1.A case clinic analysis of leukemoid reaction.
Jun-jun YANG ; Hui CHEN ; Yan LI
Chinese Journal of Pediatrics 2003;41(10):787-788
2.A case of leukemoid reaction in a patient with sarcomatous hepatocellular carcinoma.
Hyun Phil SHIN ; Jung Won JEON ; Jae Jun PARK ; Jae Myung CHA ; Kwang Ro JOO ; Joung Il LEE ; Gou Young KIM ; So Young KANG
The Korean Journal of Hepatology 2011;17(3):226-228
A leukemoid reaction is defined as reactive leukocytosis exceeding 50,000/mm3, with a significant increase in early neutrophil precursors, and can be a paraneoplastic manifestation of various malignant tumors. A 71-year-old male patient complained of decreased appetite, fatigue, and abdominal fullness. He had a palpable, firm liver, and laboratory investigations suggested leukemoid reaction. Liver dynamic computed tomography revealed a hypervascular mass, and an ultrasound-guided fine-needle aspiration of the mass confirmed hepatocellular carcinoma (HCC) with a sarcomatoid component. The leukocyte count of the patient had increased to 147,800/mm3, and he died 10 days after admission. This is a rare case of leukemoid reaction in a patient with sarcomatous HCC.
Aged
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Biopsy, Fine-Needle
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Carcinoma, Hepatocellular/*pathology
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Humans
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Leukemoid Reaction/*diagnosis
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Leukocyte Count
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Liver Neoplasms/*pathology
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Male
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Tomography, X-Ray Computed
3.Neutrophilic Leukemoid Reaction Associated with Malignancy Initially Suspected as Chronic Neutrophilic Leukemia.
Min Kyung SO ; Sholhui PARK ; Yeung Chul MUN ; Chu Myong SEONG ; Hee Jin HUH ; Jungwon HUH
Laboratory Medicine Online 2017;7(4):206-210
Although neutrophilia can manifest from various causes, it is important to be able to distinguish chronic neutrophilic leukemia (CNL) from neutrophilic leukemoid reactions (NLR). In this paper, we describe four cases of leukocytosis with neutrophilia, including one case of CNL with a T618I mutation in colony stimulating factor 3 receptor (CSF3R) and three cases of NLR associated with malignancy or sepsis, which were initially suspected as CNL. Of the three NLR cases, one was associated with ovarian cancer, one with monoclonal gammopathy of undetermined significance and one with multiple myeloma with sepsis. This study demonstrated that confirming the clonality of myeloid cells with CSF3R T618I could contribute to making an accurate differential diagnosis between CNL and NLR in patients with solid cancers or plasma cell neoplasms caused by paraneoplastic syndromes and/or infection.
Colony-Stimulating Factors
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Diagnosis, Differential
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Humans
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Leukemia, Neutrophilic, Chronic*
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Leukemoid Reaction*
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Leukocytosis
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Monoclonal Gammopathy of Undetermined Significance
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Multiple Myeloma
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Myeloid Cells
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Neoplasms, Plasma Cell
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Neutrophils*
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Ovarian Neoplasms
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Paraneoplastic Syndromes
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Sepsis
4.Incidentally Found Chronic Neutrophilic Leukemia in a Patient with Rectal Cancer.
Seok Hyung KIM ; Hae Yeul PARK ; Changhyeok HWANG ; Younghak JUNG ; Minjoo LEE ; Sung Eun CHOI ; Yu Ri KIM
Korean Journal of Medicine 2016;90(1):59-62
Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm characterized by sustained neutrophilia, splenomegaly, and hypercellular bone marrow without Philadelphia chromosome. Diagnosis of CNL requires exclusion of identifiable causes of reactive neutrophilia, such as infection and tumors. Our patient presented with general weakness and weight loss. Computed tomography (CT) showed a mass in the distal rectum, which was confirmed to be an adenocarcinoma by colonoscopic biopsy. Positron emission tomography-CT showed multiple liver, bone, and lymph node metastases. Liver and lymph node biopsies revealed neutrophilic infiltration with no evidence of adenocarcinoma. The pathological findings of the bone marrow were compatible with CNL. Cytogenetic analysis revealed a normal karyotype, and molecular analysis was negative for BCR/ABL. Here, we present a 73 year-old man diagnosed with concurrent CNL and rectal cancer.
Adenocarcinoma
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Biopsy
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Bone Marrow
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Cytogenetic Analysis
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Diagnosis
;
Electrons
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Humans
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Karyotype
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Leukemia
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Leukemia, Neutrophilic, Chronic*
;
Leukemoid Reaction
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Leukocytosis
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Liver
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Lymph Nodes
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Neoplasm Metastasis
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Neutrophils
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Philadelphia Chromosome
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Rectal Neoplasms*
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Rectum
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Splenomegaly
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Weight Loss