1.Constitutional Chromosomal Abnormality Identified in a Sibling Donor After Bone Marrow Stem Cell Transplantation in a Pediatric Patient with Acute Megakaryoblastic Leukemia.
Bo Young SEO ; Hyun Woo CHOI ; Min Gu KANG ; Duck CHO ; Seung Jung KEE ; Soo Hyun KIM ; Jong Hee SHIN ; Soon Pal SUH ; Dong Wook RYANG ; Myung Geun SHIN
Annals of Laboratory Medicine 2015;35(1):162-164
No abstract available.
Bone Marrow/pathology
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*Bone Marrow Transplantation
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Child, Preschool
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Chromosomes, Human, Pair 11
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Chromosomes, Human, Pair 2
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Humans
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Infant
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Karyotyping
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Leukemia, Megakaryoblastic, Acute/genetics/*therapy
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Male
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Siblings
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Tissue Donors
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Translocation, Genetic/*genetics
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Transplantation, Homologous
2.Development of Acute Megakaryoblastic Leukemia with Isochromosome (12p) after a Primary Mediastinal Germ Cell Tumor in Korea.
Nae YU ; Hye Ryoun KIM ; Young Joo CHA ; Eun Kyung PARK ; Jeong Wook KIM
Journal of Korean Medical Science 2011;26(8):1099-1102
The association of hematological malignancies with a mediastinal germ cell tumor (GCT) is very rare. We report one case of a young adult male with primary mediastinal GCT who subsequently developed acute megakaryoblastic leukemia involving isochromosome (12p). A 25-yr-old man had been diagnosed with a mediastinal GCT and underwent surgical resection and adjuvant chemotherapy. At 1 week after the last cycle of chemotherapy, his peripheral blood showed leukocytosis with blasts. A bone marrow study confirmed the acute megakaryoblastic leukemia. A cytogenetic study revealed a complex karyotype with i(12p). Although additional chemotherapy was administered, the patient could not attain remission and died of septic shock. This case was definitely distinct from therapy-related secondary leukemia in terms of clinical, morphologic, and cytogenetic features. To our knowledge, this is the first case report of a patient with mediastinal GCT subsequently developing acute megakaryoblastic leukemia involving i(12p) in Korea.
Adult
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Antineoplastic Combined Chemotherapy Protocols/therapeutic use
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Bleomycin/administration & dosage
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Bone Marrow/pathology
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*Chromosomes, Human, Pair 12
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Cisplatin/administration & dosage
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Etoposide/administration & dosage
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Humans
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Isochromosomes
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Karyotyping
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Leukemia, Megakaryoblastic, Acute/drug therapy/etiology/*genetics
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Male
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Mediastinal Neoplasms/*diagnosis/drug therapy/surgery
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Neoplasms, Germ Cell and Embryonal/*diagnosis/drug therapy/surgery
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Neoplasms, Second Primary/drug therapy/etiology/*genetics
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Republic of Korea
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Shock, Septic/pathology