1.The Efficacy of Levofloxacin Based Triple Therapy for Helicobacter pylori Eradication.
Ji Hyun LEE ; Sung Pyo HONG ; Chang Il KWON ; Lea Hyun PHYUN ; Byoung Sok LEE ; Han Ul SONG ; Kwang Hyun KO ; Seong Gyu HWANG ; Pil Won PARK ; Kyu Sung RIM ; Sehyun KI
The Korean Journal of Gastroenterology 2006;48(1):19-24
BACKGROUND/AIMS: The failure rates of first and second line therapies of Helicobacter pylori (H. pylori) eradication range from 15 to 20%. This study was aimed to evaluate the efficacy and safety of levofloxacin based triple therapy compared with standard triple or quadruple therapy for H. pylori eradication in Korea. METHODS: We enrolled two hundred and sixty seven patients with presence of H. pylori infection. One hundred and forty-one patients were treated with levofloxacin based triple therapy (LAP; levofloxacin, amoxicillin, proton pump inhibitor; PPI), and 126 patients were treated with standard triple therapy (CAP; clarithromycin, amoxicillin, PPI). We retreated the patients who had failed in H. pylori eradication with standard quadruple second-line therapy (MTPB; metronidazole, tetracycline, PPI, bismuth subcitrate) or levofloxacin based therapy (LAP or LCP; levofloxacin, clarithromycin, PPI). RESULTS: In first line therapy of H. pylori eradication, the eradication rates of levofloxacin based triple therapy and standard triple therapy were 69.8% and 74.0% respectively (p=0.52). In second-line therapy, the eradication rate of levofloxacin based triple therapy and standard quadruple therapy were 62.5% and 40.0% respectively (p=0.34). CONCLUSIONS: Levofloxacin based triple therapy is effective as standard regimen to eradicate H. pylori infection and is useful for an alternative rescue therapy as well.
Adult
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Aged
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Anti-Bacterial Agents/*administration & dosage
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Drug Therapy, Combination
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Female
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Helicobacter Infections/*drug therapy
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*Helicobacter pylori
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Humans
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Male
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Middle Aged
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Ofloxacin/*administration & dosage