PURPOSE: Frailty is a wasting syndrome common in old age and to confer high risk for morbidity and mortality. There is a growing consensus of the definition of frailty, but until now the diagnostic criteria is not clear yet. In the older male patients, almost of studies about testosterone replacement therapy performed to normal healthy population. And also only few studies were performed to the frail elderly patients. So we would like to investigate the effficacy of testosterone supplementation in the frail elderly. METHODS: Since May to Sep 2001, ambulatory elderly patients who were 65 years and over were recruited in the outpatient clinic of Asan Medical Center. All of them showed the typical characteristics of frailty symptom-weight loss, loss of muscle mass, weakness, fatigability, anorexia, inactivity. The patients who have sleep-apnea or previous history of prostate cancer were excluded. All patients were checked the serum PSA, total testosterone level, routine CBC, lipid, liver function test and evaluated prostate status with US or digital rectal examination, and treated with oral formula testosterone unde- canoate 80 mg daily. All patients were surveyed with ADL, IADL before the testosterone therapy and 3month later. RESULTS: A total of 6 male frail patients(mean age: 80+/-8.5) were enrolled. During 3 month Follow-up period, one was expired, 5 were finished the study. Before the testosterone replacement, mean total testos- terone level was 3.0+/-0.5 ng/ml and mean PSA was 1.3+/-0.7 ng/ml. After 3 months, blood hematocrit, cholesterol, total testosterone were not changed significantly and the body weight also showed insig- nificant increase. But after 3 months, all of them reported the increased well-being sensation, improved fatigability, weakness and improved ADL level. There were no significant adverse effects associated with testosterone replacement. CONCLUSION: In male frail elderly patients, the testosterone replacement therapy can be used safely, and can be improve the frailty associated symptom and ADL ability.
Activities of Daily Living ; Aged ; Ambulatory Care Facilities ; Anorexia ; Body Weight ; Cholesterol ; Chungcheongnam-do ; Consensus ; Digital Rectal Examination ; Follow-Up Studies ; Frail Elderly* ; Hematocrit ; Humans ; Liver Function Tests ; Male ; Mortality ; Prostate ; Prostatic Neoplasms ; Sensation ; Testosterone* ; Wasting Syndrome

No abstract available.
Thyroiditis, Autoimmune*

No abstract available.
Humans ; Infant*

No abstract available.
Brain Death* ; Brain*

No abstract available.
Humans ; Parturition* ; Spouses*

No abstract available.
Pediatrics*

No abstract available.
Humans ; *Peer Review, Research

Antineoplastic Agents ; adverse effects ; Carcinoma, Non-Small-Cell Lung ; epidemiology ; mortality ; pathology ; Erlotinib Hydrochloride ; Global Health ; Humans ; Lung Neoplasms ; epidemiology ; mortality ; pathology ; Protein Kinase Inhibitors ; adverse effects ; Quinazolines ; adverse effects ; Receptor, Epidermal Growth Factor ; Small Cell Lung Carcinoma ; epidemiology ; mortality ; pathology

PURPOSE: The purpose of this study was to compare the health status between foreign workers and native workers and to examine the influencing factors of health status of foreign and native workers. METHODS: This was a secondary analysis of the data collected from the 3rd (2011) Korean Working Conditions Survey (KWCS). The sample included 101 foreign workers and 101 native workers matched by age and gender. RESULTS: The difference in health status between foreign workers and native workers was not statistically significant. The most commonly complained health problem of foreign workers was muscle pain of the upper limbs. Among foreign workers, hazard exposure, coworker support and supervisor support were significant predictors of health status. Among native workers, income level and obesity were significant predictors of health status. CONCLUSION: For health management and health promotion of foreign workers, employers and health providers need to establish coworker supporting systems in workplace and improvement strategies of work environment. Particularly, they must pay closer attention to management of foreign workers' musculoskeletal disorder.
Health Promotion ; Myalgia ; Obesity ; Upper Extremity

No abstract available.
Allergy and Immunology*