Objective To preliminary study clinical efficacy and toxicity of endostatin (ES) combined radiotherapy and chemotherapy in advanced non-small cell lung cancer (NSCLC),and evaluate its effectiveness and safety.Methods We retrospectively reviewed 64 patients with Ⅲ B-Ⅳ stage NSCLC of Harbin Medical University Cancer Hospital from February 2009 to February 2012.The patients were divided into two groups:chemoradiotherapy group,39 patients and ES add chemoradiotherapy group,25 patients.The short-term effect,the total efficiency,median survival time,progression-free survival time and disease-free survival time were compared.Results The total effective rate of chemoradiotherapy group was 76.9％,while the total effective rate of ES add chemotherapy group was 84.0％ (x2 =0.47,P =0.492).Chemoradiotherapy group,compared to ES add chemotherapy group,the median survival time,median progression-free survival time,median disease-free survival time were 11.52 months vs 16.51 months (x2 =3.74,P =0.042),7.32 months vs 10.37 months (x2 =5.32,P =0.025) and 5.21 months vs 7.57 months (x2 =4.56,P =0.035) respectively.The mainly adverse drug reactions were hematologic toxicity and gastrointestinal reactions,but there were no significant differences between the two groups; radiotherapy side effects mainly showed the grade 1 to 2 radiationinduced lung injury and radiation esophagitis (chemotherapy group had one case of grade 3 radiation-induced lung injury),but also had no significant differences between the two groups.Conclusion ES combined chemoradiotherapy can achieve a better short-term clinical efficacy without increasing adverse effects of radiotherapy or chemotherapy in advanced non-small cell lung cancer.

Objective To investigate the relationship between C-reactive protein (CRP) and postoperative cognitive function of female patients underwent cardiopulmonary bypass (CPB) cardiac surgery.Methods Sixty female patients were scheduled for CPB surgery from January 2012 to May 2013,aged form 35 to 60 years,mean aged (47.5 ± 12.5) years,and in state of ASAⅡ ～ Ⅲ.All patients had general anesthesia and CPB cardiac surgery.Blood samples were taken from peripheral vein before induction and 6 days after surgery.The neuropsychology assessment was measured with Wechsler Adult Intelligence Scale RC 2 + 1 (WAIS-RC) and digital span the first day preoperative,the 7th day,and the first month postoperative.The postoperative cognitive dysfunction (POCD) was judged with Newman style.Results (1) The rate of POCD of the 7th day and first month postoperatively was 50％ and 25％,respectively.(2) The Pearsong correlation showed negative correlation between CRP preoperative at the 6th day and the 7th day,and the first month postoperative WAIS-RC score(P ＜ 0.05).(3) The Pearson's figure showed negative correlation between CRP at the 6th day postoperative with digital span (P ＜ 0.05).Conclusions The ratio of POCD after CPB surgery was higher.It is instructively significant to monitor the variations of concentration of serum CRP for the selection of cognitive impairment in patients with cardiac-pulmonary bypass surgery.

Epidemiological and clinical studies have provided compelling evidence that suggests a link between the relative lack of infectious diseases and the increase in allergic disorders. Asthma usually starts early in life. The early occurrence of asthma suggests that prinatal influences are of importance.Prenatal or postnatal exposure to endotoxins and other bacterial products may protect against the development of asthma in the infant. We will briefly outline the current state of the relationship of the perinatal infection and asthma in the infant, and focus our review mainly on possible rneehanism of perinatal infection providing protection against asthma in the infant, such as Th1/Th2 immune system, transcription factors, protection by maternal antibodies, endotoxin tolerance, pulmonary inflammation and genetic influences.

The antimicrobial abuse has become an indisputable fact as well as a global public health concern.At the 2016 G20 summit in Hangzhou,the issue of antimicrobial resistance was also put on the agenda of world leaders.This paper analyzed the status quo of global antimicrobial resistance.With reference to the report Tackling drug-resistant infections globally: final report and recommendation written by British Lord Jim O′Nell published in May 2016,the main influencing factors of antimicrobial resistance were described.In addition,this paper proposed countermeasures for antimicrobial resistance,including carrying out large-scale promotional activities,improving global public health conditions,reducing antimicrobial use in agriculture,strengthening the global surveillance of antimicrobial resistance,developing new treatment products for infectious diseases,and building a new pattern of global response.

Elaborated in this paper are the design and layout of library physical spaces ( including public space , collection space , reading space , popular science and academic exchange space , historical and cultural space , characteristic collection space) and library virtual spaces (including information commons, virtual research space, individualized digital space ) , which will be expanded with the increasing needs of users in digital environment .

Articles, reviews and proceeding papers published from 2012 to 2015 in medical, chemical and physical journals with the highest IF were retrieved from 2014 JCR and analyzed using the BICOMB software to generate the co-occurrence matrix of authors and plot the map of co-authorship network in medical, chemical and physical fields using the UCINET software.The correlation between the parameters for assessing the importance of co-au-thorship network nodes ( degree centrality, betweenness centrality, closeness centrality, eigenvector centrality) and biblimetric parameters of authors ( number of published papers, frequency of cited papers) was analyzed using the SPSS, which showed that degree centrality, betweenness centrality, and eigenvector centrality were positively corre-lated with the number of published papers and the frequency of cited papers whereas betweenness centrality was negatively correlated the number of published papers and the frequency of cited papers.Betweenness centrality was more significantly correlated with the number of published papers whereas degree centrality was more significantly correlated with the frequency of cited papers.

Objective To investigate the value of nerve conduction velocity detection in early diagnosis of peripheral neuropathy in type 2 diabetes.Methods Motor nerve conduction velocity (MCV)and sensory nerve con-duction velocity (SCV)for 94 patients were detected who was the first time diagnosed type 2 diabetes in our hospital from May 2014 to May 2015.The statistic results of nerve conduction velocity were conducted and then compared with clinical diagnosis to analyze the diagnosis rate for diabetic peripheral neuropathy (DPN).Results The abnormal rate of lower limb nerve conduction velocity was higher in the examined patients,which in the SCV of superficial peroneal nerve was especially highest(69.1%).The diagnostic rate of nerve conduction velocity in DPN was 71.3%,and the clinical diagnosis rate was 33.0%.The difference was statistically significant between the two diagnostic methods (χ2 =8.195,P =0.004).Conclusion Nerve conduction velocity detection has important value for the early diagno-sis of DPN.Patients for the first time diagnosed with type 2 diabetes should be carried out this detection to improve the diagnosis rate of DPN.

OBJECTIVE: To investigate the chemical constituents in the fruits of Cerbera manghas Linn. METHODS: Silica gel column, HPTLC, and Sephadex LH-20 chromatography were applied to isolate the chemical constituents. The structures of the isolated compounds were elucidated by spectroscopic techniques and physicochemical properties. RESULTS: Fifteen compounds were isolated and identified including eleven phenolic acids, i.e., benzoic acid(1), vanillic acid(2), vanillin(3), p-hydroxybenzaldehyde(4), isophthalaldehydic acid(5), β-hydroxygpropiovanillone(6), ficusol(7), evofolin B(8), 3, 4'-dihydroxypropiophenone(9), p-hydroxybenzoic acid(10), protocatechuic acid(11), one monoterpene, i.e., cerbinal(12), two cardiac glycosides, i.e., 17-β-neriifolin(13) and cerberin(14), and one triterpenoid, i.e., ursolic acid(15). CONCLUSION: All the compounds except compound 13 and 14 are obtained from the fruits for the first time. Compound 5 is a new natural product, and compounds 1, 3, 6-9, and 15 are obtained from genus Cerbera for the first time.

Objective To investigate the interactions between melanoma-derived exosomes and the microenvironment.Methods The exosomes were isolated from the culture medium of mouse melanoma cells and then co-cuhured with mesenchymal stromal cells (MSC) after identification.Immunofluorescence assay was performed to observe the exosomes engulfed by MSC.CCK-8 and transwell assays were used to evaluate the proliferation and migration of MSC.Effects of the exosomes on the expression of α-smooth muscle actin (α-SMA) in MSC were analyzed by Western blot.Results Co-culture of MSC with melanoma cell-derived exosomes enhanced the proliferation and migration of MSC as well as the expression of α-SMA.All of the changes mediated by the exosomes could be blocked by using the inhibitor of TGF-β receptor.Conclusion Melanoma cell-derived exosomes enhanced the proliferation and migration of MSC as well as the expression of α-SMA through TGF-β signaling pathway,which provided an advantageous microenvironment for melanoma progression.

Mantle cell lymphoma (MCL),as a kind of highly aggressive non-Hodgkin's lymphoma,is characterized by malignant B cell infiltration of lymph node,gastrointestinal tract and bone marrow.Patients suffering from MCL are prone to drug resistance or progression of disease.The 55th ASH annual meeting about MCL explored all aspects.In preclinical research aspects:new mutations including ATM,POT1 and tumor microenvironment further improved the pathogenesis mechanism of MCL.In prognostic indicators,minimal residual disease detected by molecular techniques and whole genome methylation analysis provided new tools for monitoring MCL prognosis and curative effect to guide further risk stratification and individual treatment.Exploration of high effective and low toxic side effective treatment strategies for elderly MCL patients has become a major focus of the meeting.Chemoimmunotherapy including Lenalidomide,bendamustine,rituximab and autologous stem cell transplantation provide more options for the treatment of elderly MCL patients.Novel drugs such as ibrutinib,ABT-199 and MLN8237 have shown encouraging results in preclinical trials which provide new hope for MCL patients.