1.Ecology suitability study of Cistanche deserticola in Alxa.
Zhen-hua LI ; Yan-fang WANG ; Le-tai YI ; Ai-hua ZHANG ; Kai REN ; Chun-hong ZHANG ; Ya-qiong BI ; Min-hui LI
China Journal of Chinese Materia Medica 2015;40(5):785-792
The distribution information of Cistanche deserticola was collected by interview investigation and field survey, and 55 related environmental factors were collected, the habitat suitability study was conducted based on geographic information system (GIS) and Maximum entropy model. The AUCs of ROC curve were both above 0.9, indicating that the predictive results with the maxent model were highly precise. The results showed that 14 major environmental factors have obvious influence on ecology suitability distributions of C. deserticola, including vegetation type et al, the suitable distribution areas are mainly concentrated in the central of Alxa Youqi, the north of Alxa Zouqi and the south-east of Ejin Banner, including Tamusu towns, Alateng towns et al, The zoning results basically coincide with the genuine producing areas, and further afford new suitable distribution areas, which can provide reference for the siting of introduction and cultivation of C. deserticola.
China
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Cistanche
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growth & development
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Ecosystem
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Environment
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Geographic Information Systems
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Rain
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Soil
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chemistry
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Temperature
2.Status analysis and strategic thinking on Mongolian medicine standardization.
Xiang-Hui ZHU ; Le-Tai YI ; Min-Hui LI
China Journal of Chinese Materia Medica 2018;43(16):3412-3416
Standardization is the progress of human civilization. It is also an important technical system for normalizing economy and social development and a basic element in the core competitive power of a country. This paper emphasized on the importance of accelerating the standardization of Mongolian medicine for international development of national medicine and improving the international competitiveness. Summed up the Mongolian medicine standardization work achieved the stage results. Achievements on Mongolian medicine standardization were summarized and the existed problems were also analyzed. Such as, imperfect Mongolian medicine standard system and operation mechanism, the lack of application and personnel of Mongolian medicine. Corresponding measures, such as improving the Mongolian medicine standardization system and its support system construction; establishing personnel long-term training mechanism; the establishment of Mongolian medicine standard implementation-promotion-evaluation-feedback mechanism and other corresponding measures, were also provide.
3.Application of " Basaga" in Mongolian Medicine Compound Preparations in Inner Mongolia
Hua XIAO ; Xiang-hui ZHU ; Ming-yue JI ; Le-tai YI ; Min-hui LI
Chinese Journal of Experimental Traditional Medical Formulae 2020;26(3):190-198
" Basaga" is one of the commonly used medicinal materials in Mongolian medicine. It has a long history and effects in cooling blood, stopping stabbing pain and detoxifying. The " Basaga" in Mongolian medicine compound preparations have been widely used in various Mongolian hospitals because of its remarkable clinical efficacy. However, due to the differences in inheritance, medicinal parts and plants in Inner Mongolia, the phenomena of homonym and synonym in the application of " Basaga" have been very obvious, which leads to confusion in clinical use, and challenges the safety and effectiveness of this kind of Mongolian medicine. To understand the application of " Basaga" in Mongolian medicine compound preparation, and collect and summarize the types of " Basaga" preparations and the variety of " Basaga" used in preparations and formulations, functional indications and clinical applications were analyzed and collected based on standards and specifications of Mongolian medicine, the application of Mongolian medicine hospitals and Mongolian medicine hospital' s preparation room in Inner Mongolian, and relevant documents in recent years were reviewed. The data can provide references for optimizing and improving " Basaga" , Mongolian medicine standards and the overall standard level. What' s more, the basic data for strengthening the comprehensive development and research of " Basaga" in Mongolian medicine compound preparations in future, so as to ensure and improve the accuracy and clinical effectiveness of " Basaga" in prescriptions of Mongolian patent medicine, and lay a foundation for rational use and modern research of " Basaga" Mongolian medicine.
4.Application and analysis of ethnic medicines in "Three Minorities" in Inner Mongolia.
Ya-Qiong BI ; Le-Tai YI ; Yu SUN ; Wen-Fang GUO ; Lei ZHANG ; Chun-Hong ZHANG ; Min-Hui LI
China Journal of Chinese Materia Medica 2019;44(15):3162-3169
This paper investigates and counts the ethnic medicines of the Ewenki,Daur and Oroqen ethnic groups,which are known as the " Three Minorities" in Inner Mongolia. Through the methods of literature collection,interview investigation,and resource investigation,different ethnic medicines were collected on the main diseases,drug varieties,drug-injection sites,and drug administration methods. Through data statistics and SPSS analysis,the similarities and individual differences between the three ethnic groups were clarified. The results indicated the predicament of the current national medicine,which is helpful for the protection and inheritance of ethnic medicine.
China
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Ethnic Groups
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Ethnopharmacology
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Humans
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Mongolia
5.Identification and analysis of anti-diabetic drugs based on terahertz time-domain spectroscopy
Han LI ; Ping DONG ; Jia-tai WANG ; Shao-qing DU ; Hong LI ; Le XIE ; Lin CHEN ; Yi-ming ZHU
Journal of Medical Biomechanics 2011;26(6):E555-E559
Objective To study the vibration frequencies and resonant peaks of different molecular groups in anti-diabetic drugs and to investigate the absorption spectra of these drugs in the range of terahertz, so as to accurately and efficiently identify similar drugs and provide foundation for understanding the contribution of such vibration in different molecular groups to pharmacology. Methods Using terahertz time domain spectroscopy (THz-TDS), six kinds of similar diabetes pills for treating diabetes mellitus (DM), including gliquidone, glipizide, gliclazide, glimepiride, repaglinide and metformin were tested to obtain their absorption spectra from 0.3~3.0 THz. Support vector machines (SVM) method was employed to separate these anti-diabetic drugs by selecting the experimental data from 1.5~2.0 THz. Results For gliquidone, glipizide, gliclazide, and glimepiride, an obvious resonance peak was found at 1.37 THz. According to the THz spectra, repaglinide and metformin could be easily separated from sulfonylurea drugs. Furthermore, with the help of SVM, the accuracy of discrimination for four kinds of sulfonylurea could reach 100%. Conclusions THz technology, as a new testing method, shall play a positive role in the drugs for their identification, quality control and distinguishing their chemical bonds/functional group.
6.Effect of fudosteine on lung cancer cells in an inflammatory microenvironment based on metabolomics
Yi-fei WANG ; Qi-le ZHANG ; Xin LI ; Meng-ting GAO ; Li ZHANG ; An-wei DING ; Wen-yu XIA ; Wei-feng YAO
Acta Pharmaceutica Sinica 2022;57(2):419-427
GC-MS metabolomics was used to investigate the effects of fudosteine on lung cancer A549 cells in an inflammatory microenvironment. Eleven metabolites (malic acid, isoleucine, lactose, galactinol, creatinine, gluconic acid, oleic acid, phosphate,