Systemic lupus erythematosus (SLE) is a severe systemic autoimmune disease, which is characterized by excessive production of autoantibodies caused by B cell hyperactivity. Thus,reducing au-toantibody production can control the development of SLE,and understanding the molecular and cellular fac-tors involved in the differentiation of B cells will provide new therapeutic targets. Follicular helper T cells (Tfh) are defined as a new subset of CD4+T cells specialized in providing help to B cells,which is suspec-ted to play a critical role in the pathogenesis of SLE. In the present review,we give an overview of key mole-cules involved in the differentiation,regulation and functions of Tfh,discuss the roles of Tfh in SLE and de-scribe some potential therapeutic targets for SLE.

Objective To investigate the effects of psychological intervention on relieving the emotional state and improving life quality for patients with leukemia during clinical nursing.Methods A total of 120 cases of leukemia were collected to follow up one year,and were divided into routine treatment group (60 cases) and psychological intervention group (60 cases) respectively.The emotional states of both groups were compared using hospital anxiety and depression scale (HADS),while the life quality of patients was assessed andcompared by quality of life questionnaire (EORTC-QLQ).Results Mter one year of follow-up,the mean HADS score of routine treatment group was (8.3 ± 3.2),whereas that of psychological intervention group was (6.2 ± 4.1) with significant difference between two groups (P ＜ 0.05).The assessments of overall health status,role function,emotional function and social function from EORTC-QLQ for both groups patients were significantly different after one-year follow-up (P ＜ 0.05).The HADS scores of patient with different types of leukemia varied statistically as well (P ＜ 0.01).Conclusions Psychological intervention for patients with leukemia during treatment can relieve the symptoms of depression significantly and improve the quality of life,which is prognosis favorable.

Objective To analyze the effects of "whole-jobs" double tutorial system in clinical nursing teaching.Methods A total of 120 nursing students in the Second Affiliated Hospital of Wenzhou Medical University from 2013 to 2015 were randomly divided into the experimental group and control group with 60 cases respectively. Control group used the traditional "jobs" teacher teaching mode, while the experimental group adopted "whole-jobs" double tutorial system teaching mode. Clinical comprehensive ability and the nursing students' evaluation of the teaching mode were compared between two groups.Results After the practice, the score of the clinical comprehensive ability of the nursing students in the experimental group was (87.54±2.09), while the score in the control group was (73.89±2.15). There was statistically significant difference between two groups (t=1.781,P<0.05). The satisfaction rates of nurses to the clinical "whole-jobs" were 96.7% in the experimental group and 90.0% in the control group, with statistically significant difference between two groups (χ2=6.287,P<0.05).Conclusions The "whole-jobs" double tutorial system has significant teaching effects, with a high satisfaction of nursing students to the clinical teaching method, thus it can be promoted in clinical teaching of nursing students.

Objective To identify the clinical characteristics and therapeutic effect of systemic lupus erythematosus (SLE) patients with diffuse alveolar hemorrhage (DAH).Methods Clinical characteristcs,diagnosis,treatment and outcome in 34 patients hospitalized in The First Affiliated Hospital of Guangxi Medical University from January 2006 to December 2016 were retrospectively analyzed.Results The incidence of DAH involvement of SLE was about 0.39％.Median age was 19 (interquartile range (IQR) 11.75 ～ 32) years.The duration of SLE before clinical DAH was 6 months (IQR 2 ～ 15.75) months.The main clinical manifestations of DAH were cough,dyspnea and fever.The SLE disease activity index (SLEDAI) score was 19.5 (16 ～ 25)points and anti-dsDNA antibody titer elevated markedly (38.2％).The overall mortality rate was 73.5％,however patients who chose department of rheumatism have lower mortality (52.9％).And treatment of CTX was associated with mortality (OR =0.059,95％ CI 0.006 ～ 0.554,P =0.013),as well as steroids and immunosuppressant combination therapy.Conclusions The clinical symptoms of SLE with DAH is often atypical.There is manifestation of cough,fever,dyspnea and etc.Imaging and broncoscopy can assist the diagnosis and its prone to the pulmonary infection and high mortality.Early diagnosis and application of CTX combined with conventional dose of hormone theraphy can in early diagnosis and reduce the mortality.