Osteogenesis imperfecta is an inherited disorder of collagen with skeletal and extraskeletal manifestations that affect airway and anesthetic management of patients with the disease. This paper aimed to report a case of a patient with osteogenesis imperfecta for abdominal hysterectomy, discuss the anesthetic considerations of patients with the disease, describe balanced anesthesia using high dose dexmedetomidine as a primary agent and, use of ProSeal LMA for airway management. A 44- year old female with osteogenesis imperfecta is scheduled for abdominal hysterectomy for molar pregnancy. Airway management was achieved with a ProSeal LMA, and surgery was conducted using balanced anesthesia with high dose dexmedetomidine, midazolam, fentanyl, atracurium and O2- nitrous oxide. Dexmedetomidine was given at concentrations ranging from 0.7 mcg/kg/hr to 3mcg/kg/hr without untoward adverse effects. No complications were observed intraoperatively and in the immediate postoperative period. Dexmedetomidine is demonstrated to be safe and effective when used as part of a balanced anesthesia for patients with osteogenesis imperfecta. Likewise, the airway can be reliably managed with the use of a ProSeal LMA.
Human ; Female ; Adult ; OSTEOGENESIS IMPERFECTA ; DEXMEDETOMIDINE ; ANESTHESIA ; AIRWAY MANAGEMENT