Objective To investigate the applicability of clinical grade and a non-contact measurement method in evaluation of underneath eye wrinkles and to compare two methods.Methods A lot of 46 healthy Chinese women were recruited for this study.Underneath eye wrinkles severity was evaluated using clinical grade and a non-contact measurement method.The correlations were calculated for clinical grade and non-contact measurement parameters and age.The non-contact measurement parameters were classified by factor analysis.The correlations between age,clinical grade and factors were analyzed.Results The correlation coefficient between clinical grade in comparison to subject's age was 0.818.The parameters getting from non contact measurement were obviously correlated with age and clinical grade except SEr and SEsc;the correlation coefficients between parameters and age were-0.601 to 0.605;the correlation cofficients between parameters and clinical grade were-0.630 to 0.570.The non-contact measurement parameters could be classified into two factors;one represented wrinkle depth and roughness;the other represented wrinkle width and counts.These two factors were also obviously correlated with age and clinical grade.Conclusions Clinical grade and non contact measurement methods are both applicable in evaluation of underneath eye wrinkles.The parameters getting from two methods are obviously correlated with each other.

Objective:Patent is one of the most common carriers of medical research innovation. The development of translational medicine is the general trend. It is necessary to explore patent transformation using multiple transactions in public hospitals. This study focused on whether it is appropriate for public hospitals to transfer scientific achievements by equity valuation.Methods:To study the transformation of scientific achievements of state-owned intangible assets in China, summarize the common transaction methods of scientific achievements in colleges, universities as well as scientific research institutions according to literature review and policy analysis, combined with the state-owned hospital’s asset management measures.Results:Through comparative analysis of the differences among public hospitals, universities and scientific research institutions, taking into consideration of the regulations on intangible assets management of hospitals, it is confirmed that public hospitals are not suitable for the transformation of scientific achievements by the way of equity pricing in current. However, other patent transfer and patent license methods are feasible, which can effectively promote the development of translational medicine alternatively.Conclusions:In view of the particularity of public hospitals, public hospitals need to explore multiple transactions to suit for the transformation of hospital patents. Although the current stage of equity pricing transfer does not conform to the asset management regulations of public hospitals, there are other ways to choose at this stage.

Objective:At present, there are several modes of patent transformation of hospital service invention in our country. However, most of them are one-to-one style which is time-consuming and difficult to achieve industrialization in a short time. This study focuses on whether it is appropriate for public hospitals to use the mode of general license (i.e. one patent licensed to several enterprises concurrently or successively) to turn the patents of invention into productivity more efficiently.Methods:Combined with the period of COVID-19 pandemic, Zhongshan Hospital Fudan University successfully applied the mode of general license to achieve the patent transfer experience, and discussed the important value of the mode of general license for translational medicine.Results:The latest achievements of medical research are turned into clinical medical technologies and products quickly and effectively, proposing an appropriate scheme for the rapid transformation of patents, which balanced the interest of different stakeholders to gain the win-win situation.Conclusions:The innovative general licensing model can enable the patents transformation quickly and efficiently as long as it′s used properly.

Objective To estimate the differences between face and hand skin and age correlation in females aged 23-46 years living in Shanghai.Methods 139 women aged 23-46 years from Shanghai attended this program.The water content,pH,TEWL and elasticity of cheek,forehead,hand back of and palm were evaluated by non-invasive skin test instruments.Results The skin water content of these four parts from high to low were forehead,cheek,hand back and palm,and they were different from each other significantly.The pH of cheek was the highest,and forehead was the lowest;there was no significant difference between hand back and palm.TEWL of palm was the high-est,and cheek was the lowest;the difference between forehead and hand back was inconsistent in different age groups.The elasticity of cheek was the highest.There was no significant difference in R2 between forehead,hand back and cheek.The condition of R5 and R7 was different between younger group and older group.In young group the cheek was the highest,and palm was the lowest.In older group,cheek and forehead,palm and hand back began to converge.In addition to the elasticity of cheek and hand back,other parameters of other parts had no significantly difference between different age groups,and also had no significant correlation.Conclusions The cheek has the best skin barrier,elasticity and the highest pH,and the elasticity of cheek decreases with age.The forehead has the highest water content and lowest pH,TEWL and the elasticity of hand back are close to the forehead,and the elasticity of hand back decreases with age.The palm has the highest TEWL and lowest water content.Its total recovery amount in the elastic curve is higher,but the elastic ratio in the recovery is the lowest.