopenia in 20% of patients, thrombocytopenia in 30% of patients, lymphocytopenia in 90% of patients, monocytosis in 40% of patients and neutrophilia in 10% of patients were found at peripheral blood. 2) Bone marrow findings: Lymphocytopenia in 30% of patients, lymphocytosis in 20% of patients, plasmacytosis in 40% of patients, monocytosis in 100% of patients, and hypocellularity in 30% of patients were found at bone marrow. Erythropoiesis was decreased in 30% of patients. Granulopoiesis was decreased in 20% of patients and increased in 20% of patients. Bone morrow granuloma occured in 25% of patients. CONCLUSION: Hematologic changes of miliary tuberculosis were seen tendency of cytopenic pattern but monocyte was increased at peripheral blood and bone morrow. This findings would provide additional information for the differential diagnosis of miliary tuberculosis.
Anemia ; Biopsy ; Bone Marrow* ; Diagnosis, Differential ; Erythropoiesis ; Granuloma ; Hematology ; Humans ; Korea ; Leukocytosis ; Leukopenia ; Lymphocytosis ; Lymphopenia ; Monocytes ; Pancytopenia ; Thrombocytopenia ; Tuberculosis ; Tuberculosis, Miliary* ; Tuberculosis, Pulmonary

No abstract available.
Pelger-Huet Anomaly*

Acute eosinophilic pneumonia (AEP) represents a clinical entity distinct from chronic eosinophilic pneumonia (CEP). In contrast with CEP, AEP is characterized by duration of symptoms less than 5 days, hypoxemic respiratory failure, no blood eosinophilia at presentation, no atopic background or history of asthma, and no recurrence. However, we report a case of AEP with some features of CEP. A 33-year-old man presented with respiratory symptoms for 4 days. He was diagnosed with AEP based on hypoxemic respiratory failure, diffuse alveolar-interstitial chest X-ray infiltrates, and eosinophilia, lymphocytosis and neutrophilia from bronchoalveolar lavages. However, he had two atopic diseases, asthma and atopic dermatitis. In addition, he presented with blood eosinophilia, which are all features of CEP. Thus, there might be some overlap of clinical features between AEP and CEP. The presence of increased lymphocytes and neutrophils in the bronchoalveolar lavage can be an important finding to help distinguish between AEP versus CEP in difficult cases.
Adult ; Asthma ; Bronchoalveolar Lavage ; Dermatitis, Atopic ; Eosinophilia ; Eosinophils ; Humans ; Lymphocytes ; Lymphocytosis ; Neutrophils ; Pulmonary Eosinophilia ; Recurrence ; Respiratory Insufficiency ; Thorax

There have been some 50 reports on the blood pictures of leprosy patients, but all of them have been dealt with the peripheral blood and more over each investigator presented the different data. In order to find cut the typical blood pictures both peripheral and bone marrow as well as the blood pictures between the various types of leprosy and the nature of anemia brought about after the use of D.D.S. derivatives, the author examined the blood of 53 cases of early leprosy patients with the following results: 1. Peripheral Blood Pictures: a. About one third of leprosy patients showel the anemic blood picture and one half of T type leprosy cases gave the anemic picture. Almost all of them were normocytic and hypochromic anemia. b. Shift to the left was found in about 50% of the cases. c. Eosinophilia was observed in the majority of the cases and all of the T type showed eosinophilia. d. There was found lymphocytosis in approximately one third of total cases and half of T type patients showed lymphocytosis. e. Lymphopenia was encountered in one fourth of them and was most frequently seen in L type patients. F. About half of all cases showed monocytopenia. g. Only 10% of patients showed the accelaration in Erythrocyte Sedimentation Rate. 2. Bone Marrow Findings: a. Myeloblastosis was noted in about 50% of them and more frequently seen in T type and I group than the other types. b. There was observed eosinophilia in almost all cases and especially its frequency was higher in T type and I group. c. Lymphocytosis was found in about one third of the total eases and its frequency was highest in L type. whereas in the peripheral blood the lymphocytosis was most frequently seen in T type. d. Plasmocytosis was noted in the majority of the patients and was found in all cases of T type and I group. 3. Seventy percent of the cases showed the increased WBC alkaline phosphatase. 4. No granulomatous changes or any other pathological changes were noted in the histological section of the bone marrow
Alkaline Phosphatase ; Anemia ; Anemia, Hypochromic ; Blood Sedimentation ; Bone Marrow ; Eosinophilia ; Humans ; Leprosy* ; Lymphocytosis ; Lymphopenia ; Research Personnel

Idiopathic hypereosinophilic syndrome is characterized by multiorgan involvement without any cause, and peripheral eosinophilia(1,500/microliter) for more than 6 months. Clinically, many organs can be involved, but the heart is the most commonly involved organ. Although lung involvement is usual(20-30%)1) in hypereosinophilic syndrome, there are few reports of eosinophilic pneumonia proven by biopsy confirmation in Korea. We experienced a case of hypereosinophilic syndrome with eosinophilic pneumonia and bronchitis confirmed by biopsy, and we report it here with a review of the literature.
Biopsy ; Bronchitis* ; Eosinophils* ; Heart ; Hypereosinophilic Syndrome* ; Korea ; Lung ; Pulmonary Eosinophilia*

We report a case of idiopathic hypereosinophilic syndrome (HES) presenting with deep vein thrombosis and subsequent massive pulmonary embolism. The eosinophilia and thromboembolism improved dramatically with systemic corticosteroid and anticoagulation therapy. However, the early and rapid tapering of corticosteroid, in a state of normal eosinophil count and therapeutic PT level, aggravated thromboembolism. An immediate retrial of corticosteroid made disease improve again. The etiology of HES and the pathogenesis of thrombus formation in HES still remain uncertain but corticosteroid in treatment of HES is yet cardinal and should be maintained for a prolonged period of time.
Eosinophilia ; Eosinophils ; Hypereosinophilic Syndrome* ; Pulmonary Embolism* ; Thromboembolism ; Thrombosis ; Venous Thrombosis*

Splenic lymphoma with villlous lymphocytes (SLVL) is a B cell chronic lymphoproliferative disorder which affects predominantly elderly males. Most patients present with splenomegaly without lymphadenopathy and a lymphocytosis. This report describes a case of SLVL in 66 year old male who complained abdominal discomfort and abdominal mass. The leukocyte count was 47.8x109/L with 89% atypical lymphocytes showing variable amout of moderately basophilic cytoplasm and unevenly distributed or polar cytoplasmic villi. The bone marrow was effaced with these neoplastic lymphocytes. The immunophenotype of the neoplastic B cells was CD19 (+), CD20 (+), CD22 (+), CD11c (+), CD2 (-), CD3 (-), CD5 (-), CD10 (-), CD25 (-) and CD15 (-). The cytogenetic findings exhibited 46,XY,del (3) (q24),del (10) (p12). The spleen was weighted 520g and had nodular infiltrates of neoplastic B cells in the region of the white pulp with minimal red pulp involvement.
Aged ; B-Lymphocytes ; Basophils ; Bone Marrow ; Cytogenetics ; Cytoplasm ; Humans ; Leukocyte Count ; Lymphatic Diseases ; Lymphocytes* ; Lymphocytosis ; Lymphoma* ; Lymphoproliferative Disorders ; Male ; Spleen ; Splenomegaly

Angiolymphoid hyperplasia with eosinophilia (ALHE) and Kimura's disease were classified as same disease in the past. Since there are many different clinical and histopathological characteristics that warranted their distinction, they are classified as different disease now. Six cases of Kimura's disease in upper extremity have been reported in Korean literature but ALHE in upper extremity has not been reported yet. We experienced a case of surgically treated ALHE in the upper arm and report this case with review of literature.
Angiolymphoid Hyperplasia with Eosinophilia ; Arm ; Eosinophilia ; Upper Extremity

Clozapine, one of the dibenzodiazepine derivatives, has potent antipsychotic properties and acts on schizophrenic patients who are nonresponsive to classic neuroleptics without neurologic side effects such as extrapyamidal symptoms, tardive dyskinesia and neuroleptic malignant syndrome. But, several blood dyscrasias associated with clozapine are well known to clinicians. Potentially life-threatening agranulocytosis, leukopenia and leukocytosis are most widely reported. Also eosinophilia has been identified as a potential side effect in some studies or case reports. We report a case of severe eosinophilia associated with the administration of clozapine in a male schizophrenic patient, which improved spontaneously along with clozapine maintenance therapy. We also reviewed previous reports of eosinophilia induced by clozapine adminstration and recognized that eosinophilia is not uncommon and transient side effect of clozapine.
Agranulocytosis ; Antipsychotic Agents ; Clozapine* ; Eosinophilia* ; Humans ; Leukocytosis ; Leukopenia ; Male ; Movement Disorders ; Neuroleptic Malignant Syndrome ; Schizophrenia

No abstract available.
Eosinophils ; Pulmonary Eosinophilia