Background Monocyte chemoattractant protein-1 (MCP-1) polymorphisms are demonstrated to be significantly associated with the susceptibility to uveitis in recent years,while a consistent conclusion for the association of MCP-1-2518A/G polymorphism and uveitis risk is not reached yet.Objective This study was to comprehensively investigate the correlation between MCP-1-2518A/G polymorphism and uveitis susceptibility.Methods General searches of electronic database including PubMed,Embase,Web of Science,CNKI,VIP,Wanfang database and China biomedical literature database (CBD) were performed to retrieve published case-control studies regarding the association between MCP-1-2518A/G polymorphism and uveitis risk.The data were screened according to the inclusion and exclusion criteria and extracted,and the quality of included studies was evaluated.The pooled odds ratios (OR) with 95％ confidence intervals (CI) were calculated.Publication bias and sensitivity analysis were also assessed.All statistical analyses were conducted with RevMan 5.2 and Stata 12.0 software.Results A total of 8 eligible case-control studies involving 1 197 cases and 1 570 controls were included in the Meta-analysis.The results showed no significant association of MCP-1-2518A/G polymorphism with uveitis susceptibility in the G vs.A,GG vs.AA and GG vs.AG+AA models (all at P＞0.05).MCP-1-2518A/G polymorphism was found to be significantly associated with uveitis risk in the GG+AG vs.AA model (P =0.01,OR =1.25,95％ CI:1.06-1.48),while no significant association was found by the sensitive analysis (GG + AG vs.AA:P =0.19,OR =1.16,95％ CI:0.93-1.45).The subgroup analysis by uveitis types revealed that the individuals carrying allele-G or GG genotype harbored a significantly increased risk for anterior uveitis (G vs.A:P=0.01,OR=1.49,95％ CI:1.16-1.90;GG vs.AA:P=0.01,OR=2.09,95％ CI:1.21-3.61;GG+AG vs.AA:P=0.01,OR=1.58,95％ CI:1.12-2.23;GG vs.AG+AA:P=0.01,OR=1.78,95％ CI:1.12-2.83).The individuals with GG+AG vs.AA genotype harbored a significantly increased risk for Behcet's disease (BD) (P=0.04,OR =1.35,95％ CI:1.01-1.79) but not for other types of uveitis (P ＞ 0.05).Additionally,a significantly elevated risk was found in uveitis patients with allele-G or GG genotype in Asian population in the subgroup analysis based on ethnicity (G vs.A:P =0.04,OR =1.15,95％ CI:1.01-1.32;GG vs.AA:P=0.04,OR=1.32,95％ CI:1.02-1.71;GG+AG vs.AA:P=0.01,OR =1.36,95％ CI:1.09-1.70),but that was not found in Caucasians population (all at P＞0.05).Conclusions MCP-1-2518A/G polymorphism is significantly associated with the risk of uveitis in Asian population,anterior uveitis and BD.The allele-G or GG genotype may increase the risk of uveitis in Asian population,anterior uveitis and BD.

AIM: To investigate the efficacy of modified silicone oil removal combined with scleral buckling in the treatment of patients with retinal detachment under silicone oil tamponade.METHODS:The retrospective study included a total of 14 patients(14 eyes)who underwent treatment for retinal detachment with silicone oil tamponade at our hospital between January 2021 and February 2023. The modified silicon oil extraction combined with scleral buckling procedure was employed. A self-made 23-gauge suction device was applied in the silicon oil extraction, which involved removing the needle from a disposable blood transfusion set, trimming it to 2.5-3.0 mm near the beveled end, and connecting the other end to a 10 mL syringe without the plunger. The opposite end of the syringe was connected to the negative pressure system of the vitreous cutter to accomplish the silicon oil removal. Scleral compression blocks in scleral buckling surgery using a homemade composite device. No additional silicon oil was injected after the procedure. Follow-up was conducted for 6 mo, assessing retinal reattachment, best-corrected visual acuity(BCVA), intraocular pressure, and complications.RESULTS: At the 6 mo follow-up, the retina was completely reset in 13 eyes, with a retinal reset rate of 93%, and an improvement in BCVA(LogMAR)compared with the preoperative period(0.95±0.18 vs 1.15±0.21, P=0.002). Transient high IOP occurred in 6 eyes at 1 d postoperatively and returned to normal after medication control. There were no intraoperative complications such as retinal hemorrhage, retinal incarceration, or iatrogenic retinal breaks, and no postoperative complications such as endophthalmitis or choroidal detachment.CONCLUSIONS:Modified silicone oil removal combined with scleral buckling can effectively treat retinal detachment in the silicone oil tamponade and induce retinal reattachment.