Artemisinine was prepared into a suspension suitable for subcutaneous administration in Plasmodium berghei- infected mice. This formulation (20mg/kg b.i.d, total dosage of 200mg/kg) was compared to oral artemisinine (at the same dose) in 50 Plasmodium berghei infected mice. The study also included a non treated control group and a placebo suspension group. The drug was applied for 5 days, beginning at 4 hours after infection. All mice treated by subcutaneous application were alive and did not show any toxicity or side effects due artemisinine. There was no recrudescence during 60 days of follow-up. All mice in the control, placebo and oral artemisinin group died with hyperparasitemia. The result showed that subcutaneous formulation of artemisinin is more effective than oral ones at the same dose.
Artemisinine ; Plasmodium berghei

The effect of deworming on nutritional status and anemia were studied on 277 children aged 30-60 months in 3 rural commune in An Giang province (Mekong Delta). A dose of 500mg of mebendazol improved dramatically the body weight and the weight of children. 6 months after the deworning, in intervened group, the gam of weight and height reached 0.3kg and 0.8cm respectively in comparing with control group. Similarly the change in WAZ and HAZ was also higher in the intervened group than the control group (0.13 and 0.17 units respectively). Anemia incidence decreased by 12.1% while in the control group 5.6%. Mean level of hemoglobine in intervened group was 0.4g/dl higher than control.
child ; Infant Nutrition Disorders ; Anemia

27 patients with the diagnosis of bone fractures of the limbs with injury of peripheral vessels were treated in Viet Tiep Hospital, Hai Phong city from January 2001 to November 2002. Their majority was male persons of productive age and the main cause was traffic casualties 74%, among them underwent early operation within 6 hours. 6 patients underwent a bone combination with intraspinal nail or Kirchner needle. Among 23 preserved cases, only in 8 cases, the function of the limbs was well rehabilitated, the rest were moderate and bad. In 4 cases, it must undergo an amputation at 2nd time because the late diagnosis and had been missing.
Fractures, Bone ; Diagnosis ; Therapeutics

Establish DNA polymorphism methods (PCR/RFLP) with marker Bcl1 restriction enzyme on intron 18 for detecting mothers who carried an abnormal X chromosome with hemophilia and transfer to their sons. 4 of 9 families carried intron 18-related mutations of hemophilia A and these mothers transfered mutations to their sons to cause hemophilia patients
Hemophilia A ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length

Leaves of Telosma cordata were leached with methanol several times at room temperature, after rejecting solvent at low pressure, methanol were tested cytotoxic activities and antioxidant activities. Results: methanol extracts showed in vitro cytotoxic activities against Hep-G2 (heptonema carcinoma), Fl (fibril sarcoma of uterus) and RD (rhabdosarcoma) with the ED values of 39.0%, 12.6% and 5.6%, respectively. Methanol extracts showed antioxidant activities with SC=52.3±0.9% and IC50=56.9µg/ml. Four compounds: luteine (1), 1-dotriacontanol (2), 24E-stigmasta-5,22-dien-3 B-ol (3), and daucosterol (4) were isolated from the n-hexalle extracts
Plants, medicinal ; Medicine, Traditional

A new spectrophotometry was described for the simultaneous analysis of pseudoephedrine sulfate-Ioratadine combination. The derivative spectrophotometry dA/d values were read at zero-crossing point. Mean recoveries were found to be more than 98% for these compound in mixture. The procedure does not require any separation step and proven to be rapid, simple and accurate for determination of the mentioned sample or corresponding multi-component mixture
Spectrophotometry ; Ultraviolet Therapy ; Loratadine ; tablets

In the study, 25 consecutive eyes of 25 patients (21 men, 4 women; mean age: 45 ± 8.5 years; range 30 to 58 years) with central serous chorioretinopathy were examined with optical coherence tomography (OCT) during acute phase and after the resolution of the retinal detachment. Cross-sectional retinal images through the center of the fovea were obtained from all eyes by OCT. The retinal thickness at the fovea center was measured. All of patients were conducted fluorescent angiographies. In the acute phase, neurosensory retina was thickened within the area of serous retinal detachment in all 25 eyes. The retinal thickness at the center of the fovea during the acute phase (range, 162 to 273µm; mean ± SD, 192 ±18 µm) was significantly thickened in comparison with that after resolution (range, 98 to 149 µm; mean± SD, 117±12.7µm). The retinal pigment epithelium was focally detached in five eyes
Eye Diseases ; Diagnosis

From Nov.2001 to July 2003, the analysis of chromosomes of 92 patients with CML evealed the metaphase figure of chromosomes of bone marrow cell which will be obtained easier than blood, but the blood is better Philadelphia chromosome found in 91,25% of cases of success.There is no significant difference between male and female subjects as between various age groups
Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; Philadelphia Chromosome ; Bone Marrow Cells

This study was carried out in 47patients (47 eyes) with traumatic optic neuropathy admitted Cho Ray Hospital from March 2003 to March 2004, among them 39 cases were treated by high-dose corticoids. The percentage of traumatic optic neuropathy was 0.32% of all head trauma cases. Among 47 patients, there were 44 males, 3 females, mean age: 30 years old, lesions were in 18 right eyes and 29 left eyes, traffic accidents were in 46 cases (97.9%), mainly were motorcycle accidents. The mean duration for finding lesions is 20 hours and mean duration for treating is 37 hours. Visual acuity was severely decreased: 76.6% patients with no light perception, 85% patients with no light perception and light perception. Concomitant traumas included injuries in ear, nose and throat trauma (51.1%), teeth (40.4%), head (38.3%). CT scan finding revealed fractures of orbit in 19 cases (40.4%), of optic canal in 6 cases (15%). Treatment with high-dose corticoids (methyl-prednisolone IV 500mg-1999mg a day) for 39 cases had more effective than no treatment or low-dose corticoids (< 500mg) in 8 cases. The percentage of vision recovery in high-dose corticoid group was 38.5%, with 2 cases had complications of high glycaemia (5.1%). Early treatment within 8 hours after trauma could give higher rate of recovery. Prognostic factors for no recovery included vision acuity after trauma was no light perception, 4-grade soft tissue lacerations and no response after 48 hours of high-dose corticoids. In the optic neuropathy, the rate of vision recovery in high-dose corticoid group was 38.5%, and treating by high-dose corticoids had few complications, more effective than low-dose corticoids (p<0.05)
Optic Nerve Injuries ; Therapeutics ; Steroids ; Pharmaceutical Preparations

The fourth bronchial pouch fistulae is the lesion of the fourth bronchial-pharyngeal duct in development of the embryo. 20 cases of this disease were diagnosed, operated and followed-up in the institute of ENT, from 1995 to 1997. 11 females and 9 males were affected; It manifested itself by recurrent episodes neck abscess, especially on the left side (95%). 13 fistulous tracts were found on operation with 86% of retrocartilaginous course.
Bronchial Fistula ; Pouchitis