Refractory nephrotic syndrome(RNS) is one of the main causes of end-stage renal disease (ESRD) in children,which is also a difficult issue in clinic.Several therapies,including immunosuppressive agents,have been shown to be effective and safe for RNS.It is proved,however,that a substantial number of children are still refractory to treatment despite these therapies.Recently,rituximab as a new immunosuppressant has achieved good results for RNS,and a number of case reports and clinical trials have suggested that rituximab may be effective for children with RNS.This review will analyse the scientific basis for the efficacy and safety of using rituximab in children with RNS.

Acute kidney injury (AKI)was a common problem in children in clinic.pRIFLE Criteria, AKIN Criteria, KDIGO Criteria are the main classification criteria of AKI.Though serum creatinine is still used as the most common biomarkers for diagnosis of AKI, the sensitivity and specificity is unsatisfactory.In recent years, many potential biomarkers of AKI have been studied in a variety of experimental and clinical settings.This review describes the novel biomarkers of AKI, including cystatin C, neutrophil gelatinase associated lipocalin, interleukin-18 ,kidney injury molecule-1 and liver-type fatty acid binding protein,, which have now made a progress in clinic.

Subclinical hypothyroidism is common in children,but its clinical significance is widely debated.The pathogenesis is not very clear and etiology appears to be multifactorial,such as autoimmune thyroiditis,obesity,antiepileptic drugs and so on.Currently there is no broad consensus on the management of children with subclinical hypothyroidism.In this review,the available evidences regarding to investigation,risk factors,trreatments and outcomes for this disease are summarized.

Acupuncture Points ; Acupuncture Therapy ; Adult ; Aged ; Anti-Anxiety Agents ; therapeutic use ; Anxiety Disorders ; drug therapy ; etiology ; therapy ; Combined Modality Therapy ; Female ; Humans ; Male ; Middle Aged ; Stroke ; complications

Influenza A(H1N1)virus is a re-mixed strains of human influenza virus genes,avian influenza virus gene and swine influenza virus gene.Influenza A(H1N1)pandemic influenza has spread around the world,which has drawn worldwide attention.In order to early discovery,early diagnosis,early treatment and effective prevention of Influenza A(H1N1),we describe the characteristics of linfluenza A(H1N1)virus,epidemiology,pathogenesis,clinical manifestations,laboratory examination and effective treatment and preventive measures.

The Wireless Body Area Network (WBAN) is a key part of the wearable monitoring technologies, which has many communication technologies to choose from, like Bluetooth, ZigBee, Ultra Wideband, and Wireless Human Body Communication (WHBC). As for the WHBC developed in recent years, it is worthy to be further studied. The WHBC has a strong momentum of growth and a natural advantage in the formation of WBAN. In this paper, we first briefly describe the technical background of WHBC, then introduce theoretical model of human-channel communication and digital transmission machine based on human channel. And finally we analyze various of the interference of the WHBC and show the AFH (Adaptive Frequency Hopping) technology which can effectively deal with the interference.
Computer Communication Networks ; Humans ; Models, Theoretical ; Wireless Technology

Objective The study was designed to investigate the effect of atomization inhalation of Qingjin-Huatandecoction on prevention of elderly patients’ postoperative pulmonary complications after thoracotomy.MethodsA total of 60 elderly patients with thoracotomy were randomized into 2 groups. Both groups of patients were treated with oxygen uptake, anti-infection, antispasmodic, analgesic, and nutritional support. Based on the conventional treatment, the control group was added with atomization inhalation of mucosolvan and dexamethasone, while the treatment group with atomization inhalation ofQingjin-Huatan decoction. The volume of phlegm, serum CRP, TNF-α level and absolute neutrophil count (ANC), arterial blood gasanalysis, and records of the pulmonary complications were meausred.Results The pH value at Day 3 (7.39 ± 0.06vs. 7.36 ± 0.05,t=2.120), the PaO2at Day 3 (86.51 ± 3.96 mmHgvs. 84.07 ± 3.51 mmHg,t=2.520) and Day 5 (92.27 ± 2.94 mmHgvs. 90.40 ± 3.08 mmHg,t=2.400) of treatment group were significantly higher than those of the control group; the PaCO2at Day 3 (44.57 ± 2.53 mmHgvs. 46.39 ± 3.35 mmHg,t=2.390) and  Day 5 (40.77 ± 2.48 mmHgvs. 42.42 ± 3.33 mmHg,t=2.130) of treatment group were significantly lower than those of the control group. The serum CRP at Day 3(8.26 ± 2.38 mg/Lvs. 9.76 ± 2.37 mg/L,t=2.440) and Day 5 (6.94 ± 1.76 mg/Lvs. 8.15 ± 2.38 mg/L,t=2.250), the ANC at Day 3 (8.54 ± 1.85)×109/Lvs. (9.58 ± 1.94)×109/L, t=2.140) and Day 5 (6.54 ± 1.85)×109/Lvs. (7.58 ± 1.95)×109/L,t=2.160), the serum TNF-a at Day 5 (7.54 ± 1.38 mg/Lvs. 8.43 ± 1.36 mg/L,t=2.540) of treatment group were significantly lower than those of the control group. The sputum volume at Day 3 (50.74 ± 18.46 ml/dvs. 59.92 ± 15.25 ml/d,t=2.099) and Day 5 (39.64 ± 18.21 ml/dvs. 48.99 ± 13.55 ml/d,t=2.256) of treatment group was lower than that of the control group. At Day 5, the pneumonia (3.33%vs. 20.00%,t=4.043) and the atelectasis (6.67%vs. 26.77%,t=4.320) of treatment group were significantly lower than those of the control group(P<0.05).ConclusionAtomization inhalation ofQingjin-Huatandecoction can improve pulmonary function of postoperative pulmonary complications of elderly patients after thoracotomy, take control of inflammation and the occurrence of postoperative pulmonary complications.

Objective To study the treatment influences on immunity and tumor recurrence of oral canc -er patients with the combination therapy of hyperbaric oxygen treatment and postoperative adjuvant chemotherapy . Methods In the period from March 2011 to March 2014 ,84 patients were clearly diagnosed with oral cancer and randomly divided into hyperbaric oxygen treatment combined postoperative adjuvant chemotherapy group ( group A,n=42)and postoperative adjuvant chemotherapy group (group B,n=42).From day 1 prior to the last day of chemotherapy ,patients in group A were treated with hyperbaric oxygen ,and patients in group B were just accepted chemotherapy.After chemotherapy,we tested the levels of CD3 +,CD4 +,CD8 +and NK cells by flow cytometry, and the expression of IL -2,IL-4,IL-10 and INF-γby ELISA essay.All patients had been followed for two years.Results The levels of CD4 +and NK cells in group A were higher than group B (P<0.05),but the levels of CD3 +and CD8 +between the two groups were obviously different (P>0.05).Compared with group B,the ratio of CD4 +and CD8 +was increased in group A(P<0.05).The levels of cytokines involved IL -2,IL-4,IL-10 and INF-γin group A were higher than the levels of group B ( P<0 .05 ) .Follow-up results showed that pa-tients treated with hyperbaric oxygen combined postoperative adjuvant chemotherapy had less recurrence in 2 years(P<0.05).Conclusion Hyperbaric oxygen combined postoperative adjuvant chemotherapy can improve the patients′immune function ,and to be effective in preventing two years′recurrence .

OBJECTIVE:To improve the quality standard of Naoliqing capsule. METHODS: The Sus scrofa domestica and Achyranthes bidentata in Naoliqing capsule were identified by TLC, and the content of oleanolic acid was determined by HPLC. RESULTS: The characteristic TLC spots of the Sus scrofa domestica and Achyranthes bidentata in Naoliqing capsule were detected. The linear range of oleanolic acid was 0.5～7.5 ?g(r=0.999 6) with an average recovery of 97.43%(RSD=1.94%,n=6). CONCLUSION: The results are conducive to the improvement of the quality standard of Naoliqing capsule.

OBJECTIVE:To observe the efficacy of Compound Epidermal Growth Factor Pellicles for recurrent oral ulcer. METHODS: 106 patients with recurrent oral ulcer were randomly assigned to receive Compound Epidermal Growth Factor Pellicles with efficacy-confirmed hospital preparation as control. The clinical efficacy in two groups was compared. RESULTS: The effective rate was significantly higher in patients treated with Compound Epidermal Growth Factor Pellicles than with hospital preparation (control) (89.66% vs. 75.00%,P