PURPOSE: . The study objective was to evaluate the influence of the type of resin cement on the flexural strength and load to fracture of two chairside CADCAM materials after aging. MATERIALS AND METHODS: . A polymer-infiltrated ceramic network (PICN) and a nanoceramic resin (RNC) were used to produce the specimens. Two types of dual-cure resin cements, a self-adhesive and a universal, were investigated. Bilayer specimens were produced (n = 10) and aged for 6 months in a humid environment before the biaxial flexural strength test (σ f ).Bonded specimens were subjected to a mechanical aging protocol (50 N, 2 Hz, 37°C water, 500,000 cycles) before the compressive load test (L f ). σ f and L f data were analyzed using two-way ANOVA and Tukey tests (α = .05). Chi-square test was used to analyze the relationship between failure mode and experimental group (α = .05). RESULTS: . The type of resin cement and the interaction between factors had no effect on the σ f and L f of the specimens, while the type of restorative material was significant. RNC had higher σ f and L f than PICN. There was a significant association among the type of cracks identified for specimens tested in L f and the restorative material. CONCLUSION . The type of resin cement had no effect on the flexural strength and load to fracture of the two investigated CAD-CAM chairside materials after aging. [J Adv Prosthodont 2023;15:136-44]