Objective To study the effect o f levamisole against the invasion of Schistosoma japonicum cercariae. Methods Mice infected wit h Schistosoma cercariae were administered orally with levamisole hydrochloride or alkali levamisole two days before the infectio n at a dose of 26.25 mg/kg for 7 days. The liniments of levamisole hydrochlorid e and alkali levamisole were embrocated on the mouse skin two days, one day and 0 day before the infection respectively, and the concentrations of the drug were 1%, 2%, 3%, 5% and 7% respectively. The experimental animals were dissected 4 we eks after the treatment and adult worms were collected. Results The worm reduction rates of mice administered orally with leva misole hydrochloride or alkali levamisole were both 0. The worm reduction rates were both 100% when the mice were embrocated with 5% levamisole hydrochloride on the infection day or with 7% levamisole hydrochloride one day before the infect ion. The worm reduction rates were all 100% when the mice were embrocated with 2 %, 3% or 5% alkali levamisole one day before the infection. Conc lusions Levamisole liniments can prevent from S . japonicum cercaria infection, and alkali levamisole is better th an levamisole hydrochloride. When levamisole is given orally, no effect was show n.

ObjectiveTo observe the effe ct of varnish“Fangyouling” preventing skin invasion from Schist osoma cercariae. MethodsThe“Fangyouling” was made from niclo s amide and permeable improver, and the concentration of the drug was 1%-2%. Exper imenta l mice and rabbits were spread with “Fangyouling” on the abdomen skin without h air at day 1,2,3,4,5,6,7 respectively before infection, compaired with cont rol group. ResultsThe worm reduction rates of mice which were spread with drug 1-4 days and 5-7 days before infection were 100 % and 99 7%-88 1%. The worm reduction rates of rabbits which were spread with dr ug 3-7 days before infection were 86 4%-80 1%. ConclusionThe“Fangyouling” has long efficiency on preventing Schistosoma cercariae from invading skin.

To explore target blood pressure (BP) for lower incidence rate of stroke and better prognosis in patients with H‐type hypertension .Methods :A total of 600 patients with H‐type hypertension according to BP were divided into low level group (＜ 120／90mmHg or DBP ＜ 90mmHg , n ＝ 200 ) , medium level group (120 ～ 130／90mmHg or DBP＜90mmHg ,n＝ 200 ) and high level group (130～140／90mmHg or DBP＜ 90mmHg ,n＝ 200 ) , three groups were treated for two years .Levels of BP ,serum homocysteine (Hcy) ,carotid intima‐media thickness (CIMT) were measured and compared among three groups before and after treatment ,and incidence rates of ad‐verse events were recorded in three groups during follow‐up .Results :During follow‐up ,there were gradual signifi‐cant reductions in serum Hcy level and CIMT in three groups ,P＜0.05 or ＜0. 01. After four‐week follow‐up ,com‐pared with low level group ,there were significant rise in levels of BP and Hcy in medium and high level group ,and SBP of high level group was significantly higher than that of medium level group ,CIMT was significantly higher than the other two groups , P＝0.001 all ;after eight‐week and two‐year follow‐up ,compared with low level group , there were significant rise in levels of BP ,Hcy and CIMT in medium and high level group ,SBP and CIMT of high level group were significantly higher than those of medium level group ;and Hcy level of medium level group was sig‐nificantly higher than that of high level group after two‐year follow‐up , P＜0.05 or ＜0.01. After two‐year follow‐up ,recurrence rate of stroke ,incidence rates of cardiovascular diseases and adverse reactions in high level group were significantly higher than those of low and medium level group ,and recurrence rate of stroke in medium level group was significantly lower than that of low level group , P＜0.05 or ＜0.01. Conclusion :Total therapeutic effect of low level group is significantly better than those of medium and high level group .It can more significantly reduce Hcy level ,further reduce recurrence rate of stroke and mortality and more comprehensively control risk factors of cardiovascular diseases .

Objective To investigate the changes of serum corticosterone and inflammatory factors in rats with different burn degrees. Methods One hundred and fifty male healthy Wistar rats were randomly divided into normal control group, moderate and severe burn hormone treatment groups, and moderate and severe burn physiological saline treatment groups, each group with 30 rats. After anesthesia, the rat models with burn Ⅱ,Ⅲ degrees of 30% back surface area were replicated; the burn, fluid infusion and steroid therapy were not carried out in the normal control group. After modeling, the moderate and severe burn hormone treatment groups were given intra-abdominal cavity injection of hydrocortisone 200 mg/d; while in the moderate and severe burn normal saline treatment groups, normal saline 4 mL·kg-1·d-1 was injected into the abdominal cavity. The dynamic changes of serum corticosterone, tumor necrosis factor-α(TNF-α), and interleukin-6 (IL-6) levels were detected at 1, 4, 12 hours and 1, 3 and 7 days after burn injury in each group. Results The levels of serum corticosterone at different time points after moderate and severe burn injury treatment were higher than those in normal control group, the degree of increase at 4 hours after injury in severe burn saline treatment group was more significant than that in moderate and severe burn hormone treatment groups and moderate burn saline treatment group (ng/L: 200.45±2.63 vs. 110.56±9.23, 146.02±3.28, 160.02±8.22). Except the level at 1 hour after injury in the moderate and severe burn hormone treatment groups, the TNF-αlevels in all the other groups at different time points were significantly higher than those in the normal control group (all P < 0.05); the IL-6 levels in various treatment groups were all higher than the IL-6 level in the normal control group, moreover, the increase degree on 1 day after injury in the severe burn saline treatment group was more obvious than the degrees in the moderate and severe burn hormone treatment groups and the moderate burn saline treatment group [TNF-α(ng/L): 39.78±4.30 vs. 15.99±1.40, 20.58±2.10, 25.98±1.60, IL-6(ng/L): 210.20±6.70 vs. 125.45±3.10, 149.81±4.20, 161.40±3.80, all P < 0.05]. Conclusion The burn stress may lead to the significant increase of serum corticosterone level in rats, and the stress dose of hydrocortisone has a certain regulatory effect on serum corticosterone and inflammatory factors in rats after different degrees of burn.