Between 3/1990 and 5/2000, 249 patients with AML were treated at the Ho Chi Minh center for hematology and blood transfusion. The results were the following: complete remission achieved in 63% patients treated with 7&3 protocol, 77% with 7&3&5 protocol, 8% with Ara-C+ Purinethol protocol and 2% with Ara-C or Purinethol alone protocol. Overall survival at 12 months of patients treated with 7& 3, 7&3&5, and Ara-C+ Purinethol protocol were 32%, 69% and 16%, respectively. Conclusion, induction chemotherapy with 7&3 and 7&3&5 protocols achieved better results in patients with AML.
Leukemia, Myelocytic, Acute ; drug therapy

46 patients with acute promyelocytic leukemia (APL) have been treated by ATRA (all trans retinoic acid). The result showed that 33 patients (72%) were complete remission. Two patients in relapse have been treated by ATRA plus As2O3 (arsenic trioside). The both patients were complete remission. The results of the present study showed that ATRA is standard drug of remission of induction in APL.
Leukemia, Promyelocytic, Acute ; therapy ; drug therapy ; therapeutics

No abstract available.
Drug Therapy* ; Humans ; Leukemia, Myeloid, Acute* ; Mucormycosis*

No abstract available.
Drug Therapy, Combination* ; Humans ; Leukemia, Myeloid, Acute*

Because the oral mucositis is often inevitable in acute leukemia patients during chemotherapy, the efforts must be made to keep these leuekmia patients from oral mucositis. So we tried to develop two oral care protocols for reducing the level of oral mucositis during cytotoxic therapy through literature review and our clinical experience. This quasi-experimental study was performed to compare the prohpylatic value of these oral care protocols. Thirty-seven subjects were assigned to one of three groups. The first group performed bivon-normal saline gargling protocol, the second group performed chlorhexidine gargling protocol, and the last contrast group kept traditional gargling protocol, The Oral Assessment Guide(OAG), the Beck's perception of oral comfort, and the discomfort of oral gargling solution were used to assess oral status and subject's oral discomfort during chemotherapy. Each subjects were observed daily from the start of the chemotherapy until Absolute Nertrophil Count (ANC) reached 1,000/mm3. It continued about 2-4 weeks. The data were analyzed by ANCOVA and Kruskal-Wallis oneway ANOVA. The results were as follows : The control group showed significantly highest mean score of the OAG and Beck's perception of oral discomfort among three groups. However the mean score of OAG and Beck's perception of oral discomfort were not significantly different, the bivon saline group showed significantly lowest mean scores among three groups. In conclusion, we recommend that nurses who care acute leukemia patients use bivon-normal saline gargling protocol to reduce the level of oral mucositis during chemotherapy.
Chlorhexidine* ; Drug Therapy* ; Humans ; Leukemia* ; Stomatitis*

Background: Acute myelogenous leukemia (AML) is the most common disease of malignant hemopathy in adult. Although induction therapy induced the long complete remissions, but complications of this intensive therapy is very serious. Objectives: to evaluate the complications of induction chemotherapy in adult patients with acute myelogenous leukemia at Hue central hospital". Subject and method: 30 AML patients aged from 10 to 30 were treated at clinical hematology service, Hue central hospital from Mars, 2005 to July, 2006. The diagnosis of AML based on FAB classification. Induction therapy consisted of a combination of cytarabin 100mglm2/day given by continuous IV over 7 days and daunorubicin 45mg/m2/day for 3 days. Complications were evaluated based on toxicity grade of WHO. \r\n', u'Results: Alopecia was the most common complications (100%) but good recovery. Gastrointestinal toxicity included: nausea and vomiting (6.6%), oral mucositis (40%) and diarrhea (30%) Cerebral hemorrhage due thrombocytopenia (6.66%) and neutropenic septicemia (20%) are the most severe complications. Acute complications on cardio - vascular system were rare and only mild degree. Conclusion: The complications of induction chemotherapy in adult patients with acute myelogenous leukemia occur at many organs with different degrees. Among of them, bone marrow suppression is the most severe complication with cerebral hemorrhage due thrombocytopenia and neutropenic septicemia which are fatal complications in theses patients. \r\n', u'\r\n', u'
Leukemia ; Myeloid ; Acute/ complications ; pathology ; drug therapy

Analyse chromosome in bone marrow of 66 patients with myeloid leukemia and 27 patients with lymphoblastic leukemia treated in NIHBT from 1997 to 2001, in comparison with result at of some treatment, and duration of remission showed that: In myeloid leukemia, patients with translocation (8q, 21q) and translocation (15q; 17q) have favourable prognostic (they have high rate, long period of remission). In lymphoblastic leukemia, patients with philadelphia chromosome have defavourable prognostic. Although they have remission but short period of remission. It is necessary to look for another way for treatment these patients.
Leukemia ; Chromosome Aberrations ; Drug Therapy ; therapeutics

Clinical Trials as Topic ; Humans ; Leukemia ; drug therapy

No abstract available.
Drug Therapy* ; Leukemia, Myeloid, Acute* ; Nausea* ; Vomiting*

No abstract available.
Cytarabine* ; Drug Therapy, Combination* ; Leukemia, Myeloid, Acute*