3.Reciprocal regulation between DNA methylation and mircoRNA
Journal of International Oncology 2010;37(10):728-731
Both DNA methylation and microRNAs(miRNA)play important roles in the development and progression of human cancer. Recently, it has been demonstrated that the promoter of miRNA can be methylated and DNA methylation can be regulated by miRNA through DNA methyltransferase. Research targeting this reciprocal regulatory mechanism may shed some light on the diagnosis and treatment of cancer.
9.Pharmacokinetics and Relative Bioavailability of Acyclovir Tablets in Men
Journal of China Pharmaceutical University 2001;(3):210-212
AIM to compare the bioavailability and pharmacokinetics of two acyclovir tablets. METHODS Concentrations of acyclovir in 10 men serum after po 600 mg of two acyclovir tablets were determined , in random 2-way crossover design. Pharmacokinetic parameters were also estimated. RESULTS The peak concentrations of test and reference tablets were 1.24±0.49 and 1.17±0.20 μg/ml, the AUC 7.56±1.80 and 7.56±2.10μg*h/ml, respectively. The relative bioavailability was 101.36%±11.62%. The test formulation was found bioequivalent to the reference in AUC and Cmax by two one-side t test. CONCLUSION Two tablets were bioequivalent.