Objective To investigate the risk factors of pregnancy-induced hypertension (PIH) in Zhoushan Area. Methods A total of 55 PIH patients who were treated in Zhoushan Women and Children Hospital from January 2010 to December 2012 were enrolled as the PIH group, and another 55 pregnant women without PIH were set as the control group. The serum calcium(Ca2+), phosphorus(P3+), total cesterol(TC), and triglyceride(TG) were detected by biochemical analyzer. Univariate and multivariate analyses were performed to reveal the potential correlations between these biochemical indicators and PIH. Results The serum levels of Ca2+, P3+, and TC between PIH group and control group were significantly different (P<0.01 or P<0.05), while the TG showed no significant difference between these two groups (P=0.15). Multivariate Logistic regression analysis showed that serum P3+and TC were risk factors for PIH (P<0.01 or P<0.05) whereas serum Ca2+was a protective factor (P<0.01). Conclusion Serum Ca2+, P3+and TC levels can be used for monitoring PIH in the islands.