The professional identity of medical postgraduates has great influence on their profes-sional learning, career development and realization of self-value. The effect factors of the professional iden-tity are as following:the conflict between personal needs and professional requirements, professional employ-ment prospect, the social recognition of medical profession and individuality. In this article, we suggest a feasible way to improve the professional identity for medical postgraduates by developing an interest in medical profession, optimizing specialty structure and improving personal comprehensive quality.

[摘 要] 目的：筛选炎症性肠病（IBD）和结直肠癌（CRC）的潜在共病基因，探讨关键基因去整合素-金属蛋白酶8（ADAM8）与IBD及CRC发生发展的关系及其潜在机制。方法：基于从GEO数据库和TCGA数据库下载IBD及CRC患者的转录组数据及对应临床资料，通过差异分析、预后基因筛选及交集分析鉴定同致共病基因。用多个数据集分析和验证关键基因ADAM8在IBD及CRC中的表达特征及其与临床病理指标的关系。生存分析探究ADAM8在CRC中的预后价值。功能和通路富集分析探究ADAM8影响CRC进展的潜在机制，进一步用肿瘤微环境算法评估ADAM8与肿瘤微环境的关系。用免疫组化（IHC）法检测中国人CRC组织中的表达验证数据库数据。结果： ADAM8为IBD和CRC的潜在关键共病基因。ADAM8在IBD和CRC组织中均呈高表达（均P < 0.01），且其高表达提示疾病病理进展（P < 0.01）。高表达ADAM8的CRC患者总生存期（OS）更短（P < 0.05或P < 0.01）。ADAM8在中国人CRC组中也呈高表达（P < 0.01）。免疫细胞迁移、细胞因子产生及免疫受体相互作用等通路与ADAM8表达密切关联，ADAM8表达与中性粒细胞、巨噬细胞等免疫细胞浸润水平呈正相关（P < 0.01或P < 0.001）。结论：ADAM8在IBD和CRC组织中呈高表达，与患者预后、疾病进展及免疫细胞浸润密切关联，有望成为2种疾病的共同干预靶点。

【Objective】 To detect the anti-SARS-CoV-2 antibody levels in blood donors in Guangzhou, so as to provide laboratory data support for the collection and clinical use of convalescent plasma. 【Methods】 Anti-SARS-CoV-2 antibodies were measured by ELISA in qualified donors. Among them, 326 donors who gave blood in February 2023 were tested for IgG antibodies, 444 donors were tested for neutralizing antibodies. In July 2023, 398 donors were tested for IgG and IgM. 【Results】 399 of 724 blood samples diluted with normal saline (1∶160) were IgG reactive, with a reactive rate of 55.11%. Chi-square test showed that there was a significant difference in the reactive rate of IgG among samples collected at different times (25.46% in February vs 79.40% in July, χ²=210.74, P<0.01, 95%CI: 7.97, 15.98), but there was no significant difference in the reactive rate between different genders and different age groups. IgM was detected in 5 of 398 blood samples, with a reactive rate of 1.26%. The IgG test results of these five blood donors were all reactive, whereas the nucleic acid test results were negative. Neutralizing antibody was detected in 440 of 444 blood samples, with a reactive rate of 99.10%, and 71.59% of the reactive donors had a neutralizing antibody level of 10 μg/mL or more. 【Conclusion】 Blood donors in Guangzhou have a high level of SARS-CoV-2 antibody, which is sufficient to provide convalescent plasma for clinical treatment.