The study was conducted on 32 HIV positive patients (24 males and 8 females, over 15 years old, with CD4 T-cell counts <350 cell/mm3) who were treated with antiretrovirus therapy (Videx and Zerit) at Dong Da Hospital from Nov 2002 to Oct 2003. The results showed that ARV therapy is effective. The weight, Kanofsky scores, and T CD4 counts of patients were increased significantly after 6 months of treatment. Side effects included fatigue, headache, nausea, but only on first week. Enzyme amylase was increased slightly after 6 months of treatment
Anti-HIV Agents ; Anti-Retroviral Agents ; HIV ; Therapeutics ; Pharmaceutical Preparations ; Retroviridae

At Viet Duc Hospital from 1998 to 1999, 50 HIV(+) intravenous drug users, aged in average 26,4 were investigated. Anti HCV serum (+) in 62%, HCV Co-infected 30% and HBV 46%, co- infected with only HBV 16%, HIV, HBV, HCV 3 viruses co- infected 32%. The co- infected incidence was 50% in the year 1998 and 66% in 1999; 22% had not HBV and HCV co- infection. HBV and HCV co-infection characteristies: hiver cell degradation in 46,65% of HIV + HCV+ HBV co- infected; 68,75% in HIV+ HCV co- infection; 87,5% in HIV+ HBV co- infection. There were no much difference in term of the number of lymphocyte and monocyte between patients of 3 virus- infection, 2 virus infection and only HIV infection
HIV ; Hepatitis B virus ; Hepacivirus ; Morphine Dependence

Background: Streptococcus pneumonia (S.pneumoniae) is the main cause of acquired pneumonia in the community along with otitis media, sinusitis, septicemia and meningitis. Objectives: The study determined antimicrobial resistance and serotype distribution of Streptococcus pneumonia isolates from hospitalized children at Hai Phong Children's Hospital, Vietnam. Subjects and method: From June 2006 to September 2007, 80 pneumococccal isolates were tested for susceptibility to the 13 antibiotics and 84 pneumococcal isolates were serotyped. Results:Seventy-five percent of strains showed multi-drug resistance. Ninety percent of strains showed resistance to penicillin (48% intermediate and 42% fully resistant). In addition, 100% of isolates were resistant to cotrimoxazole, 74% of isolates were resistant to cephalexin; 71 % of isolates were resistant to erythroomycin and 58% were resistant to cefuroxxime. Almost all the isolates were susceptible to amoxicillin, cefotaxime, ceftriaxone, ceefepime, ofloxacin and 100% of isolates were susceptible to vancomycin. Among the 84 serotypes, 82% were included in the 23 valent pneumococcal polysaccharide vaccine including: 19F (30%), 23F (21 %), 14 (13%) and 6B (13%). Six other serotypes (13, 15C, 18, 11A, 15B and 6A) accounted for 12% of strains and 9 (11%) strains were untypeable. Conclusion: Pneumococcal antibiotics is spreading most rapidly among children in Vietnam, especially strains typs 19F and 23 F. Concerted efforts are necessary to prevent it spreading.\r\n", u'\r\n', u'
Antimicrobial resistance ; streptococcus pneumonia

Diabetes, characterized by elevated blood glucose levels, has a significant impact on cardiovascular, neural, and vascular systems. α-Glucosidase inhibitors have emerged as potential therapeutic agents for type 2 diabetes, as they slow carbohydrate digestion and reduce postprandial blood sugar levels. In this study, we investigated the phytochemical and pharmacological properties of Celastrus orbiculatusThunb., renowned for its diverse phytochemical constituents and potential medicinal applications. Through the application of chromatographic and spectroscopic techniques, we successfully isolated and structurally elucidated 16 compounds from the stems of C. orbiculatus. The in vitro α-glucosidase inhibitory activity of these compounds was evaluated. Notably, celaphanol A (1) and (+) lariciresinol (7) exhibited strong α-glucosidase inhibition, with IC 50 values of 8.06 ± 0.30 and 48.02 ± 0.47 µM, respectively. Enzyme kinetics analysis revealed that the most active compound 1 acted as a non-competitive inhibitor against α-glucosidase, with a K i> value of 7.77 ± 0.16 µM. These findings underscore C. orbiculatus as a valuable source for discovering and developing new α-glucosidase inhibitors. Furthermore, compound 1 shows promise as a candidate for natural herbal therapy targeting α-glucosidase inhibition. This suggests the potential for further investigation into its effectiveness through in silico or in vivo studies using a diabetes model.