Objective: To study changes of peripheral blood lymphocyte calcineurin/ nuclear factor of activated T cells (CaN/NFAT) signaling pathway and calcium activated potassium channel (KCa3.1) expression in Kazak hypertensive patients with high high sensitive C reactive protein (hsCRP) level from Xinjiang, and explore the mechanism of lymphocyte potassium channel involving in inflammation of hypertension.Methods: Kazak hypertensive patients from Xinjiang, who were first diagnosed in our heart center without antihypertensive therapy from Feb 2014 to Nov 2014, were selected.According to detected hsCRP level, a total of 50 hsCRP≥3mg/L patients were enrolled as high hsCRP group, and 50 hsCRP<3mg/L patients were enrolled as normal hsCRP group.Gene and protein expression levels of KCa3.1 and tumor necrosis factor (TNF)-α, and activities of lymphocyte CaN and NFAT were measured and compared between two groups.Results: Compared with normal hsCRP group, there were significant rise in expression levels of lymphocyte KCa3.1 mRNA [(0.86±0.16) vs.(2.48±0.22)], TNF-α mRNA [(1.02±0.15) vs.(2.90±0.13)], KCa3.1 protein [(1.00±0.02) vs.(2.46±0.04)] and TNF-α protein [(1.01±0.02) vs.(2.04±0.06)], and activities of CaN [(1.04±0.15) vs.(2.83±0.08)] and NFAT [(0.96±0.06) vs.(2.65±0.07)] in high hsCRP group, P<0.01 all.Conclusion: In Kazak hypertensive patients with inflammatory reaction from Xinjiang, KCa3.1 and CaN-NFAT signaling pathway expression rises, suggesting that lymphocyte KCa3.1 may be involved in occurrence and development of hypertension via CaN/NFAT signaling pathway.

Image guided surgery (IGS) means that computers are used for modeling the position of patients and providing the surgeons with image guidance for invasive procedures. In this paper, we introduce the composition and the work flow of IGS, analyze the process and principle of Registration, which is regarded as a process to combine the actual position of patients and the visual position of models. Seeing that the precision of the registration determines the precision of the IGS system directly, we conduct a study on the registration algorithm precision, feasibility as well as robustness. Combined with the actual requirements in clinical IGS, we also analyze the influence of changes in the number and position of markers on registration precision.
Algorithms ; Humans ; Image Processing, Computer-Assisted ; methods ; Imaging, Three-Dimensional ; methods ; Neuronavigation ; Pattern Recognition, Automated ; methods ; Stereotaxic Techniques ; Surgery, Computer-Assisted

With the advent of the Internet era, the development of new technology brings new opportunities for chronic disease management. Through long-term observation research, a large number of literature review and clinical practice and thinking, we have built the chronic disease management model of tertiary hospital centered on internet + doctors, and applied it to the management of patients with chronic diseases such as hypertension, and achieved good results, so as to provide decision-making reference for the construction of chronic disease management model in China.