Objective　To investigate the causes of recurrent spontaneous abortion(RSA) and to know the relation between RSA and antiphospholipid thrombosis syndrome(APL-T). Methods　ELISA and PTT-LA were used to detect anticardiolipin antibody(ACA) and lupus anticoagulant(LA) in 32 patients with RSA and 20 normal controls(NC). Results　There were 17 positive of antiphospholipid antibody(APA) in RSA group. The incidence was significantly higher than that in NC group. The incidence of LA was also significantly higher than that in NC group. 8 patients were diagnosed as APL-T. Conclusion　LA may be the more important reason of RSA. It should be considered as APL-T when RSA is unexplained.

Dental Implantation, Endosseous ; Dental Implants, Single-Tooth ; Humans ; Maxilla ; surgery

Dental Implants ; Dental Prosthesis Design ; trends ; Humans

Objective: To view the characteristics and the primary treatment of civilian firearm wound in the maxillofacial region.Methods: 301 cases of the casualties admitted to our hospital were retrospectively investigated,the epidemic, etiology, wound characteristics, and treatments of the patients were viewed respectively. Results: Of all the cases, the ratio of male to female was 5.1∶1.0. 57% of the injuries were caused by gunshot, 66% were with multiple injuries.16% combination wound were craniocerebral injuries. In this group of patients, more than 900 wound tracks were found, 72% of the tracks were nonpenetrating and 67% of those were with foreign bodies lodged in. Burns with blast injuries were the main complex wounds, which mostly occurred in explosion. The treatments mainly included life maintaining, earlier debridement and infection control. Conclusions: The maxillofacial firearm injuries are complex and have their own characteristics depending on the firearms, the wound styles and the regional anatomy. All the factors must be considered when treatment is given.

Granzyme B is an important effect factor of cytotoxic T lymphocytes in the immune killer function,can quickly induce cell apoptosis of the target cell.It is complicated for the reasons and the ways of the occurrence of the cell apoptosis,many genes are involved in gene regulation of cell apoptosis,and the B-cell lymphoma/leukemia-2 gene family members play a crucial role in the process of cell apoptosis.This paper mainly reviews the correlation of GrB and Bcl-2,Bid with cell apoptosis.

Interleukin-10 (IL-10) is an immuno-regulatory cytokine,which is well known for its immunosuppressive function.IL-1O can act on a variety of immune cell subsets and play an immunosuppressive effect through a variety of ways.It plays an important role in the tumor immune escape.Recent studies show that IL-10 also has an immune-stimulating function,which is presumably a pluripotent cytokine.This paper will combine the latest literature to summary the positive and negative regulatory roles of IL-10,mediation ways in the tumor and the relationships with prognosis.

Tear fluid is a complex body fluid,which may contain thousands of protein/peptides and other molecules.Studies have determined that the changes in the chemical compositions of tears play an important role in some diseases and their progression.Tear fluid is a useful and easily accessible source for understanding ocular surface diseases,other eye diseases,and systemic diseases.It can also be used for identification of biomarkers for clinical applications and pharmaceutical development.Therefore,quantitative proteomic analysis of tears may provide very important information for diagnosis and treatment of eye diseases or the development of new drugs.Knowledge of the current proteomic technologies for tear analysis is helpful for conducting studies.In addition,ophthalmologists should pay close attentions to the association between tear proteomic changes and eye diseases,recent advances in tear proteomics and their applications in studying ocular surface diseases and conditions.

Previous research demonstrated that human tear is a valuable source for biomarker discovery for many ocular surface diseases.Here, we systematically summarized the changes of tear protein profile in many ocular surface diseases, including dry eye, blepharitis, ocular allergy, keratoconus, infectious keratitis, conjunctivochalasis, ocular rosacea, and thyroid-associated ophthalmopathy and other conditions, such as diabetes, ocular surface wounding and refractive surgeries, contact lens wearing, and effects of glaucoma medication on ocular surface, attempting to make ophthalmologists understand the specific changes of tear protein profile in each disease or condition and hold the promise for optimal management of the diseases.

Objective To investigate the clinical value of 64 slice spiral CT low dose chest scan in the diagnosis of pulmonary tuberculosis.Methods From January 2015 to January 2016,45 patients with suspected pulmonary tuberculosis were studied.All patients underwent routine chest CT scan and low dose chest CT scan.To compare the difference of radiation dose related parameters between normal dose chest CT scanning and low dose chest CT scan.To observe the display of the characteristics of lung disease by routine dose chest CT scanning and low dose chest CT scan.Results In 45 patients,there were a total of 30 patients were diagnosed with tuberculosis.The diagnostic sensitivity,specificity and diagnostic coincidence rate of conventional CT scan and spiral CT low-dose scan were 93.3% and 86.7% respectively.In low dose CT scanning radiation dose related parameters,the effective dose [(1.36±0.22)mSv vs.(5.24±0.68) mSv],CT dose index[(31.8±3.7) vs.(51.2±6.3)] and dose length product[(35.4±5.4)mGycm vs.(137.9±26.1) mGycm]were significantly lower than those of the conventional dose CT scan,the differences were statistically significant (all P<0.05).Conventional dose and low dose CT scan could show the lung lesions of pulmonary tuberculosis.Comparison between the two groups,low dose CT scanning on the burr sign and grinding glass shadow display rate was low.Compared with the conventional dose CT scanning,the difference was statistically significant (P<0.05).Conclusion In the diagnosis of pulmonary tuberculosis,the radiation dose of 64 slice spiral CT is significantly decreased,be able to clear most of the lung lesions.However,the effect is poor in the display of the grinding glass and the thin and short burr.

Objective To discuss which is more efficient between Needle-knife precut and Plough-knife precut in difficult biliary cannulation. Methods The difference in the average time of cannula, percentage of cannula achieve-ment and the complication rate between the two kinds of operation were compared. Results The percentage of can-nula achievement about the Needle-knife precut is higher than Plough-knife precut, while there is no notable differ-ence in average time of cannula and the complication rate between the two precuts. Conclusion Needle-knife precut is more efficient than Plough-knife precut in difficult biliary cannulation, if guide wire can not get into pancreatic duct.