The weightlessness effect during space flight can cause damage to the astronaut's body,and this damage requires a longer recovery time even after the astronaut returns to Earth,and even irreversible damage may occur.Mitochondria are important organelles within cells,participating in regulating a range of important physiological and biochemical processes.Mitochondrial mediated metabolic regulation can sense microgravity stress,which is an early intracellular response caused by microgravity,promoting the adaptation of intracellular metabolism and stress-induced damage.This article reviews the research progress on the effects and related mechanisms of microgravity and simulated microgravity on cell mitochondria,providing a theoretical basis for the development of protection strategies targeting mitochondria.

This paper analyzed the traditional Chinese medicine （TCM） and western medical understanding of coronary microvascular disease （CMVD） from the three dimensions of "disease-syndrome-symptom". In western medicine， by summarizing the suspected diagnosis and understanding of CMVD， it is believed that inflammatory responses and vascular endothelial damage are the key mechanisms of the pathogenesis. From the perspective of TCM， the disease location is at blood， vessels and heart， and the fundamental cause is spleen and kidney depletion， closely realted to phlegm， stasis， toxin， wind and qi. Integrating the understanding of both TCM and western medicine， clinical treatment advocates taking the CMVD pathology as the base， and the TCM understanding of pathogenesis as the main focus. The properties of Chinese herbal medicinals is used as the guidance for medication， and the pharmacological understanding as the assisstance of treatment， with the medical history and the severity of the condition are additionally considered. It is finally proposed that during the acute phase， the methods of nourishing yin and resolving toxins， softening hardness and dissipating masses， dispelling wind and unblocking collaterals should be applied to alleviate the emergency. In the subacute phase， the focus should be on raising and lifting qi promote its movement， with flexible use of medicinals that can unblock yang. In the remission phase， the method of tonifying spleen and fortifying kidney should be used to maintain the stability of the condition.