Objective To explore the effect of nursing intervention on rehabilitation of stroke patients with hemiplegia.Methods 60 cases of hemiplegic patients after stroke were divided into the control group and the experimental group with 30 cases in each group randomly.The rehabilitation status was evaluated and compared using self rating depression scale (SDS) and activities of daily living (ADL) scale before and after intervention.Results After nursing intervention,ADL score and SDS score were better,treatment effect was also better,but SDS total score showed no significant difference.Conclusions Nursing intervention can effectively reduce or eliminate depression of patients after stroke,strengthen subjective initiative of patients,so that patients can actively cooperate with the treatment,and promote disease rehabilitation.