Both DNA methylation and microRNAs(miRNA)play important roles in the development and progression of human cancer. Recently, it has been demonstrated that the promoter of miRNA can be methylated and DNA methylation can be regulated by miRNA through DNA methyltransferase. Research targeting this reciprocal regulatory mechanism may shed some light on the diagnosis and treatment of cancer.

Humans ; Pre-Exposure Prophylaxis ; methods ; Rhinitis, Allergic, Seasonal ; drug therapy ; Seasons

China ; Humans ; Practice Guidelines as Topic ; Rhinitis, Allergic ; diagnosis ; therapy

Child ; Glucocorticoids ; therapeutic use ; Histamine Antagonists ; therapeutic use ; Humans ; Rhinitis, Allergic, Perennial ; drug therapy

Child ; Desensitization, Immunologic ; Humans ; Rhinitis, Allergic ; Rhinitis, Allergic, Perennial ; therapy

AIM　to compare the bioavailability and pharmacokinetics of two acyclovir tablets. METHODS　Concentrations of acyclovir in 10 men serum after po 600 mg of two acyclovir tablets were determined , in random 2-way crossover design. Pharmacokinetic parameters were also estimated. RESULTS　The peak concentrations of test and reference tablets were 1.24±0.49 and 1.17±0.20 μg/ml, the AUC 7.56±1.80 and 7.56±2.10μg*h/ml, respectively. The relative bioavailability was 101.36%±11.62%. The test formulation was found bioequivalent to the reference in AUC and Cmax by two one-side t test. CONCLUSION　Two tablets were bioequivalent.

OBJECTIVE:To prepare Lipoic acid orally disintegrating tablets,and to evaluate its quality. METHODS:Lipoic acid orally disintegrating tablets were prepared with direct compression after wet granulation. With disintegration time and dissolu-tion as index,the constituents of disintegrating agent,filler and lubricant were screened by single factor test combined with orthogo-nal test. The tablet weight,hardness,disintegration time,accumulative rate and percentage content were investigated. RESULTS:The optimal formulation was MCC 167.58 mg,L-HPC 23.94 mg,PVPP 47.88 mg,mannitol 60 mg,lipoic acid 300 mg and mag-nesium stearate 0.6 mg. The parameters of prepared disintegrating tablets was as follows as (0.59 ± 0.05) g in weight,(20.32 ± 0.16)kg in solidity and(23.5±0.4)s in disintegration time,101.49% in 3 min accumulative dissolution rate,96.34% of labeled content. CONCLUSIONS:Lipoic acid orally disintegrating tablets are prepared successfully and controllable in quality.

ObjectivesTo observe correlation between serum vitamin A status and prevalence or severity of NRDS. MethodsRecruited into this study were 166 preterm infants admitted to our neonatal department. The serum concentration of vitamin A was measured, and the prevalence of NRDS at different levels of vitamin A was compared. According to the clinical manifestation and X-rays, there were 30 infants diagnosed as NRDS. Another 30 patients from the rest 133 infants without NRDS were randomly selected as control group according to the gestational ages, then the difference between NRDS group and control group were observed according to gestational ages. The 30 preterm infants with NRDS were divided further into mild group (in-cluding stagesⅠandⅡ,n=18) and severe group (including stageⅢ andⅣ,n=12) according to ifndings chest X-ray, then the difference between these two groups were observed.ResultsIn the 166 preterm infants recruited, 65/166 had serum vitamin A lower than 0.35 μmol/L, in which 14/65 (21.54%) were NRDS patients. Another 93/166 patients had serum vitamin A ranged from 0.35 μmol/L to 0.7 μmol/L, in which 15/93 (16.13%) were NRDS patient. The rest 8/166 had serum vitamin A higher than 0.7 μmol/L, in which 1/8 (12.50%) were NRDS patient. However, the differences between each two groups were not signiifcant. When gestational ages ranged from 34 to 37 weeks, the serum concentrations of vitamin A of NRDS group were lower than that in controls (P<0.05). No signiifcant difference between the serum concentrations of vitamin A and the severity of NRDS were ob-served (P>0.05).ConclusionsThe prevalence of NRDS for those preterm infants lacking of vitamin A was tended to increase. And the late preterm infants (34 w≤ GA <37 w) with vitamin A deifciency are prone to NRDS.

Allergy and Immunology ; Asia ; Congresses as Topic ; Humans

Humans ; Rhinitis, Allergic ; Rhinitis, Allergic, Perennial ; diagnosis