Although occasional patients with chronic myeloid leukemia (CML) have chromosomal changes other than Philadelphia chromosome early in the disease, in typical cases the 9;22 translocation remains the sole abnormality throughout the disease course in chronic phase. When disease progression occurs, however, 75-80% develop additional chromosome aberrations. These secondary changes sometimes precede the more aggressive manifestations hematologically and clinically and thus may serve as valuable prognostic indicators. ider (9) (q10)t (9;22) (q34;q11.2) is very rare and a recurrent chromosomal abnormality associated with acute lymphoblastic leukemias (ALL) and lymphoblastic crisis of CML. And ider (9) (q10)t (9;22) (q34;q11.2) is a lymphoid-specific rearrangement and the patients with this abnormality are of older age on average. They commonly show pre-B cell lineage immunophenotype and L2 morphology. We report a case of ider (9) (q10)t (9;22) (q34;q11.2) as secondary aberration in a patient with lymphoblastic crisis of CML.
Blast Crisis ; Chromosome Aberrations ; Disease Progression ; Humans ; Leukemia* ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; Philadelphia Chromosome ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Precursor Cells, B-Lymphoid

No abstract available.
Leukemia, Large Granular Lymphocytic*

No abstract available.
Blast Crisis* ; Leukemia*

No abstract available.
Blast Crisis* ; Leukemia*

We have performed analysis of the clinical and epidemic finding in 21 patients diagnosed acute erythroblastic leukemia (M6). M6/AML was 5.9%. The median age was 37.7618.33. Ratio male/female was 0.75 anemia. 4.8% of them had been exposed to possible radiation. 100% of them presented with anemia, 47.5% presented with fever and infection, 42.5% presented with hemorrhage, 38.1% presented symptoms with infiltration. We concluded that acute erythroblastic leukemia has more favorable than AML
Leukemia ; Leukemia, Erythroblastic, Acute ; diagnosis

No abstract available.
Leukemia, Erythroblastic, Acute*

Humans ; Leukemia, Large Granular Lymphocytic

Humans ; Leukemia, Large Granular Lymphocytic

No abstract available.
Leukemia, Erythroblastic, Acute* ; Myelodysplastic Syndromes*

From 3/1999 to 11/2001, 27 patients (age 6-48, 15 males and 12 females) with AML (21 denovo, 4 relape, 2 biphenotype) were treated with induction chemotherapy of 7-3-5 protocol at the blood transfusion and hematology center HCM city. 81.5% (22/27) patients were complete remission but one died on 32th due to fungal infection of the lung, 7.4% patients had no remission, 11.1% patients induction deaths due to infection and GVHD after transfusion. Neutrophil recovery > 0.5x 109/l by allocated treatment is 17 days and platelet > 100x 109/l is 18 days. CR of 7-3-5 protocol is higher than 7-3 protocol. Toxicity of drug is the same.
Leukemia, Erythroblastic, Acute ; therapy ; therapeutics