1.Efficacy and Safety of Jieyu Anshen Decoction Combined with Aripiprazole Tablets in Treating Chronic Schizophrenia
Chinese Journal of Biochemical Pharmaceutics 2017;37(9):94-95,97
Objective To explore the clinical effect of Jieyu Anshen decoction combined with aripiprazole tablet in the treatment of chronic schizophrenia. Methods A total of 210 patients with chronic schizophrenia who were treated in our hospital from March 2015 to March 2017 were randomly divided into two groups,with 105 cases in each group. The control group was treated with aripiprazole tablet. The observation group was treated with Jieyu Anshen decoction combined with aripiprazole tablet. The treatment effect was observed and compared. Results There was no significant difference in the clinical condition between the two groups before treatment, and the improvement was more obvious in the observation group after treatment; The effective rate in the observation group (90.47%) was significantly higher than in the control group (80.0%), the difference was statistically significant (P<0.05). There was no significant difference in the safety of the two groups. Conclusion Jieyu Anshen Decoction combined with aripiprazole tablets in the treatment of chronic schizophrenia compared to conventional methods, can improve clinical efficacy, but also has good safety, it is worth clinical reference.
2.Analysis on the mutation of SLC5A2 gene in Chinese patients with familial renal glucosuria and investigation on the association of genotype and phenotype
Xiaohui WANG ; Xiangzhong ZHAO ; Chunmei LI ; Ying YUAN ; Leping SHAO
Chinese Journal of Nephrology 2016;32(1):1-8
Objective To describe and analyze the clinical characters of patients with FRG from 7 Chinese families.Then analyze and identify their mutations in SGLT2 gene,and explore the association of genotype and phenotype.Methods Quantitative test for 24-hour urine glucose and other laboratory tests were carried out among 7 probands (14 patients in all) and their family members from 7 pedigrees (totaling 23 subjects).All coding regions,including intron-exon boundaries,were analyzed using PCR followed by direct sequence analysis.Results Five novel mutations in SLC5A2 gene were identified in this investigation,including four missense mutations (A Serine to Glycine at position 335 (c.1003A>G,p.S335G),a Glutamine to Arginine at position 448 (c.1343A > G,p.Q448R),an alanine to proline at position 474 (p.A474P,c.1420G > C) and a glycine to aspartic acid at position 580 (c.1739G > A,p.G580D) and a deletion in intron 7 (c.886(-10_-31)del).By the minigene studies using the pSPL3 plasmids,we confirmed the deletion c.886(-10_-31)del as a splicing mutation.In this study,the mutation c.886(-10_-31)del accounted for about 43% of the total alleles (12/28).These patients with compound heterozygous or homozygous mutations manifested middle degree or severe glycosuria (Quantitative test for 24-hour urine glucose:10.56-50.68 g/1.73 m2),however those with heterozygous variants presented with mild to moderate glycosuria (Quantitative test for 24-hour urine glucose ≤ 2.45 g/1.73 m2).This fits co-dominant inheritance pattern.Conclusions Five novel mutations which may be related to FRG are found in this study,and c.886(-10-31) del may be a high frequency mutation in Chinese patients.
3.Effect of repetitive transcranial magnetic stimulation on serum brain derived neurotrophic factor in depressive patients
Jiao YUAN ; Leping XU ; Yuzhi LIU ; Jian SUN ; Aifang ZHONG ; Zhi LIN
Chinese Journal of Behavioral Medicine and Brain Science 2013;(3):228-230
Objective To explore the effect of repetitive transcranial magnetic stimulation(rTMS) treatment on the brain derived neurotrophic factor(BDNF) serum levels in depressive patients.Methods Sixty-eight unipolar depressions treated with venlafaxine were randomly assigned to the real rTMS group(n =34)and the sham rTMS group(n =34),which were accepted the real or the shame rTMS treatment on the left dorsolateral prefrontal lobes respectively.The Hamilton Rating Scale for Depression (HAMD) and BDNF serum was assayed before and after 4 weeks' treatment.Results 1) A significant increase of serum BDNF((12.2 ± 1.3) μg/L vs (5.6 ± 0.8) μg/L,t=-9.167,P=0.000;(11.4 ± 1.5)μg/L vs (6.0± 1.0)μg/L,t=-7.421,P=0.000)and a significant decline of HAMD((11.6 ± 1.7) score vs (32.6 ± 2.5) score,t =14.654,P =0.000 ; (4.2 ± 2.8) score vs (31.8 ± 3.2)score,t=12.089,P =0.000) were found after the treatment in the real and the shame group,and the real group changed more significantly than the shame group ((6.7 ± 0.8) μg/L vs (5.1 ± l.2) μg/L,t =2.690,P =0.009 ; (21.0 ± 2.1) score vs (17.6 ± 2.6) score,t =2.693,P =0.000).2) A negative correlation was found between the serum BDNF levels and the HAM D scores before the treatment(r =-0.530,P=0.003; r =-0.490,P =0.004),and a positive correlation between changes of BDNF levels and HAMD scores changes(r =0.439,P =0.006 ; r =0.454,P =0.005).Conclusion The rTMS treatment can increase serum BDNF levels in depressive patients.
4. Diagnosis and treatment of 15 cases of idiopathic subglottic stenosis
Zhihua GUO ; Pengcheng CUI ; Daqing ZHAO ; Leping LIANG ; Jing YANG ; Qianqian ZHAO ; Wei WANG ; Yuan XING
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2020;34(2):173-176
Objective:
The aim of this study is to o explore the diagnosis, treatment and prognosis of idiopathic subglottic stenosis (ISS)
Method:
The clinical data of 15 patients with idiopathic subglottic stenosis treated in our department were analyzed retrospectively. The degree of stenosis was classified by the Cotton Airway grading system of Myer, with 8 cases of gradeⅡ, 4 cases of grade Ⅲ and 3 cases of grade Ⅳ.
Result:
The time of follow-up of HTSS was 0.5-10 years. All 15 patients were successfully extubated without asphyxia, decannulation and wound nonunion.
Conclusion
For patients with idiopathic subglottic stenosis in the non-progressive stage, active surgical treatment strategy should be adopted and treated individually. The prognosis is satisfactory.
5.Diagnosis and treatment of 15 cases of idiopathic subglottic stenosis.
Zhihua GUO ; Pengcheng CUI ; Daqing ZHAO ; Leping LIANG ; Jing YANG ; Qianqian ZHAO ; Wei WANG ; Yuan XING
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2020;34(2):173-176
The aim of this study is to o explore the diagnosis, treatment and prognosis of idiopathic subglottic stenosis (ISS) The clinical data of 15 patients with idiopathic subglottic stenosis treated in our department were analyzed retrospectively. The degree of stenosis was classified by the Cotton Airway grading system of Myer, with 8 cases of gradeⅡ, 4 cases of grade Ⅲ and 3 cases of grade Ⅳ. The time of follow-up of HTSS was 0.5-10 years. All 15 patients were successfully extubated without asphyxia, decannulation and wound nonunion. For patients with idiopathic subglottic stenosis in the non-progressive stage, active surgical treatment strategy should be adopted and treated individually. The prognosis is satisfactory.