No abstract available.
Diagnosis* ; Prostate* ; Prostatic Neoplasms* ; Ultrasonography*

PURPOSE: To assess the locoregional recurrence rate, survival rate and prognostic factors after modified radical mastectomy and postoperative adjuvant radiation therapy with or with chemotherapy in high-risk breast cancer patients. METHODS: Between 1984-1995, 48 patients underwent postoperative irradiation to the regional lymphatics and chest wall due to large tumor size (> or = 5 cm) or small tumor size (<5 cm) with axillary lymph node involvement after modified radical mastectomy. The median age of the patients was 47 years (range, 31-79 years). The clinical tumor size was <2 cm in 1 patient, 2-5 cm in 15 patients, and >5 cm in 32 patients. Thirty two patients had positive axillary lymph nodes. Forty two patients were irradiated to the chest wall and regional lymph node and 6 patients were irradiated in the chest wall only. Radiation dose to the chest wall and regional lymph node was 5040 cGy/28 fraction. The median follow-up time was 61 months. RESULTS: Locoregional recurrence rate was 8% and distant metastatic rate was 14%. The actuarial overall survival rate and disease-free survival rate was 63% and 62% at 5 years, respectively. The median survival time was 67 months. Five-year overall survival rate by the stage is 70% in IIB and 58% in IIIA. The significant prognostic factor for survival on multivariate analysis was the stage. CONCLUSION: Postoperative adjuvant radiation therapy in high-risk breast cancer can reduce the locoregional recurrence rate and increase the survival time by combined chemotherapy. The significant prognostic factor for survival rate was the stage.
Breast Neoplasms* ; Breast* ; Disease-Free Survival ; Drug Therapy ; Follow-Up Studies ; Humans ; Lymph Nodes ; Mastectomy, Modified Radical ; Multivariate Analysis ; Recurrence ; Survival Rate ; Thoracic Wall

No abstract available.
Adenoma*

Cancer is the most common cause of death in Korea. Therefore, the care of terminally ill cancer patients represents a major issue of Korean welfare. Because of lack of hospice and palliative care education and government support, most terminally ill cancer patients are not given proper care with due human dignity. The hospice and palliative care education include a change of physicians attitudes toward patients and their family members control of symptoms, such as pain, for a high quality of life, total care with a team approach, and home care. When the physicians' attitudes become changed, the patient and his or her family would feel that they still retain human dignity and experience the best quality of life with the help of team approach. For the symptom control in terminally ill cancer patients, control of pain is most important and is possible in 97% of patients with opioids. Also, the medical costs are highest in terminal stage of cancer and hospice may be a solution to reduce the cost. The hospice insurance for the terminally ill cancer patients is covered by government in many oriental countries, such as Japan, Hongkong, Singapore, and Taiwan, because it can reduce medical costs and improve the welfare of patients. The joint committee of Korean Society of Hospice·Palliative care, Korean Hospice Care, and Catholic Hospice Care have been asking for the national hospice insurance to the Korean government since 1988, to no effect. In conclusion, the hospice and palliative care should be supported by government as well as medical field.
Analgesics, Opioid ; Cause of Death ; Education ; Home Care Services ; Hong Kong ; Hospice Care ; Hospices ; Humans ; Insurance ; Japan ; Joints ; Korea ; Palliative Care ; Personhood ; Quality of Life ; Singapore ; Taiwan ; Terminally Ill

No abstract available.
Genetic Therapy*

No abstract available.
Genetic Therapy*

To evaluate the difference of left ventricular diastolic function between pathological hypertrophy(hypertrophic cardiomyopathy) and physiological hypertrophy(hypertensive heart). Doppler echocardiography was used to study mitral flow velocity in 17 hypertrophic cardiomyopathy without obstruction, 32 hypertensive patients with left ventricular hypertrophy and 15 normal persons. From the M-mode echocardopgraphic measurement, hypertensive patients were diviede into two groups;group I;asymmetrical septal hypertrophy, group II;symmetrical septal hypertrophy. Early and late diastolic peak velocity, the ratio of late to early diastolic peak flow velocity and deceleration of early diastolic flow were measured from Doppler mitral flow velocity recordings. The results were as follows; 1) There were significant difference in E velocity between hypertrophic cardiomyopathy and hypertensive patients. 2) There were no significant difference in A velocity between hypertrophy cardiomyopathy and hypertensive patients. 3) E/A ratio was significantly decreased in hypertrophic cardiomyopathy and group II hypertensive patients compared to group I hypertensive patients. 4) There were no significant difference in deceleration of early diastolic flow between groups. The study shows that the diastolic dysfunction of hypertrophic cardiomyopathy is more severe than hypertensive patients with left ventricular hypertrophy. The reason is probably due to the more extentive myopathic process in free wall of hypertrophic cardiomypathy than physiological ventricular hypertrophy.
Cardiomyopathies ; Cardiomyopathy, Hypertrophic* ; Deceleration ; Echocardiography, Doppler ; Humans ; Hypertrophy ; Hypertrophy, Left Ventricular*

No abstract available.
Ankle* ; Foot* ; Humans ; Outpatients*

This study tried to find the prevalence and distribution of temporo-mandibulr disorders(TMD) for workers (employee) in Seoul area to investigate the correlation between TMD and possible etiological factors such as general muscle and joint symptoms, headache, unilateral chewing and parafunction. This study was an epidemiological investigation of answers obtained from 282 persons by questionaire from Aug. 1995 to Nov. 1995. The major findings from the questionaire were as follows. (1) 43.26% of the subjects(282 persons) has TMD. (41.88% of man and 43.26% of women) (2) The more often people have general muscle and joint symptoms and -headache, the more susceptible they are to TMD. Their correlation was very significant(p<0.001). (3) The more people have bad oral habits such as bruxism, clenching and biting habit, the more likely they have TMD. The more sensitive people are to stress, the more frequently they have bad oral habits such as bruxism, clenching and biting habit. (4) Unilateral chewing has higher TMD index than bilateral chewing. There is no relationship between ache areas and TMD index.
Bruxism ; Epidemiology* ; Headache ; Humans ; Joints ; Mastication ; Prevalence ; Seoul* ; Temporomandibular Joint Disorders

No abstract available.