We carried out the classification of acute leukemia of 210 adult patients hospitalization at NIHBT during years of 1996-97 by two method of morphocytochemistry and immuno-phenotyping.The purposes are to evaluate the limitations of morphocytochemical method and values of immunophenotyping method to take a part to applicate well this superior method to pathologic study and treatment of acute leukemia in Vietnam. The results showed that there are some special types such as biphenotypic acute leukemia,, null cell AL, stem cell AL and NKAL. 55 out of 210 patients have to correct the result of morpho-cytochemistry by immunophenotyping. Even in common morphological subtypes, it is seen also some mistakes of classfication by the limitation of this method. Immunophenotyping method will define well on M0 subtype, really cellular lineage of ALL, mixed AL, stem cell AL and NK AL.These subtype could not be defined by morphocytochemical method
Leukemia ; diagnosis

At the blood transfusion and haematology centre of HCM, we performed phenotyping for 118 cases of acute leukemia diagnosed from 1/11/1999 to 31/7/2000. Based on the results, we go futher to choose appropriate treatment protocol and prognosis.
Leukemia ; diagnosis

We have performed analysis of the clinical and epidemic finding in 21 patients diagnosed acute erythroblastic leukemia (M6). M6/AML was 5.9%. The median age was 37.7618.33. Ratio male/female was 0.75 anemia. 4.8% of them had been exposed to possible radiation. 100% of them presented with anemia, 47.5% presented with fever and infection, 42.5% presented with hemorrhage, 38.1% presented symptoms with infiltration. We concluded that acute erythroblastic leukemia has more favorable than AML
Leukemia ; Leukemia, Erythroblastic, Acute ; diagnosis

From 1996 to 2000, 609 patients of acute leukemia in NIHBT, Bach Mai hospital were applied immunophenotype. The results as follow: Acute myeloid leukemia (AML): 408 patients (67%) including: AML (CD14-): 367patients (60.3%), AML (CD14+): 41patients (6.7%). Acute lymphoid leukemia (ALL): 123 patients (20.2%) including: PreT: 16 patients (2.6%), T: 3 patients (0.5%), Early B: 2 patients (0.3), PreB: 81 patients (13.3%), 21 patients (3.45%), 78 patients (only CD34+). NK acute leukemia: 1 patient (CD16/56+), Acute “null-cell” leukemia: 17 (all CDs negative on blasts), Mixed acute leute leukemia myoloid-B: 16 patients (CD13+, CD33+ and /or CD3; CD7+), Mixed acute leukemia myeloid-NK: 7 patients (CD13+, CD33+ and/or CD16/56+). These results contributed effectively to pathological study, folow up treatment and prognosis of acute leukemia
Leukemia ; immunology ; diagnosis

The study was carried out on 61 chronic myelo-granulocytic leukemia (CML) patients aimed to investigate the cytological features of peripheral blood. The results showed that all patients had laboratory features of normocytic and normochromic anemia (RBC counts: 2.8T/L +/- SD 0.59). All patients have increased WBC and platelet counts (WBC count: 210.5G/L +/- SD 101.0, platelet count: 624.3G/L +/- SD 431.9). The differentiated white cells showed all types of granulocytic cell (myeloblast 1.5%, promyelocytes 4%, myelocytes 15.5%, metamyelocytes 14.8%, band forms 7.1%, segmented neutrophils 44.9%, basophils 3.3%, eosinophils 2.4%, lymphocytes 5.4%, monocytes 0.1%) with the increase on absolute number and percentage of basophil and eosinophil. However, there was no elevation in myelocyte count compared with metamyelocyte count
Leukemia ; diagnosis ; Cytology ; blood

The sudy of 92 acute leucemia patients at Viet Tiep Hospital from 1998 to 2000, suburb 57.6%, urban 42.4%, sex ratio is similar, farmers 46.74%. Clinical signs: pale skin and mucosa 98.91%, fever 86.96%, skin haemorrhage 52.17%, large liver 51.08%, bubo 47.83%.... Test signs: low erythrocyte 98.91%, low hemoglobin 98.91%, increase leucocyte 60.87%, low glomerule 87.76%, increase marrow cell 58.9%. The result of treatment: 88.04% cases were blood transfusion, merely prednison 43.4%, VAMP 22.83%, ARAC-DNA 14.13%, antibiotic 97.83%. The therapeutic time of 10 - 30 days are 56.53%
Diagnosis ; Therapeutics ; Leukemia

Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disorder of the primitive hematopoietic stem cell. The research is performed to examine the effectiveness of hydroxyurea in treating patients with CML in chronic stage. The results showed that hydroxyurea dramatically improved clinical and hematological condition. All patients reached complete or partial remission
Leukemia ; Hydroxyurea ; therapeutics ; blood ; diagnosis

From January 1997 to January 1998, there were 21 patients with chronic myelogenous leukemia who admitted to the Clinical Department, National Institute of Hematology and Blood Transfusion, B¹ch Mai Hospital. Mean age of patients was 42.85 for men and 38.12 for women. Among these patients, splenomegaly was observed in 100% of patients. Hyperleukocytosis, hyperthrombocytemia, erythrocytopenia, and hyperuricemia all were measured. 94% of patients were positive with Philadelphia chromosome
Leukemia ; Hydroxyurea ; Hematologic Agents ; diagnosis

Humans ; Leukemia, Hairy Cell/diagnosis* ; Diagnosis, Differential

Specific cutaneous infiltrates in chronic lymphocytic leukemia(CLL) presenting as tumor and large nodule on face, scalp and upper trunk and involvement of oral mucsa is extremly rare. In 7% of cases, leukemic infiltrates of the skin precede the diagnosis of Leuke. We report herein leukemic macrocheilia which occured 3 years before a diagnosis of CLL.
Diagnosis ; Leukemia ; Leukemia, Lymphocytic, Chronic, B-Cell* ; Scalp ; Skin