Objective To investigate the effect of metformin on thyroid hormone and thyrotropin(TSH) in diabetic patients without thyroid hormone replacement.Methods Serum levels of free T3(FT3),free T4(FT4),total T3(TT3),total T4(TT4) and TSH were measured in diabetic patients with or without metformin therapy and the relationship between TSH and metformin was analyzed.Results There were no significant differences in serum FT3(4.65?0.68 vs 4.59?0.67 pmol/L),FT4(17.88?3.26 vs 17.75?2.85pmol/L),TT3(1.79?0.42 vs 1.77?0.38nmol/L),TT4(107.9 ?22.1 vs 109.2?22.1nmol/L) and thyrotropin(ln TSH:0.49?0.83 vs 0.47?0.87 mU/L) between diabetic patients taking and not taking metformin.Conclusions In diabetic patients without thyroid hormone replacement,metformin does not suppress serum TSH.

Objective To study the clinical law and imaging characteristics of intracranial primary malignant lymphoma.Methods The clinical law and imaging finding in 27 cases of intracranial primary malignant lymphoma confirmed by pathology were analysed CT scan was performed in all cases.MRI examination were carried out in 20 cases simultaneously.Results The first symptom in most cases was headache,and other symptoms were epileopsy,dizziness,hemiplegia,etc.This lesion was mostly seen in male around 40 years old.The lesions were mostly equal or high density on CT,equal or low signal intensity on T 1WI and closed to grey matter signal intensity on T 2WI.Tumors were enhanced obviously on contrast-enhanced scans,necrosis of center of focus was seen in 1/3 cases.The lesions were single or multiple.Conclusion The accuray diagnosis of intracranial primary malignant lymphoma can be done by combined clinical data with imaging features.