An investigation on helminth infection was conducted in the mountainous district (Quy Hop) of Nghe An province in August and September 2002 showed that: the cummulative intestinal helminth infection rate was 68.4%, with the highest rate among the people aged from 6 – 9 years. Ascaris infection rate was 54.2% with the highest rate found among people aged from 10 – 11 years. Hook worm infection rate was 28.6%, most of all were adults. Trichuris was 10.8% with no difference of ages. Single infection rate was 45.5%, mix infection rate was 23.3%, mixed infection between Ascaris and hook worm was the highest 15.7%. There was no big differences of the infection rate in sex. The intensity of intestinal helminth infection was low with average of 1431 epg for Ascaris, 864 epg for hook worm and 112 epg for Trichuris. Community living conditions and their habits were found to influences the intestinal helminth infection
Helminths ; Infection ; Disease ; epidemiology

Currently, imported malaria trend to increased and account for advantage in malaria epidemiology characteristics due to increased population changes in Nghe An province. Malaria drug management also need to changes to suit the fact that previous malaria endemic areas, where has a little malaria patients so that demand on malaria drug reduced. Domestic malaria is strongly reduced. Parasite mechanism also changes according to advantage tendency. Imported malaria appear annually and in every areas so that malaria drug need to available from the villages health station to provincial health station with 1/1 ratio for drugs against P.falciparum and P.vivax
Malaria ; Disease ; Pharmaceutical Preparations ; therapeutics ; drugs ;

In 2003, 2 small swidden field malaria outbreaks were identified in Tuong Duong district of Nghe An province. Although different development of the first time, malaria outbreaks developed in swiddenfield, then transmissed into villages. A lots of patients have confirmed to have malaria. One death case was caused by the late hospital admission. The number of working and overnight people on the swiddenfields increased at the hot spot time as this was the harvesting time and the school children had summer holiday and joined their parents’ work here (29.1 – 48.9% of household and 27.2-28.4% of population in the hamlets). They did not use mosquito nets. The infection rate of malaria among the swiddenfield people was 13.5 – 60.5% and 7.4 – 42.2%, respectively. The mass blood screen showed the presence of both P.falciparum and P.vivax (P.falciparum in Ang village and both P.falciparum and P.vivax in Phong village). A high malaria infected rate in 2 outbreaks showed a limited diagnosis and treatment’s quality of local health. Cold parasites were found to be high, with P.falciparum and combined form
Malaria ; epidemiology ; Malaria, Falciparum

The study was conducted from September 2003 to April 2005 to assess results of the mass deworming campaign in 5 primary schools in Quynh Luu district, central province of Nghe An. A pre-intervention survey showed a cumulative worm prevalence of 98%, of which the highest rate was Trichuris infection: 85.1% followed by Ascaris: 83.6% and hookworm 30.3%. No difference of infection between females and males was found. Mixed infection was high with 54.3% had co-infection with Ascaris and Trichuris (88%), and 24.8% had triple infection, while a low single infection rate (20.8%) of which Trichuris was predominant, was found. A low prevalence of high intensity of infections was found with Ascaris (6.5%), hookworm (1 %), Trichuris (0.5%) while a high prevalence of low intensity was found with all examined samples. The worm prevalence was found reduced after periodical mass deworming (every six months) with mebendazole 500mg, single dose. The cumulative infection reduced from 98% to 84.5% after six months and 72.2% after 18 months. Similarly, the Ascaris infection came down from 83.6% to 52.7% and 32.7%, the Trichuris from 85.1% to 70.6% and 56.1%. However, hookwonn infection remained nearly unchanged (30.3% to 31.3% and 31.1 %). The high and moderate intensity of infection was also reduced after intervention. The egg counts were reduced by 60% after 6 months, 73% after 18 months (after the third treatment) with Ascaris. Accordingly, it was reduced by 40% and 70%, respectively with Trichuris. No changes were found with hookwonn. The intestinal wonn infection control project supported by WHO has been a successful project in tenn of both technical and social aspects. The project was performed with good compliance of school children, their parents and teachers. Expertise and qualification of the provincial staffs were also enhanced with regard to public health in general, and intestinal worm infection control, in particular.
Helminths ; Mebendazole ; Therapeutics

Malaria situation in DakLak province in the first 5 months of 2003 has increased highly and unstable. High morbidity of malaria is concentrated in five districts of DakLak province: DakRlap, DakNong, DakSong, M’dRak and DakMil. These are far, newly established districts with very difficult conditions of transport, economy and numerous problems caused by the illegal migration of population. The most of local inhabitants of mainly districts are protected by insecticide such as house spraying or bednet impregnation with covering 80-90%. The vector control method now is practiced better but these activities mainly aimed at protecting the local inhabitant clusters or stably settled people while ignored the new settlers and people who frequently stay overnight in the swidden fields
Malaria ; Disease ; Solutions

The sub-chronic toxicity of an antimalaria combination between piperaquine phosphate (PQP) and dihydroartemisinin (DHA) at the doses of 64 and 100 mg of (PQP+DHA)/kg of body weight/day for 28 consecutive days in rabbits was investigated in this study. Results: rabbits acted and ate normally. At the doses of 64 mg of (PQP+DHA)/kg/day x 28 consecutive days, the body weights of rabbits increased statistical significantly at day N28 compared to days before using the combination (p<0.05). At the doses of (PQP+DHA) 100 mg/kg/day x 28 consecutive days, the weights of rabbits increased statistically at day 14 and 28. At dose of 64 mg PQP+DHA/kg/day x 28 day, biochemical indicators (SGOT, SGPT, creatinin, protein and bilirubin) and hematological indicators (erythrocytes, leukocytes, leukocyte formula and hemoglobin) did not change significantly (p>0.05) after 28 days. At dose of 100 mg PQP+DHA/kg/day x 28 days, biochemical indicators (SGOT, SGPT, creatinin, protein and bilirubin) and hematological indicators (hemoglobin, erythrocytes, leukocytes, neutrophils and lymphocytes) did not change significantly (p>0.05) after 28 days but protein and monocytes increased significantly (p<0.05) on day 28
Malaria ; Therapeutics ; Artemisinins

Study on dental carries situation of 200 pupils at 6 secondary schools in Hai Duong city. Results: The rate of dental carries of 12 years old pupils was high (67%), in the 6th teeth was 63%. 80.5% of pupils had good knowledge of oral hygiene and 74.5% had good practice of oral hygiene. School based oral health program is strongly supported and collaborated by the leaders of schools. It is necessary to develop human resource for school based oral health program, and the teachers should be trained for co-operation and participation this program.
Dental Caries ; Hygiene ; Pupil

Evaluation of effectiveness of house spraying with Ale 10SC/m2 in malaria mosquitoe prevention by testing bioassay and etomological indicators as well as side effects in the community in implemented area from 11/2003-11/2004 at Quyet Chien commune, Tan Lac District, Hoa Binh province shows that using Ale 10SC spraying with 30mm/m2 with 6 months of residual on wooden and brick wall and the mosquitoe death rate is 51.3-52.6%. Ale 10SC spraying decreased the density of An.minimus domestically daytime and seeking blood. Ale 10SC spraying with 30mg/m2 in malaria transmitted mosquitoes does not have side effects on people using it directly and the community
Malaria ; Culicidae ; Pyrethrins

The sub-chronic toxicity of piperaquine phosphate was assessed in rabbits. Piperaquine phosphate (PQP), at the doses of 50 and 100 mg/kg of body weight per day for 28 consecutive days, was administered orally. The influences of PQP on rabbits' laboratory indices were observed during the PQP administration and after the treatment. Rabbits treated with PQP by oral administration were found to have normal action dinning. At the dose of 50mg/kg per day for 28 consecutive days, the body weights of rabbits was increased significantly during study period (p<0.05), but was not changed significantly at the dose of 100 mg/kg per dayx 28 days. PQP, at the dose of 50 mg/kg per day for 28 consecutive days, did not change significantly biochemical indices (SGOT,SGPT, bilirubin and protein) and some hematological indices (leukocytes, leukocyte formula and hemoglobin), but significantly increased erythrocytes and creatinine on days 14 and 28. At the treated dose 100mg/kg per dayx28days, biochemical indices (SGOT, protein) and some hematological indices (erythrocytes, leukocytes and leukocyte formula) did not change significantly during study period, but creatinine, bilirubin and SGPT were significantly changed
Animal Experimentation ; Rabbits

The study was designed to evaluate the effectiveness of bed-net impregnation with Ale l0SC at a dose 25mg a.i/m2 based on bioassays, entomological indices and to evaluate side effects and the influence of washing of bed-nets in terms of insecticide residual effects. The trials were conducted from November 2003 to November 2004 in Quyet Chien commune, Hoa Binh province's Tan Lac district. Polyester bed-nets impregnated with Ale l0SC at dose of 25mg ai/m2 were found to have 6-month residual effects and to remain effective in malaria vector control after one wash (60 days after treatment). Ale l0SC bed-net impregnation were found to reduce the density of day time indoor resting and human biting anopheline mosquitoes. There are unsignficant side effects among spraymen, dippers and villagers in the treatment areas caused by bed-net impregnation at dose of 25mg ai/m2 were observed.
Malaria ; Pyrethrins