No Abstract Available.
Leukemia* ; Leukemic Infiltration* ; Skin*

Leukemic infiltration of the penis is an extremely rare entity. A case involving the penile shaft is described, and the relevant evaluation and treatment are discussed. Only 3 other documented cases of penile leukemia have been found in the literature. The identification and treatment of the underlying etiology are important aspects with this unusual disease entity.
Leukemia ; Leukemic Infiltration* ; Male ; Penis*

No abstract available.
Biopsy* ; Leukemic Infiltration* ; Renal Insufficiency*

No abstract available.
Leukemia, Monocytic, Acute* ; Leukemic Infiltration* ; Lymphatic Diseases* ; Skin*

OBJECTIVETo investigate clinical features, diagnosis, therapy, and prognosis in a case of chronic lymphocytic leukemia (CLL) with central nervous system (CNS) invasion.

METHODSThe cellular morphology of bone marrow, cytology and flow cytometry of cells in CSF, and radiographic manifestations were detected in a patient diagnosed as CLL with CNS invasion. The clinical features, pathogenesis, diagnosis,therapy, and prognosis of CLL with CNS invasion were reviewed by literatures.

RESULTSA clonal population of B lymphocytes with typical characteristics of immunophenotype was identified in the patient. After treated with intrathecal chemotherapy, the patient returned to normal cells count of cerebrospinal fluid and normal neurologic status. Previous studies also have demonstrated the efficacy of intrathecal chemotherapy.

CONCLUSIONCNS invasion is a rare complication of CLL. Early detection and treatment may result in better outcomes.

Aged ; Central Nervous System ; pathology ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell ; pathology ; Leukemic Infiltration ; Male ; Prognosis

Leukemic infiltration of the testes has been relatively rare disease. Rut increased survival due to advance in the treatment of childhood leukemia has been associated with an increased in incidence of leukemic infiltration of the testes. Eight of 42 male children with acute lymphocytic leukemia who have been admitted to our hospital during past 9 years period, from January, 1975 to December, 1983, developed testicular leukemia. This represented an incidence of 19% and the median age was 6.8 years. All patient were symptom free despite testicular enlargement. The enlargement is bilateral in 4 and unilateral in 4. Microscopic finding on specimen were leukemic infiltration mainly in the interstitial spaces and atrophy of spermatogenic cells.
Atrophy ; Child ; Humans ; Incidence ; Leukemia* ; Leukemic Infiltration ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Rare Diseases ; Testis

Cutaneous manifestations in leukemia present an important diagnostic challenge to dermatologists. The skin lesions can be classified as either specific or non specific. Lesions that are the direct result of infiltration and proliferation of leukemic cells in the skin are known as "specific lesions" or "leukemia cutis". Leukemic infiltration of the skin occurs in 3% to 11% of patients with adult leukemia. Non specific lesions(leukemids) occur in approximately 30% of patients with leukemia. Acute basophilic leukemia(ABL) is a rare disorder characterized by many mature and immature basophils in the blood, marrow, and other organs. This type of leukemia has not been included in the French-American-British(FAB) classification. The frequency of specific or non specific skin lesions associated with ABL has not been reported. We report herein a case of leukemid with various skin manifestations associated with ABL.
Adult ; Basophils ; Bone Marrow ; Classification ; Humans ; Leukemia ; Leukemia, Basophilic, Acute* ; Leukemic Infiltration ; Skin ; Skin Manifestations

OBJECTIVETo report a case of blastic natural killer cell leukemia with an aggressive clinical course.

METHODSThe characteristics of blastic NK cell leukemia and its treatment were discussed with review of literatures.

RESULTSAfter combination chemotherapy and spinal cord segmental radiotherapy, the patient entered hematological remission, but the extramedullary lesion remained unchanged.

CONCLUSIONBlastic NK cell leukemia has an aggressive clinical course with poor response to treatment and unfavorable prognosis.

Adult ; Combined Modality Therapy ; Humans ; Killer Cells, Natural ; pathology ; Leukemia, Lymphoid ; pathology ; therapy ; Leukemic Infiltration ; Male

There have been several reported cases of acute lymphoblastic leukemia with severe lactic acidosis in adults. In these cases, kidney and liver enlargement that was caused by leukemic infiltration frequently accompanied the acute lymphoblastic leukemia and severe lactic acidosis. Chemotherapy is the only treatment that can rapidly correct the lactic acidosis and normalize the liver and kidney enlargement. We report here on a case of acute lymphoblastic leukemia that was accompanied with severe lactic acidosis and kidney enlargement.
Acidosis, Lactic ; Adult ; Humans ; Kidney ; Leukemic Infiltration ; Liver ; Precursor Cell Lymphoblastic Leukemia-Lymphoma

We have experienced a rare case of leukemic lesion(chloroma) in the lower spinal canal which was confirmed by the surgery and histologic examination of the tumor. A farmer, aged 39, was admitted to the Department of Neurosurgery, St. Paul Hospital in December 1974 with chief complaints of low back pain with radiating pain in the right lower extremity and voiding difficulty for one month. On admission, neurologically, the patient exhibited weakness of the right anterior tibialis, extensor hallucis longus and peroneus longus and brevis muscles and sensory involvement of the right third, fourth and fifth sacral dermatomes. He was disclosed the positive signs of the Naffziger's and Lasegue's and severe tenderness on the spinous process of the fifth lumbar and first sacral vertebrae. Lumbar myelogram demonstrated a total block at lower level of the fifth lumbar vertebra and a filling defect of the right fifth lumbar root area. Through the laminectomy of fourth lumbar to first sacral lamina, an extradural greenish soft mass located at the ventral aspect of the right fifth lumbar to upper sacral roots, and the mass was removed. The biopsy specimen disclosed chloroma with leukemic infiltration of the meninges.
Biopsy ; Humans ; Laminectomy ; Leukemic Infiltration ; Low Back Pain ; Lower Extremity ; Meninges ; Muscles ; Neurosurgery ; Sarcoma, Myeloid ; Spinal Canal* ; Spine