No abstract available.
Leukemia, Erythroblastic, Acute*

We have performed analysis of the clinical and epidemic finding in 21 patients diagnosed acute erythroblastic leukemia (M6). M6/AML was 5.9%. The median age was 37.7618.33. Ratio male/female was 0.75 anemia. 4.8% of them had been exposed to possible radiation. 100% of them presented with anemia, 47.5% presented with fever and infection, 42.5% presented with hemorrhage, 38.1% presented symptoms with infiltration. We concluded that acute erythroblastic leukemia has more favorable than AML
Leukemia ; Leukemia, Erythroblastic, Acute ; diagnosis

No abstract available.
Leukemia, Erythroblastic, Acute* ; Myelodysplastic Syndromes*

From 3/1999 to 11/2001, 27 patients (age 6-48, 15 males and 12 females) with AML (21 denovo, 4 relape, 2 biphenotype) were treated with induction chemotherapy of 7-3-5 protocol at the blood transfusion and hematology center HCM city. 81.5% (22/27) patients were complete remission but one died on 32th due to fungal infection of the lung, 7.4% patients had no remission, 11.1% patients induction deaths due to infection and GVHD after transfusion. Neutrophil recovery > 0.5x 109/l by allocated treatment is 17 days and platelet > 100x 109/l is 18 days. CR of 7-3-5 protocol is higher than 7-3 protocol. Toxicity of drug is the same.
Leukemia, Erythroblastic, Acute ; therapy ; therapeutics

An analysis of the morphologic characteristics was performed in 21 patients diagnosed acute erythroblastic leukemia (M6). The result showed that 95.2% of them had nucleated red cell and blast in the peripheral blood. The percentage of nucleated red cell in the peripheral blood was 17.571+/-4.04. Reticulocytes was 0.5+/-0.11% in peripheral blood. (proerythroblast + basophilic erythroblast) was 32+/-8.4%. (Polychromatic erythroblast + orthochromatic erythroblast) was 30.238+/-8.86%.
Leukemia, Erythroblastic, Acute ; Bone Marrow ; diagnosis

No abstract available.
Cell Line* ; Cell Proliferation* ; Cytokines ; Leukemia, Erythroblastic, Acute*

OBJECTIVETo report a case of pure erythroid leukemia.

METHODSThe clinical features, treatment and prognosis of a rare case of pure erythroid leukemia were reported, and the related literature was reviewed.

RESULTSThe pure erythroid leukemia patient was diagnosed by 90.4% pronormoblasts in bone marrow, 99.5% for erythroid antigen CD71, 67.4% for glycophorin A were detected, while no differentiation antigen of myeloid, lymphoid and megakaryocyte lineages were observed. HAG (homoharringtonine + Cytarabine and G-CSF) regimen were administered with no effect. The patient developed multiple organ failure and died soon.

CONCLUSIONPure erythroid leukemia has a fulminant clinical course with poor response to chemotherapy and worse prognosis.

We report a case of acute myelogenous leukemia (AML) developed in a human immunodeficiency virus-infected patient, which is a very rare event. The subtype of AML was initially determined as AML M6a (French-American-British classification), but it was transformed into AML M5b in the course of treatment. Blasts showed very intense staining with periodic acid-Schiff and multiple complex chromosomal abnormalities in the karyotype.
Chromosome Aberrations ; HIV ; Humans ; Karyotype ; Leukemia, Erythroblastic, Acute* ; Leukemia, Myeloid, Acute

BACKGROUND: Ionizing radiation is a group 1 carcinogen according to the IARC(International Agency for Research on Cancer) classification. With the development of the radiation related industry, the number of radiation exposed workers has been increasing. There have been several reports on AML(Acute Myeloid Leukemia) on exposure to ionizing radiation; however, there are no reports of occupational malignant lymphohematopoietic disease related to non-destructive inspection. CASE REPORT 1: A 35-years-old male, who had worked for 10 years in non-destructive inspection, was diagnosed with myelodysplastic syndrome. He worked 8 hours a day, for three weeks per months, where he was exposed to 192Ir and 60Co radiation sources. Because he had not worn a film badge for monitoring his radiation exposure dose, the accurate exposure dose was not reported. The estimate exposure dose calculated via a chromosomal study was 1.20 Gy, which exceed the dose limits of Korean radiation dose standards, which are 50 and 100 mSv annually and quinquennially respectively. CASE REPORT 2: A 26-years-old male, who had worked for 2.5 years in the same company was also diagnosed with myelodysplastic syndrome. CONCLUSION: Non-destructive inspection is the main source of ionizing radiation in the workplace, which could be the cause of malignant lymphohematopoietic diseases. Therefore, more practical plans and guidelines are needed to prevent non-destructive inspectors from workplace radiation exposure.
Film Dosimetry ; Humans ; Leukemia ; Leukemia, Erythroblastic, Acute ; Male ; Myelodysplastic Syndromes ; Radiation, Ionizing

It is well known that the Ebstein-Barr virus causes not only infectious mononucleosis in the most cases, but also occasionally causes a variety of hematologic disorders such as anemia (hemolytic anemia or aplastic anemia), thrombocytopenia, neutropenia and malignancies such as Burkitt lymphoma and nasopharyngeal carcinoma. Furthermore, recently it is has been reported that it causes leukemia even though very rarely. The authors report a case of erythroleukemia possibly related to chronic Ebstein-Barr virus infection in a 14-year-old boy with brief review of related literatures.
Adolescent ; Anemia ; Burkitt Lymphoma ; Humans ; Infectious Mononucleosis ; Leukemia ; Leukemia, Erythroblastic, Acute* ; Male ; Neutropenia ; Thrombocytopenia