Leukemoid reactions often are seen in patients with underlying malignancies, but they have been reported infrequently in patients with urologic malignancies. We report leukemoid reaction in a patient with renal cell carcinoma. The hematological abnormality had not resolved with definite surgical and hormonal therapies for the underlying renal cell carcinoma.
Carcinoma, Renal Cell* ; Humans ; Leukemoid Reaction*

A leukemoid reaction is usually associated with malignancies of the lung, stomach, and thyroid. In contrast, urothelial cell carcinoma is rarely associated with leukemoid reactions, with few cases reported over the past 30 years. Here, we describe a patient with urothelial cell carcinoma who exhibited a leukemoid reaction. The patient had an elevated white blood cell count and experienced a rapid and aggressive clinical course, terminating in death. For urothelial cell carcinoma patients exhibiting a leukemoid reaction, removal of the inciting tumor is the definitive treatment. However, considering the aggressive nature of these tumors, if the patient is unsuitable for radical surgical management, palliative chemotherapy should be considered.
Drug Therapy ; Humans ; Leukemoid Reaction* ; Leukocyte Count ; Lung ; Paraneoplastic Syndromes* ; Prognosis* ; Stomach ; Thyroid Gland

Pseudomembranous colitis (PMC) is highly prevalent in patients with broad spectrum antibiotic therapy. It can result in significant morbidity and mortality, especially if it is not diagnosed early. The clinical manifestation of PMC is diverse and symptoms usually are increased order of severity. Although leukocytosis is common, leukemoid reaction is very rare in PMC. We report a case of PMC associated with a leukemoid reaction without typical symptoms in a type 2 diabetic patient who have the multiple diabetic complications.
Clostridium difficile ; Diabetes Complications ; Diabetes Mellitus ; Enterocolitis, Pseudomembranous* ; Humans ; Leukemoid Reaction* ; Leukocytosis ; Mortality

The solid and hematologic cancer are occasionally accompanied by peripheral blood eosinophilia and suggest tumor necrosis or wide dissemination, but the mechanisms underlying this curious relationship remain obscure. The association of this eosinophilic leukemoid reaction with carcinoma seems to occur must frequently with bronchogenic carcinoma. Several mechanisms for this association were considered: eosinophil chemotactic factor, eosinophil mediated by T-lymphocyte, and eosinopoietic hormone. We are here reporting a case of bronchoalveolar cell carcinoma of lung associated with peripheral eosinophilia in a 60-year-old male patient.
Carcinoma, Bronchogenic ; Eosinophilia* ; Eosinophils ; Humans ; Leukemoid Reaction ; Lung* ; Male ; Middle Aged ; Necrosis ; T-Lymphocytes

Blood Cells ; immunology ; pathology ; Bone Marrow Cells ; immunology ; pathology ; Child, Preschool ; Diagnosis, Differential ; Female ; Humans ; Immunophenotyping ; Leukemoid Reaction ; diagnosis

Renal cell carcinoma has been recognized for several years as a relatively common cause of paraneoplastic syndromes. Fever, polycythemia, hypercalcemia, amyloidosis, abnormal liver function, Cushing's syndrome and neuropathy have been ostm frequently reported in association with renal cell carcinoma, but leukemoid reactions have been reported only rarely with this tumor. Recently we experienced a leukemoid reaction in a 64-year old female patient who presented with an advanced case of renal cell carcinoma. According to the literature the mortality is 100% with leukemoid reactions in renal cell carcinoma, and indeed this patient expired. We therefore, consider this reaction as a late manifestation of a bizzare presentation of renal cell carcinoma.
Amyloidosis ; Carcinoma, Renal Cell* ; Cushing Syndrome ; Female ; Fever ; Humans ; Hypercalcemia ; Leukemoid Reaction* ; Liver ; Middle Aged ; Mortality ; Paraneoplastic Syndromes ; Polycythemia

A leukemoid reaction is defined as reactive leukocytosis exceeding 50,000/mm3, with a significant increase in early neutrophil precursors, and can be a paraneoplastic manifestation of various malignant tumors. A 71-year-old male patient complained of decreased appetite, fatigue, and abdominal fullness. He had a palpable, firm liver, and laboratory investigations suggested leukemoid reaction. Liver dynamic computed tomography revealed a hypervascular mass, and an ultrasound-guided fine-needle aspiration of the mass confirmed hepatocellular carcinoma (HCC) with a sarcomatoid component. The leukocyte count of the patient had increased to 147,800/mm3, and he died 10 days after admission. This is a rare case of leukemoid reaction in a patient with sarcomatous HCC.
Aged ; Biopsy, Fine-Needle ; Carcinoma, Hepatocellular/*pathology ; Humans ; Leukemoid Reaction/*diagnosis ; Leukocyte Count ; Liver Neoplasms/*pathology ; Male ; Tomography, X-Ray Computed

Chronic neutrophilic leukemia is a rare myeloproliferative disorder. We have experienced a typical case of chronic neutrophilic leukemia in a 76-year-old man who complained abdominal distension due to hepatosplenomegaly. White blood cell count of peripheral blood was 50,500/nL with 90% segmented neutrophils. The underlying disease for a leukemoid reaction had not been detected. Leukocyte alkaline phosphatase score and the serum levels of vitamin B12 and uric acid were elevated. Chromosome study showed a normal karyotype without Philadelphia chromosome or bcr/abl rearrangement. Phorbol myristate acetate-activated respiratory burst activity of neutrophils measured with chemiluminescence showed increased activity.
Aged ; Alkaline Phosphatase ; Humans ; Karyotype ; Leukemia, Neutrophilic, Chronic* ; Leukemoid Reaction ; Leukocyte Count ; Leukocytes ; Luminescence ; Myeloproliferative Disorders ; Myristic Acid ; Neutrophils* ; Philadelphia Chromosome ; Respiratory Burst* ; Uric Acid ; Vitamin B 12

BACKGROUND: Abnormalities of the peripheral blood are frequent and varied in patients with miliary tuberculosis. Anemia,leukopenia, thrombocytopenia, pancytopenia, monocytosis, basophilia, eosinophilia and leukemoid reactions have been reported. These abnormalities are more frequent in patients with positive bone marrow study. In this report, we evaluated clinical, hematological and immunological features in patients with miliary tuberculosis in order to know whether difference is existed between "bone marrow biopsy positive group(pathologically proven to miliary tuberculosis)" and "negative group". METHOD: Clinical evaluation, serum ADA, sIL-2R, and T-lymphocyte subsets were measured in 40 patients with miliary tuberculosis who received bone marrow biopsy. RESULTS: 1) The average age of patients was 39 year-old. There were 23 male and 17 female patients. Associated extrapulmonary tuberculosis are 9 CNS tuberculosis, 6 joint tuberculosis, and 2 tuberculous pleurisy. 2) Sixteen of the 40 patients were positive bone marrow biopsy(60%). 3) Sixteen of the 40 patients(60%) had anemia(ll positive patients: 13 negative patients). Leukopenia occurred in 12 per cent(4:l). Thrombocytopenia was noted in 10%(3:1). 4) The mean value of serum ADA was 83 U/L(90 U/L: 70.6 U/L, p=0.23). 5) The mean activity of Soluble IL-2 receptor was 4,643 pmol/L(6840+/-7446 pmol/L: 1,897 +/- 1,663 pmol/L, p=0.06). 6) In the T lymphocyte subsets, the percent of T-lymphocytes was 64%(62%:73%, p=0.2). In some patients(9), T4 and T8 ratio in BAL fluid(1.97+/-1.2) was higher than that in the peripheral blood(1.16+/-0.5). CONCLUSION: Bone marrow examination are diagnostic in 60% of cases of miliary tuberculosis. Percents of the total T lymphocyte and helper T cell in BAL are more elevated than in peripheral blood. There was no significant difference in peripheral blood abnormalities and marker of T lymphocyte activation between the bone marrow biopsy positive and negative group.
Biopsy ; Bone Marrow Examination ; Bone Marrow* ; Eosinophilia ; Female ; Humans ; Leukemoid Reaction ; Leukopenia ; Lymphocyte Activation ; Lymphocytes ; Male ; Pancytopenia ; Receptors, Interleukin-2 ; T-Lymphocyte Subsets ; T-Lymphocytes ; Thrombocytopenia ; Tuberculosis ; Tuberculosis, Miliary* ; Tuberculosis, Osteoarticular ; Tuberculosis, Pleural

We made a clinical obserration of 84 cases of congenital syphilis at the pediatric department of Hanyang University Hospital in Seoul, Korea during the preiod from July, 1972 to June, 1978. The results were as following: 1. The incidence of congenital syphilis in the newborn infants delivered at the nursery was 0.47% among fullterm babies (28cases/6,056 born alive) and 2,31% among premature babies(8 cases/346 born alive) during the above mentioned period. 2. The incidence of congenital syphilis was 0.42% among all patients of pediatric ward(37cases/8,711) and 0.02% among all out patients of pediatric department (11cases/52,832)during the same above mentioned period. 3. Male to female sex ratio was about 2.2:1. 4. In the newborn nursery, 33.3%(20 of total 36 Pts) were under 2,500gm of birth weight and 20.5%(16 of total 36Pts) were under 37 wks of gestational periods. 5. 73%(35 of total 48Pts)of congenital syphilis in th OPD and ward of pediatric department had the onset of the first clinical feature within one month after birth. 6. The principal clinical features of congenital syphilis observed from the O.P.D. and ward of pediatric dept. were hepatosplenomegaly 62%(52 cases), skin manifestations 60.7%(51 cases), jaundice 31%(26 cases) and nasal stuffness and /or rhinitis 28.6%(24 cases) inorder. 7. In the examination of peripheral blood, anemia was shown in 70%, leukocytosis in 45% and leukemoid reactions in 10% of them. 8. Syphilitic bone changes in the bone X-ray films were detected in 35.7% of all 28 observed cases. 9. The complications or combined diseases were pneumonia (10 cases), sepsis (9 cases), tetanus (2 cases), meningitis (1 case), respiratory distress syndrome( 1 case) and congenital heart anomaly(1 case). 10. The mortality rate was 12% (10 cases/84)
Anemia ; Birth Weight ; Female ; Heart ; Humans ; Incidence ; Infant, Newborn ; Jaundice ; Korea ; Leukemoid Reaction ; Leukocytosis ; Male ; Meningitis ; Mortality ; Nurseries ; Outpatients ; Parturition ; Pneumonia ; Rhinitis ; Seoul ; Sepsis ; Sex Ratio ; Skin Manifestations ; Syphilis, Congenital* ; Tetanus ; X-Ray Film