1.Contribution to the study on the anti-inflammatory mechanism of alpha-chymotrypsin and papaine
Pharmaceutical Journal 1998;265(5):15-17
Both of alpha-chymotrypsin and papain were active in hydrolysis of proteins by temperature, acid and alkali proteins. Alpha-chymotrypsin hydrolysed protein better than papain. They were effective in digestion of mouse protein in inflamed tissue by Kaolin, Dextran and Formal in different level according this increasing order: Kaolin < Dextran < Formal. -chymotrypsin was better than papaine in hydrolysis of protein in inflamed tissue. Therefore, we can explain the anti inflammatory characters of those enzymes.
Chymotrypsin
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Papain
2.Anti-inflammatory effects of flavonoids from Lonicera japonica Thunb. Caprifoliaceae in combination with ?-amylase
Pharmaceutical Journal 2005;347(3):8-11
In vitro, flavonoids from Lonicera japonica Thunb flavonoids stimulate the catalysis of hydrolysis starch. This stimulating effect depended on the concentration of Lonicera japonica flavonoid but their in vitro stimulations weren’t strong. The anti-inflammatory effects were stronger when combining flavonoid with -amylase on dextran-induced edema mouse legs. So active catalysis stimulation of -amylase could be associated with anti-inflammation process; with unclear mechanisms. This result suggested the need of further research of anti-inflammatory drugs according to combine of traditional medicine and anti-inflammatory enzyme
Flavonoids
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Anti-Inflammatory Agents
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Lonicera
3.Contribution to the study on anti-inflammatory effect of flower of Lonicera japonica Thunb. in association with alpha - chymotrypsine
Pharmaceutical Journal 2003;234(4):13-15
Researching in test mouse. Result: In vivo, Honeysuckle flower have a acute anti-inflammatory effect when used alone as well as its combination with alpha-CT. In vitro, honeysuckle flower have a stimulate effect of the activity alpha-CT. The successful combination of decoction and honeysuckle flower (flavonoid) with alpha-CT(in vitro and in vivo) took a little part in studying the anti-inflammatory mechanism of honeysuckle flower with alpha-CT. The synergic effect of above two active element induced which give satisfactory anti-inflammatory effect, which was equivalent to some of modern medicine of use to anti-inflammatory drug.
Flowers
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Anti-Inflammatory Agents
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Flavonoids