2.Current strategies in the diagnosis and management of chronic neutrophilic leukemia.
Altangerel OTGONBAT ; Mingfeng ZHAO
Chinese Medical Journal 2014;127(24):4258-4262
OBJECTIVETo review the implications for diagnosis, pathogenesis and potential for new therapeutic option for chronic neutrophilic leukemia (CNL).
DATA SOURCESData cited in this review were obtained mainly from PubMed and Medline from 1993 to 2013 and highly regarded older publications were also included. The terms "chronic neutrophilic leukemia" and "diagnosis" were used for the literature search.
STUDY SELECTIONWe identified, retrieved and reviewed the information on the clinical and laboratory features, the new genetic findings, prognosis and disease evolution and management of CNL.
RESULTSThe discovery of high-frequency granulocyte-colony stimulating factor receptor (CSF3R) mutations in CNL identifies a new major diagnostic criterion, and lends more specificity to the World Health Organization (WHO) diagnostic criteria for CNL, which are variably applied in routine clinical practice.
CONCLUSIONSIn patients for whom the cause of neutrophilia is not easily discerned, the incorporation of CSF3R mutation testing can be a useful point-of-care diagnostic to evaluate the presence of a clonal myeloid disorder, as well as providing the potential for genetically informed therapy. The oncogenic CSF3R mutations are molecular markers of sensitivity to inhibitors of the SRC family-TNK2 and JAK kinases and may provide a new avenue for therapy.
Carrier Proteins ; genetics ; Female ; Humans ; Leukemia, Neutrophilic, Chronic ; diagnosis ; genetics ; Male ; Mutation ; Nuclear Proteins ; genetics ; Receptors, Colony-Stimulating Factor ; genetics
3.T618I-Mutated Colony Stimulating Factor 3 Receptor in Chronic Neutrophilic Leukemia and Chronic Myelomonocytic Leukemia Patients who Underwent Allogeneic Stem Cell Transplantation.
Sung Eun LEE ; Irene JO ; Woori JANG ; Yonggoo KIM ; Kyungja HAN ; Myungshin KIM
Annals of Laboratory Medicine 2015;35(3):376-378
No abstract available.
Adult
;
Bone Marrow/pathology
;
DNA Mutational Analysis
;
Humans
;
Leukemia, Myelomonocytic, Chronic/*diagnosis/genetics/therapy
;
Leukemia, Neutrophilic, Chronic/*diagnosis/genetics/therapy
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Leukocyte Disorders/diagnosis
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Male
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Middle Aged
;
Mutation
;
Prognosis
;
Receptors, Colony-Stimulating Factor/*genetics
;
Recurrence
;
*Stem Cell Transplantation
;
Transplantation, Homologous
Result Analysis
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