1.The efficacy of laparoscopic surgery for patients with tubal factor infertility
Ho Chi Minh city Medical Association 2005;10(2):73-76
Survey 140 patients with tubal factor infertility at Tu Du Hospital from 2002 to 2003. Intrauterine pregnancy rate was 19.3% and ectopic pregnancy rate was 9.3%. Patient’s age is one of factors influencing the outcome of laparoscopic surgery. The elder patients are, the lower pregnancy rate they get (for patients over 35 years old, pregnancy rate is as low as 4%). The level of tubal damage and adhesion are also influencing factors for rate of intrauterine pregnancy. The more severe damage and adhesion patients had, the lower pregnancy rate they get. The prognosis of tubal factor infertility was highly associated with the level of tubal damage and patient’s age. Laparoscopic surgery for tubal obstruction is only effective for cases with mild or moderate lesion. For elder cases over 35 years old or severe tubal damage, IVF-ET should be indicated
Infertility
;
Laparoscopy
;
Sterilization, Tubal
2.Therapeutic approaches for uterine fibroma
Ho Chi Minh city Medical Association 2005;10(5):293-300
There is about 30% of women experienced uterine fibroma and most of them needn’t treatment. For symptomatic women, various medical treatments were more and more extensive. Surgical treatments were indicated depending on many factors and individual patient. Besides traditional therapies (myomectomy, hysteroscopic myomectomy, uterine endoscopy, etc), there were more and more new techniques such as uterine artery embolization. This technique is relative new and minimal invasive of management, but it still needs further research
Leiomyoma
;
Therapeutics
3.Clinical characteristics of poststroke dementia patients with age of 60 years and older
Van Thanh Nguyen ; Thang -- Pham ; Cuong Quang Le ; Van Thanh Ta
Journal of Medical Research 2007;47(2):79-85
Background: Dementia is one of the major causes of dependency after stroke. The prevalence of poststroke dementia (PSD)defined as any dementia occurring after stroke is likely to increase in the future.Objectives: This study have two purposes: 1) Clinical study of MCI and dementia after the first stroke of patients with age of 60 years and older; 2) Overview on clinical characteristics of memory disorders. Subjects and method: 30 patients with were diagnosed with the first ischemic stroke in Huu nghi hospital together with the same number in the control group were involved in this study. The subjects in the two groups were all satisfied with included/excluded criteria diagnosis. Clinical diagnosis of new - onset dementia or other mental disorders was determined using neuropsychological tests. Results: Many functions of the brain were impaired including: logical memory, visiospatial skills, executive function were statistically reduced in the research group compared to the control. However, language function was also impacted but not as much as others. The frequency of the poststrocke dementia in this study was 12.3% while the poststrocke mild cognitive impairment rate was 47%. Conclusions: Global cognitive functioning together with memory state was significantly declined in the ischemic stroke compared to the control group.
Stroke/ pathology
;
complications
;
Dementia/ pathology
;
complications
4.Application of neuropsychological battery tests in post-stroke dementia diagnosis among patients over 60 years old
Van Thanh Nguyen ; Thang -- Pham ; Cuong Quang Le ; Van Thanh Ta
Journal of Medical Research 2008;54(2):56-62
Background: In Vascular Dementia (VaD) patients, the causes of blood vessels were common, and preventable and treatable, so that it is very important to detect and diagnose in the early stages of the disease. Diagnosis of dementia is based on clinical symptoms, and neuropsychological tests are useful tools. Objectives: (1) To evaluate the severity of VaD and Vascular Cognitive Impairment (VCI) after the 1st ischemic stroke in patients over 60 years old. (2) To make observations on the clinical features of post stroke dementia in these patient groups using neuropsychological battery. Subjects: 94 patients with 1st acute ischemic stroke, who were over 60 years old, conscious and literate, and cooperated well with physicians. A standard evaluation protocol was conducted at one month after an ischemic stroke for all the patients. Method: Prospective study. Data was analyzed by using SPSS software version 13.0. Results and conclusions: The rates of VCI and VaD after the first ischemic stroke were 21.3% and 25.5%, respectively. Clinical determinants of dementia were: visuoconstruction (65% patients), visual motor speed (50%), memory disorders (more than 40%, in which visual memory 45.8% and verbal memory 41.6%), executive function (37.5%), and language skill (37.5%). The attention and language functions were less affected (only 25% of the patients). Mini mental state examination score can be used to evaluate and classify clearly 3 groups: VaD, VCI patients and normal people.
Ischemic stroke
;
Dementia
;
Neuropsychological test
5.Laparoscopic surgery in Quang Tri General Hospital
Thanh Van Le ; Viet Khanh Phan ; Hung Nam Tran ; Dung Xuan Nguyen ; Quang Phuoc Hoang
Journal of Surgery 2007;57(1):24-29
Background: Laparoscopic cholecystectomy is the first laparoscopic surgery that was performed at Cho Ray hospital in September 1992. In 2005, Quang Tri general hospital has performed successfully the first case of laparoscopic appendectomy. Objectives: To access the preliminary results of application on endoscopic surgery in Quang Tri general hospital. Subjects and method: A prospective study was conducted on 140 patients with laparoscopic surgery or retroperitoneal surgery, was performed in Quang Tri general hospital from September, 2005 to April, 2006. Results:Among 140 patients was operated, there was only one case of postoperative intestinal obstructive complication (accounted for 0.7%), no case of death. Operative aged was between 11 and 70 years old. The average surgical time was 65 minutes for cholecystectomy, 35 minutes for appendectomy, 85 minutes for ureterolithotomy, 80 minutes for gynecological diseases. 2 cases of cholecystectomy and appendectomy changed open surgery. Conclusion: Laparoscopic surgery is a safe and effective method. It can be developed in provincial hospitals. Quang Tri general hospital has successful preliminary developed the new technique.
Laparoscopy
;
6.Results for cardiac intervention in National Hospital of Pediatrics
Quang Hong Le ; Truong Van Pham ; Tung Viet Cao ; Hoa Huu Pham ; Liem Thanh Nguyen
Journal of Medical Research 2007;55(6):1-5
Background:The progress of the cardiac intervention technique has been changed the doctors' viewpoint in the treatment for congenital cardiac. In the past years, treatment for congenital cardiac needed to surgery but nowadays, the cardiac intervention technique are being applied in many Cardiac Centers with very good results. This technique also helped to prevent the complication in cardiac operation. Objectives:This study aims to report the results for cardiac intervention in National Hospital of Pediatrics. Subjects and method:A prospective study was conducted on 298 children diagnosed with patent ductus arteriosus, atrial septal defect (ASD), ventricular septal defect, coarctation, pulmonary stenosis (PS), aortic stenosis (AS), small patent ductus arteriosus (PDA) infant with pulmonary atresia - ventricular septal defect (VSD) and Dextro- transposition of the great arteries (d- TGA) with intact ventricular septum at National hospital of Pediatric between June 2004and October 2006. Results: Transcatheter closure of PDA, ASD by Amplatzer or Coil was safe and effective. Critically ill children diagnosed with PS, AS and Coarctation may be saved by valvuloplasty and angioplasty procedures. Catheter interventions avoided the needs for surgery without scars. Catheter interventions had low complications. Conclusion: The hospitalized duration was short so the expenditures reduced.
Heart Defects
;
Congenital/ epidemiology
;
therapy
7.Saponins from the Leaves of Panax vietnamensis Ha et Grushv. (Vietnamese ginseng) and Their Inhibitory Activities on α-Glucosidase
Hoang Khang LE ; Thanh Tung PHAN ; Thi Thuy Duong NGO ; Cong Luan TRAN ; Poul Erik HANSEN ; Quang Ton THAT
Natural Product Sciences 2024;30(4):237-243
Vietnam boasts a rich and diverse flora, with many endemic species. Among them, Ngoc Linh ginseng (Vietnamese ginseng; scientific name: Panax vietnamensis Ha et Grushv.), a high-value endemic ginseng species, has been recognized as a national treasure. While numerous studies have been conducted on its rhizomes and roots, research on its leaves remains limited. In this study, six compounds (1–6) were isolated from the methanol extract of the leaves of P. vietnamensis. Their structures were elucidated using ESI-MS, 1D and 2D NMR spectroscopic methods, and comparisons with known literature data. The identified compounds are: 12β,20(R),25-β trihydroxydammara-3-O-β-D-glucopyranoside (1); 12β,20(R),25-trihydroxydammara-3-O-β-D-glucopyranosyl- (1→2)-β-D-glucopyranoside (2); notoginsenoside SFt1 (3); ginsenoside Rh2 (4); ginsenoside Rg3 (5) and notoginsenoside L1 (6). Except for compound 3, which was isolated from the leaves for the first time, the other five compounds are reported from this species for the first time. The α-glucosidase inhibition assay of the pure isolated compounds revealed that compounds 1, 4, and 6 exhibited significant activities, with IC50 values of 133.5, 105.5, and 14.9, respectively. For comparison, the positive control, acarbose, had an IC50 value of 138.2 µM.
8.Saponins from the Leaves of Panax vietnamensis Ha et Grushv. (Vietnamese ginseng) and Their Inhibitory Activities on α-Glucosidase
Hoang Khang LE ; Thanh Tung PHAN ; Thi Thuy Duong NGO ; Cong Luan TRAN ; Poul Erik HANSEN ; Quang Ton THAT
Natural Product Sciences 2024;30(4):237-243
Vietnam boasts a rich and diverse flora, with many endemic species. Among them, Ngoc Linh ginseng (Vietnamese ginseng; scientific name: Panax vietnamensis Ha et Grushv.), a high-value endemic ginseng species, has been recognized as a national treasure. While numerous studies have been conducted on its rhizomes and roots, research on its leaves remains limited. In this study, six compounds (1–6) were isolated from the methanol extract of the leaves of P. vietnamensis. Their structures were elucidated using ESI-MS, 1D and 2D NMR spectroscopic methods, and comparisons with known literature data. The identified compounds are: 12β,20(R),25-β trihydroxydammara-3-O-β-D-glucopyranoside (1); 12β,20(R),25-trihydroxydammara-3-O-β-D-glucopyranosyl- (1→2)-β-D-glucopyranoside (2); notoginsenoside SFt1 (3); ginsenoside Rh2 (4); ginsenoside Rg3 (5) and notoginsenoside L1 (6). Except for compound 3, which was isolated from the leaves for the first time, the other five compounds are reported from this species for the first time. The α-glucosidase inhibition assay of the pure isolated compounds revealed that compounds 1, 4, and 6 exhibited significant activities, with IC50 values of 133.5, 105.5, and 14.9, respectively. For comparison, the positive control, acarbose, had an IC50 value of 138.2 µM.
9.Saponins from the Leaves of Panax vietnamensis Ha et Grushv. (Vietnamese ginseng) and Their Inhibitory Activities on α-Glucosidase
Hoang Khang LE ; Thanh Tung PHAN ; Thi Thuy Duong NGO ; Cong Luan TRAN ; Poul Erik HANSEN ; Quang Ton THAT
Natural Product Sciences 2024;30(4):237-243
Vietnam boasts a rich and diverse flora, with many endemic species. Among them, Ngoc Linh ginseng (Vietnamese ginseng; scientific name: Panax vietnamensis Ha et Grushv.), a high-value endemic ginseng species, has been recognized as a national treasure. While numerous studies have been conducted on its rhizomes and roots, research on its leaves remains limited. In this study, six compounds (1–6) were isolated from the methanol extract of the leaves of P. vietnamensis. Their structures were elucidated using ESI-MS, 1D and 2D NMR spectroscopic methods, and comparisons with known literature data. The identified compounds are: 12β,20(R),25-β trihydroxydammara-3-O-β-D-glucopyranoside (1); 12β,20(R),25-trihydroxydammara-3-O-β-D-glucopyranosyl- (1→2)-β-D-glucopyranoside (2); notoginsenoside SFt1 (3); ginsenoside Rh2 (4); ginsenoside Rg3 (5) and notoginsenoside L1 (6). Except for compound 3, which was isolated from the leaves for the first time, the other five compounds are reported from this species for the first time. The α-glucosidase inhibition assay of the pure isolated compounds revealed that compounds 1, 4, and 6 exhibited significant activities, with IC50 values of 133.5, 105.5, and 14.9, respectively. For comparison, the positive control, acarbose, had an IC50 value of 138.2 µM.
10.Saponins from the Leaves of Panax vietnamensis Ha et Grushv. (Vietnamese ginseng) and Their Inhibitory Activities on α-Glucosidase
Hoang Khang LE ; Thanh Tung PHAN ; Thi Thuy Duong NGO ; Cong Luan TRAN ; Poul Erik HANSEN ; Quang Ton THAT
Natural Product Sciences 2024;30(4):237-243
Vietnam boasts a rich and diverse flora, with many endemic species. Among them, Ngoc Linh ginseng (Vietnamese ginseng; scientific name: Panax vietnamensis Ha et Grushv.), a high-value endemic ginseng species, has been recognized as a national treasure. While numerous studies have been conducted on its rhizomes and roots, research on its leaves remains limited. In this study, six compounds (1–6) were isolated from the methanol extract of the leaves of P. vietnamensis. Their structures were elucidated using ESI-MS, 1D and 2D NMR spectroscopic methods, and comparisons with known literature data. The identified compounds are: 12β,20(R),25-β trihydroxydammara-3-O-β-D-glucopyranoside (1); 12β,20(R),25-trihydroxydammara-3-O-β-D-glucopyranosyl- (1→2)-β-D-glucopyranoside (2); notoginsenoside SFt1 (3); ginsenoside Rh2 (4); ginsenoside Rg3 (5) and notoginsenoside L1 (6). Except for compound 3, which was isolated from the leaves for the first time, the other five compounds are reported from this species for the first time. The α-glucosidase inhibition assay of the pure isolated compounds revealed that compounds 1, 4, and 6 exhibited significant activities, with IC50 values of 133.5, 105.5, and 14.9, respectively. For comparison, the positive control, acarbose, had an IC50 value of 138.2 µM.