Objective:To investigate whether knee osteoarthritis has an impact on the patient′s depression and whether it′s progression will affect the patient′s depression, and to provide a reference for clinical work.Methods:Patients diagnosed with osteoarthritis in Dalian Central Hospital from 2016 to 2019 were divided into 4 groups according to Kellgren-Lawrence staging, and the patients were scored on WOMAC scale, AKSS clinical scale, and AKSS. The score of the scale and the score of the HAMD scale were collected and statistically analyzed using SPSS 17.0.Results:χ2 test was used to show that there was no difference in the gender composition of patients in different stages ( P<0.05). The AKSS clinical scale score, AKSS functional scale score, WOMAC scale score and HAMD scale score were statistically analyzed for each stage. The results showed that the average AKSS clinical scores of patients in each stage were as follows: stage Ⅰ: (90.01 ± 8.41) points; stage Ⅱ: (79.98 ± 10.93) points; stage Ⅲ: (71.78 ± 13.64) points; stage Ⅳ: (54.18 ± 12.58) points. The AKSS functional scores were as follows, stage Ⅰ: 100 points; stage Ⅱ: 80 points; stage Ⅲ: 70 points; stage Ⅳ: 45 points; the average WOMAC scale scores of patients in each stage were as follows, stage Ⅰ: (28.69 ± 19.22) points ; stage Ⅱ: (49.43 ± 22.69) points; stage Ⅲ (70.13 ± 24.84) points; stage Ⅳ: (107.79 ± 24.39) points. The average HAMD scale scores of patients in each stage were as follows, stage Ⅰ: (4.89 ± 3.42) points; stage Ⅱ: (7.65 ± 4.20) points; Stage Ⅲ: (9.05 ± 5.03) points; stage Ⅳ: (12.35 ± 5.41) points. The analysis showed that there were significant statistical differences in the scale scores between each period ( P<0.05). There was a correlation between the patient′s depression status and the patient′s age, pain, and joint function, and there were statistical differences ( P<0.05). Conclusions:There is a significant correlation between depression and pain and function in patients with knee osteoarthritis. The progress of the osteoarthritis course will aggravate the patient′s depression state. Conversely, the patient′s depression state can also aggravate the symptoms of osteoarthritis patients and affect the clinical efficacy of the patients.

Objective To evaluate the diagnostic values of diffusion weighted MRI(DWI)and contrast-enhanced magnetic resonance imaging(CE-MRI)using gadolinium chelates in patients with brain abscesses.Methods Conventional TlWI,T2WI,fluid attenuated inversion recovery(FLAIR),DWI and gadolinium-enhanced MRI were performed in 49 patients with single cystic/solid brain lesions.Retrospective analysis of the DWI signals and enhancement characteristics of patients with brain abscesses(n=22)and with cystic/necrotic brain tumors(n=27)was performed; meanwhile,measurement of the ADC values of the necrotic areas was performed.DWI combined with conventional sequences (group Ⅰ),CE-MRI combined with conventional sequences(group Ⅱ),and DWI,CE-MRI and conventional sequences(group Ⅲ)were employed to calculate their sensitivity,specificity,positive predictive value,negative predictive value and accuracy; these results were compared with the pathological results.Results The high DWI signal was noted in 20 patients with brain abscesses,and low DWI signal in 24 patients with cystic/necrotic brain tumors.Evenly thin walls and a ring enhancement under enhanced scan were noted in 14 patients with abscesses and 12 patients with cystic/necrotic brain tumors.Most of the ADC values in patients with brain abscesses were significantly lower than those in patients with cystic/necrotic brain tumors(P＜0.05).The diagnostic sensitivity to brain abscess in group I,group Ⅱ and group Ⅲ were 90.9％,63.6％ and 95.5％,respectively; the difference was statistically significant between group Ⅰ and group Ⅱ(P＜0.05),and between group Ⅱ and group Ⅲ(P＜0.05),but not between group Ⅰ and group Ⅲ(P＞0.05).Conclusion DWI is more sensitive in detecting the brain abscess than CE-MRI,and the measurement of ADC values can provide valuable differential diagnostic information for patients with brain abscess and cystic/necrotic brain tumor.