Aim: To determine the effect of oral administration of an aqueous extract from the roots of Lepidium meyenii (maca)on spermatogenesis in adult male rats. Methods: Male rats received an aqueous extract of the root (66.7 mg in one mL) twice a day for 14 consecutive days. Results: Treatment with Lepidium meyenii resulted in an increase in the weights of testis and epididymis but not the seminal vesicle weight. The length and frequency of stages IX-XIV seminiferous tubules, where mitosis occurred, were increased and stages Ⅰ-Ⅵ were reduced in rats treated with Lepidium meyenii. Conclusion: The Lepidium meyenii root invigorates spermatogenesis in male rats by acting on its initial stages (IX-XIV).

AIMTo evaluate the effect of the alcoholic extract of Lepidium meyenii (Maca) on the spermatogenesis in male rats.

METHODSIn Holtzman rats, Maca alcoholic extract (5 %) was given by oral route at doses of 48 mg/day or 96 mg/day for 7 days, 14 days and 21 days. Testicular function was assessed by measurements of lengths of different stages of seminiferous epithelia and by epididymal sperm count.

RESULTSEthanolic extract of Maca increased the length of stages IX-XI of seminiferous epithelium at treatment day 7, day 14 and day 21. Progression of spermatogenesis was evident only after day 21 when lengths of stages XII-XIV of seminiferous epithelium were increased; at day 7 and day 14, no important change in spermatogenesis was observed. Epididymal sperm count was increased with 48 mg/day at all times. With 96 mg/day an increase in sperm count was observed at day 7, but it was reduced at day 14 and day 21 of treatment. Serum testosterone levels were not affected.

CONCLUSIONThe alcoholic extract of Maca activates onset ant progression of spermatogenesis at 48 mg/day or 96 mg/day in rats.

Animals ; Epididymis ; cytology ; Ethanol ; Lepidium ; chemistry ; Male ; Plant Extracts ; administration & dosage ; pharmacology ; Rats ; Seminiferous Epithelium ; anatomy & histology ; drug effects ; Sperm Count ; Spermatogenesis ; drug effects ; Testis ; drug effects ; physiology ; Testosterone ; blood