1.Autoimmune hemolytic anemia associated with B-cell chronic lymphoproliferative disorders.
Yun ZHUANG ; Lei FAN ; Yun-Feng SHEN ; Wei XU ; Jian-Yong LI
Journal of Experimental Hematology 2013;21(3):633-636
This study was purpose to investigate the clinical characteristics of B-cell chronic lymphoproliferative disorders (B-CLPD) complicated by autoimmune hemolytic anemia (AIHA) so as to improve the understanding of this disease. The clinical characteristics, laboratory data, therapy and outcome of 14 patients suffering from B-CLPD complicated by AIHA were retrospectively analyzed in Wuxi People Hospital and the First Affiliated Hospital of Nanjing Medical University from 2000 to 2012. The results showed that 9 cases of the 14 patients were patients with chronic lymphocytic leukemia (CLL), 5 cases were patients with lymphoma, at time of hemolysis the median level of hemoglobin was 61 (33 - 84)g/L, the median ratio of reticulocytes was 12.0 (3.1 - 35.0)%, the positive rate of Coombs test was 100%. 1 case received corticosteroid alone, 5 cases were treated with chemotherapy combined with corticosteroid, 8 cases were treated with immunochemotherapy rituximab combined with corticosteroid. Overall response rate was 100%, in which CR was 78.6% (11/14), PR was 21.4% (3/14). The follow-up for these patients were performed to now, 35.7% (5/14) patients relapsed with hemolysis again, but they showed therapeutic response to treatment with above-mentioned therapy. From patients treated with rituximab alone, only 1 patient relapsed. Among 14 patients, 6 cases died, 1 case was lost, the other cases are still alive. It is concluded that the AIHA is the commonest complication of B-CLPD, it can be observed at different stages of B-CLPD, the treatment with corticosteroids can give well therapeutic effect for these patients, but the long time CR is lower, the rituximab has been confirmed to be effective for B-CLPD complicated by AIHA.
Adrenal Cortex Hormones
;
therapeutic use
;
Adult
;
Aged
;
Anemia, Hemolytic, Autoimmune
;
complications
;
diagnosis
;
therapy
;
Antibodies, Monoclonal, Murine-Derived
;
therapeutic use
;
Female
;
Humans
;
Leukemia, Lymphocytic, Chronic, B-Cell
;
complications
;
diagnosis
;
therapy
;
Male
;
Middle Aged
;
Retrospective Studies
;
Rituximab
;
Young Adult
2.Multiple lymphomatous polyposis of intestine: report of a case.
Cai-qin WANG ; Zhong-xin SHI ; Jing JIANG ; Ji-hong ZHANG ; Ying ZHANG ; Qian WANG
Chinese Journal of Pathology 2011;40(5):341-342
Antigens, CD20
;
metabolism
;
CD5 Antigens
;
metabolism
;
Colonic Neoplasms
;
complications
;
metabolism
;
pathology
;
surgery
;
Cyclin D1
;
metabolism
;
Diagnosis, Differential
;
Female
;
Humans
;
Ileal Diseases
;
complications
;
pathology
;
surgery
;
Ileocecal Valve
;
Intestinal Neoplasms
;
complications
;
metabolism
;
pathology
;
surgery
;
Intestinal Polyps
;
complications
;
metabolism
;
pathology
;
surgery
;
Intussusception
;
complications
;
pathology
;
surgery
;
Leukemia, Lymphocytic, Chronic, B-Cell
;
metabolism
;
pathology
;
Lymphoma, Mantle-Cell
;
complications
;
metabolism
;
pathology
;
surgery
;
Middle Aged
3.Hepatitis B virus reactivation during chlorambucil and prednisolone treatment in an HBsAg-negative and anti-HBs-positive patient with B-cell chronic lymphocytic leukemia.
Sung Min LIM ; Jeong Won JANG ; Byung Wook KIM ; Hwang CHOI ; Kyu Yong CHOI ; Soo Jeong PARK ; Chi Wha HAN
The Korean Journal of Hepatology 2008;14(2):213-218
It is generally accepted that seroconversion of hepatitis B virus (HBV) surface antigen (HBsAg) to an antibody to HBsAg (anti-HBs) indicates clearance of HBV. Here we report a case of severe hepatitis that manifested during chemotherapy in a female patient with chronic lymphocytic leukemia (CLL) who had been initially seronegative for HBsAg and seropositive for anti-HBs. The patient received chlorambucil and prednisolone for the treatment of CLL. After 6 months the serum levels of aminotransferases were increased, and HBsAg and HBV DNA were present in serum. Lamivudine was administered immediately after confirming the HBV reactivation, which considerably improved jaundice and aminotransferase levels after 3 weeks. The patient was able to resume the chemotherapy whilst continuing lamivudine treatment. This case report highlights the need for physicians to be aware of the potential risk of HBV reactivation even in an HBsAg-negative person but with detectable anti-HBc and/or anti-HBs, underscoring the need for future studies that explore the role of antiviral prophylaxis in this setting.
Aged
;
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
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Chlorambucil/*therapeutic use
;
Female
;
Hepatitis B/*diagnosis/virology
;
Hepatitis B Antibodies/*blood/immunology
;
Hepatitis B Surface Antigens/*blood/immunology
;
Hepatitis B virus/isolation & purification/physiology
;
Humans
;
Leukemia, Lymphocytic, Chronic, B-Cell/complications/*drug therapy
;
Prednisolone/*therapeutic use
;
Virus Activation
4.Capnocytophaga sputigena Bacteremia in a Patient with Chronic Lymphocytic Leukemia.
Jung Ah KIM ; Sung Kuk HONG ; Eui Chong KIM
Annals of Laboratory Medicine 2014;34(4):325-327
No abstract available.
Adult
;
Anti-Bacterial Agents/pharmacology/therapeutic use
;
Bone Marrow Transplantation
;
Capnocytophaga/drug effects/genetics/*isolation & purification
;
Gram-Negative Bacterial Infections/complications/*diagnosis/drug therapy
;
Humans
;
Leukemia, Lymphocytic, Chronic, B-Cell/complications/*diagnosis
;
Male
;
Microbial Sensitivity Tests
;
Penicillanic Acid/analogs & derivatives/pharmacology/therapeutic use
;
Piperacillin/pharmacology/therapeutic use
;
RNA, Ribosomal, 16S/chemistry/metabolism
;
Sequence Analysis, RNA
;
Sequence Homology, Nucleic Acid
;
Transplantation, Homologous
;
Treatment Outcome