1.Acute Lymphoblastic Leukemia Associated with Brucellosis in Two Patients with Fever and Pancytopenia.
Bulent ESER ; Fevzi ALTUNTAS ; Isin SOYUER ; Ozlem ER ; Ozlem CANOZ ; Hasan Senol COSKUN ; Mustafa CETIN ; Ali UNAL
Yonsei Medical Journal 2006;47(5):741-744
Brucellosis is a disease involving the lymphoproliferative system, which may lead to changes in the hematological parameters; however, pancytopenia is a rare finding. However, malignant diseases in association with brucellosis are rarely the cause of pancytopenia. Herein, two cases with fever and pancytopenia, diagnosed as simultaneous acute lymphoblastic leukemia and brucellosis are presented. Anti-leukemic therapy and brucellosis treatment were administered simultaneously, and normal blood parameters obtained. The first patient is in complete remission; the other recovered from the brucellosis, but later died due to a leukemic relapse.
Pancytopenia/diagnosis/*etiology/therapy
;
Leukemia, Lymphocytic, Acute/*complications/pathology/therapy
;
Humans
;
Fever
;
Female
;
Brucellosis/*complications/diagnosis/therapy
;
Adult
2.Fungal discitis due to Aspergillus terreus in a patient with acute lymphoblastic leukemia.
Kyoung Un PARK ; Hye Seung LEE ; Chong Jai KIM ; Eui Chong KIM
Journal of Korean Medical Science 2000;15(6):704-707
We report a case of Aspergillus terreus discitis which developed in a patient with acute lymphoblastic leukemia following induction chemotherapy. A. terreus was isolated from sputum, one month earlier, but the physician did not consider it significant at the time. Magnetic resonance imaging study showed the involvement of L3-4, L4-5 and L5-S1 intervertebral discs. Etiology was established by means of histology and culturing a surgical specimen of disc materials. Our patient survived after a surgical debridement and amphotericin B administration with a total dose of 2.0 g. Discitis caused by Aspergillus terreus is a very rare event. A. terreus is one of the invasive Aspergillus species. The pathogenetic mechanism is discussed and the literature is reviewed.
Aspergillosis/surgery
;
Aspergillosis/pathology
;
Aspergillosis/microbiology*
;
Aspergillosis/drug therapy
;
Aspergillosis/complications
;
Aspergillus/isolation & purification
;
Aspergillus/classification
;
Journal Article
;
Discitis/surgery
;
Discitis/pathology
;
Discitis/microbiology*
;
Discitis/drug therapy
;
Human
;
Intervertebral Disk/surgery
;
Intervertebral Disk/pathology
;
Intervertebral Disk/microbiology*
;
Leukemia, Lymphocytic, Acute/microbiology
;
Leukemia, Lymphocytic, Acute/drug therapy
;
Leukemia, Lymphocytic, Acute/complications*
;
Lumbar Vertebrae/surgery
;
Lumbar Vertebrae/pathology
;
Lumbar Vertebrae/microbiology*
3.Hodgkin's disease in a child with acute lymphoblastic leukemia.
Ho Seung KIM ; Hye Ok ROH ; Shin Heh KANG ; Chuhl Joo LYU ; Kir Young KIM ; Soon Won HONG ; Woo Ick YANG
Yonsei Medical Journal 1991;32(3):270-274
Hodgkin's disease, manifested as a second malignant neoplasm in acute lymphoblastic leukemia, rarely occurs, with seventeen cases reported including this cases. We presented the clinical and pathological features of a nine-year-old male child with acute lymphoblastic leukemia in remission. He had cervical lymph node involvement 22 months after the diagnosis of leukemia as an initial presentation of Hodgkin's disease of mixed cellularity. A brief review of related literatures was also done.
Antineoplastic Agents/administration & dosage
;
Case Report
;
Child
;
Hodgkin Disease/*complications/pathology
;
Human
;
Leukemia, Lymphocytic, Acute/*complications/drug therapy/pathology
;
Male
;
Neoplasms, Second Primary/pathology
4.Five cases of cytomegalovirus infection detected by in situ hybridization and antigenemia assay.
Jin Hong YOO ; Jong Young CHOI ; Yang Ree KIM ; Yeong Jin CHOI ; Sang In SHIM ; Hak Ki KIM ; Chul Woo YANG ; Yong Soo KIM ; Chi Wha HAHN ; Wan Shik SHIN ; Chong Won PARK ; Moon Won KANG ; Choon Choo KIM ; Byung Kee BANG ; Dong Jip KIM
Journal of Korean Medical Science 1994;9(6):507-512
We report five cases of cytomegalovirus infection in immunocompromised patients which were detected by either cytomegalovirus antigenemia assay or in situ hybridization. Four cases had leukemia and the other had chronic renal failure. All the three BMT recipients suffered from GvHD. Interestingly, there was an unique case of CMV disease without a history of BMT, which reminded us that CMV could attack immunocompromised patients who had not undergone transplantation, too. Four out of five cases died. We think that cytomegalovirus infection or disease should not be regarded as a minor problem in post-transplantation infection in Korea.
Adolescent
;
Adult
;
Antigens, Viral/*blood
;
*Bone Marrow Transplantation
;
Case Report
;
Cytomegalovirus/*immunology
;
Cytomegalovirus Infections/complications/*diagnosis
;
Fatal Outcome
;
Graft vs Host Disease/complications
;
Human
;
Immunocompromised Host
;
In Situ Hybridization
;
Kidney Failure, Chronic/complications
;
Kidney Transplantation
;
Leukemia/*complications/therapy
;
Leukemia, Lymphocytic, Acute, L2/complications/therapy
;
Leukemia, Myelocytic, Acute/complications/therapy
;
Leukemia, Myeloid, Chronic/complications/therapy
;
Male
;
Viremia/*diagnosis
5.Prognostic Factors Influencing Infection-related Mortality in Patients with Acute Leukemia in Korea.
Jin Hong YOO ; Su Mi CHOI ; Dong Gun LEE ; Jung Hyun CHOI ; Wan Shik SHIN ; Woo Sung MIN ; Chun Choo KIM
Journal of Korean Medical Science 2005;20(1):31-35
We retrospectively reviewed the medical records of 284 patients with neutropenic fever following chemotherapy for acute leukemia at the Catholic Hematopoietic Stem Cell Transplantation Center from January 1998 to December 1999, to identify prognostic factors for infection related mortality. Twenty-eight patients died of infections. There was no difference in median age, gender ratio, or underlying disease between the dying and surviving groups. Bacteria were the main pathogens following chemotherapy, and Gram positive organisms predominated in the dying group. Pneumonia and sepsis were the main causes of death. There were 72 cases of invasive fungal infection and their mortality was 27.8%. Invasive fungal infection and previous history of fungal infection were independent prognostic factors for outcome. Recovery from neutropenia was the significant protective factor for mortality. In conclusion, the prognostic factors identified in this study could be useful for deciding on more intensive treatment for those patients at greater risk of death. To our knowledge, this is the first Korean study delineating prognostic factors in acute leukemic patients with infectious complications.
Adolescent
;
Adult
;
Aged
;
Bacterial Infections/complications/*mortality
;
Cause of Death
;
Female
;
Humans
;
Korea
;
Leukemia
;
Leukemia, Lymphocytic, Acute/complications/*microbiology/*mortality
;
Leukemia, Myelocytic, Acute/complications/*microbiology/*mortality
;
Male
;
Middle Aged
;
Morbidity
;
Multivariate Analysis
;
Mycoses/complications/mortality
;
Neutropenia
;
Pneumonia/complications/mortality
;
Prognosis
;
Retrospective Studies
;
Sepsis/complications/mortality
;
Survival Rate