ObjectiveOur study seeks to investigate the connection between systemic immune inflammatory index and renal function， as well as to assess its predictive capacity for the deterioration of renal function in chronic kidney disease patients with non-dialysis. MethodsAdult non-dialyzing patients diagnosed with CKD were included. The computation of SII was calculated as the product of the peripheral blood neutrophil count （×10⁹/L） and platelet count （×10⁹/L）， divided by the lymphocyte count （×10⁹/L）. The logistic and Cox regression models were employed to scrutinize the linkage between SII levels and CKD. ResultsOut of the cohort， a significant portion of patients， numbering 244， which constitutes 17.2%， experienced progression of CKD. A notable upsurge in SII corresponded with an increased prevalence of advanced CKD and its progression， with significant difference. This trend was mirrored by a decline in the estimated glomerular filtration rate and hemoglobin levels， while serum creatinine， C-reactive protein， and lipoprotein（a） levels were on the rise. After adjusting for multiple variables， the natural logarithm of SII exhibited an independent association with advanced CKD ［OR=1.85 95% CI（1.46，2.35），P＜0.01］. Furthermore， Cox proportional hazards model analysis revealed that SII acted as an independent predictor for CKD progression ［adjusted HR= 1.35， 95% CI（1.09，1.67）， P＜ 0.01］. Subgroup analysis indicated a significant interaction among SII， gender， and hypertension concerning CKD progression. ConclusionOur findings underscore the robust relationship between SII and renal function， positioning SII as a potential forecaster for the progression of CKD.

[Objective] The retrospective study was designed to analyze the dynamic relationship between the Apolipoprotein A 1,B100 and the progression of coronary artery lesion.[Methods] Patients who underwent the second coronary angiography or coronary 320-slice CTA at a minimum review interval of 6 months after their first examinations in the Third Affiliated Hospital of Sun Yat-sen University from 2010 to 2015 (n =245),were divided into non progress group (n =114) and progress group (n =131).We compared the differences of clinical and Biochemical data between two groups,and tried to find out the relationship by Logistic Regression analysis.[Results] The baseline levels of APOA1 (1.33 ± 0.29 vs 1.24 ± 0.25,P =0.015),APOA1/AOPB100(1.56 ± 0.65 vs 1.38 ± 0.44,P =0.014)in non progress group were higher than those in progress group.The baseline levels of APOB 100 were similar in both groups.The follow-up levels of APOA1 were higher than the baseline levels in both groups,the variation was significant in progress group (1.24 -± 0.25 vs 1.31 ± 0.28,P =0.006).The levels of APOA1 and APOA1/APOB100 were correlated with progression of coronary artery lesion negatively in single-variate logistic regression analysis.The level of APOA 1 (OR =0.245,P =0.005) was correlated with progression of coronary artery lesion negatively in multivariate logistic regression analysis.[Conclusions] APOA1 may has the effect of delaying the progression of coronary artery lesion,and may predict the progression of coronary artery lesion.