No Abstract Available.
Latex Hypersensitivity* ; Latex* ; Operating Rooms*

Allergy to latex gloves has been described as an unusual complication during labor. However, IgE mediated hypersensitivity reaction to natural rubber have recently been identified as an international health problem. In this first case report in Korea, latex anaphylaxis during labor is described in an operating room nurse who has been continuously exposed to latex gloves. Because of the increasing frequency of latex allergy, obstetrician should take care and give more attention to the clinical history, as well as be aware of this possibility especially in high risk groups.
Anaphylaxis* ; Hypersensitivity ; Hypersensitivity, Immediate ; Korea ; Latex Hypersensitivity ; Latex* ; Operating Rooms ; Rubber ; World Health

Latex is the milky sap obtained by tapping the rubber tree, Hevea brasiliensis. The prevalence of latex allergy has been on the increase alongside the wider use of latex-manufactured products. The number of reports of latex-induced anaphylaxis during operation is therefore increasing. We report the case of a 56-year-old male patient who developed severe anaphylactic shock while under anesthesia when the tourniquet was deflated during elbow arthrolysis. A subsequent allergy workup revealed an IgE-mediated hypersensitivity to latex.
Anaphylaxis ; Anesthesia ; Elbow ; Hevea ; Humans ; Hypersensitivity ; Hypersensitivity, Immediate ; Latex ; Latex Hypersensitivity ; Male ; Middle Aged ; Prevalence ; Tourniquets

The prevalence of latex allergies has been on the increase along with the greater use of rubber products in daily life, medical, dental and occupational settings. Allergic reactions to latex can take two clinical forms of either contact dermatitis or immediate hypersensitivity reactions, which are provoked by the natural latex proteins or chemical additives used in the manufacturing process, respectively. A 25-year-old female, an operating room nurse, complained of recurrent pruritic erythematous wheals on both hands after the wearing of latex rubber gloves. The prick test and the usage Mlit't to the latex gloves were positive, and the RAST was class 3. To the best of our knowledge, is the first case report of contact urticaria from latex rubber gloves in Korean dermatologic literature.
Adult ; Dermatitis, Contact ; Female ; Hand ; Humans ; Hypersensitivity ; Hypersensitivity, Immediate ; Latex Hypersensitivity ; Latex* ; Operating Rooms ; Prevalence ; Rubber ; Urticaria*

BACKGROUND: Natural rubber latex has become an important health concern in recent years, particularly in risk groups. Atopic dermatitis is well known risk factor for latex allergy, but there is no data or study of latex allergy in Korea. OBJECTIVE: The purpose of this study was to investigate the prevalence of latex sensitization in atopic dermatitis patients. METHODS: A total of 154 patients presenting with various diseases for allergologic evaluation was studied. A questionnaire-based history was taken, skin prick tests(SPT) with latex glove extract were done. In SPT positive patients, serum total IgE and latex-specific IgE by radioallergosorbent test(RAST) were measured, and a use test was also performed. RESULTS: A total of 77 subjects(50%) was atopic. There were positive SPT reactions to latex in 13/77(16.9%). There were only 7 positive to the latex RAST in SPT positive patients. Except one patient, there were no clinically relevant latex allergy by history and challenge tests. CONCLUSION: The results of this study suggest that the prevalence of latex sensitization in atopic dermatitis patients is quite high(16.9%), and in latex allergy diagnosis, SPT is more sensitive than RAST.
Dermatitis, Atopic* ; Diagnosis ; Humans ; Immunoglobulin E ; Korea ; Latex Hypersensitivity ; Latex* ; Prevalence* ; Risk Factors ; Rubber ; Skin*

Vaccine contains active components, adjuvants, stabilizers, preservatives, and trace components. Adverse reactions to vaccines are rarely reported. However, all of vaccine components may elicit adverse reaction including life-threatening event in susceptible individuals, therefore raising concerns regarding safety of vaccine still continue up to date. Hypersensitivity reaction to vaccines can be classified as allergic reaction to the vaccine component, pseudo-allergic reaction, and exacerbation of allergic diseases. Hypersensitivity reactions to vaccine components rarely occurred in the population-level, while severe hypersensitivity reaction such as anaphylaxis may be consequent result in susceptible individuals. Some of components such as ovalbumin, gelatin, yeast, and latex were considered as common causes of allergic reactions to the vaccine. However, the incidence or causes of vaccine related hypersensitivity reaction in Korea were not well known. The aims of this article are to review the literatures with hypersensitivity reactions related with vaccine components, to provide detailed information about major components of vaccines commonly used in Korea, and to provide the best way of vaccination in susceptible individuals.
Anaphylaxis ; Gelatin ; Hypersensitivity* ; Incidence ; Korea ; Latex ; Ovalbumin ; Vaccination ; Vaccines ; Yeasts

Adverse reactions to latex are various from localized skin problem to systemic anaphylaxis, even causing death. There are few reports on latex glove hypersensitivity in Korea, even though clinically the adverse reactions to latex sporadically have been reported. The purpose of this study was to survey the prevalence rate of adverse reactions to latex glove and compare the rate of allergy to ordinary latex glove with those 4 types of hypoallergenic gloves. Data on adverse reaction to latex gloves and symptoms as well as risk factors were collected from 63 operating room nurses using a questionnaire and direct observation of skim prick test. Questionnaire was used to survey the adverse reactions including the type I and IV, skin prick test was used to survey latex allergy defined type I. Among respondents, 25 nurses with adverse reaction to latex gloves were selected for the skin prick and exposure test with 5 latex gloves ( 1 ordinary glove, 4 hypoallergenic gloves) using the repeated measures design of the counterbalancing method. The results were followed : 1) The response rate of questionnaire was 96.8%, and the prick test was performed in 61 out of 63 nurses. 2) Common symptoms of adverse reactions to latex gloves were rash (49.2%), skin itching (44.3%), dizziness (31.3%), and eye itching (26.2%). 3) The prevalence rate of adverse reactions to latex glove was 80.3%. 4) The prevalence rate of latex allergy was 9.8%. The relationship between the latex allergy and atopy was significant, i.e. the atopic persons had more latex allergy than the non-atopics. 5) In 5 latex gloves, the prevalence rate of latex allergy by skin prick test and skin exposure test was follows : 16%, 24% for skin angel gloves, 8%, 24% for hypoallergenic HAG glove, 12%, 4% for hypoallergenic SmooTer-R glove, 8%, 0% for hypoallergenic Candle glove, 8%, 24% for hypoallergenic Neutralon glove respectively. There was no difference in prevalence rate of latex allergy among gloves by skin prick test. As the results of skin exposure test, the usual latex gloves had higher prevalence rate of latex allergy than the hypoallergenic gloves (p<0.0001).
Anaphylaxis ; Dizziness ; Exanthema ; Humans ; Hypersensitivity ; Korea ; Latex Hypersensitivity ; Latex* ; Operating Rooms ; Prevalence ; Pruritus ; Risk Factors ; Skin ; Surveys and Questionnaires

The prevalence of rubber allergies has been on the increase along with the greater use of rubber products in daily life, medical, dental and occupational settings. Rubber allergy can be divided into two types, type I immediate allergy to rubber latex and type IV delayed allergic reaction to rubber chemical additives or rubber latex itself. A 43-year-old male admitted for lung cancer. He had complained of pruritic linear erythematous plaque at the contact site on the right forearm in the rubber portion of fluid extension tube after one day. The prick test and the usage test were negative. Patch test with Korean standard patch test, rubber additive series, 'as is' were performed. The results were positive for chemical additives for rubber; tetramethylthiuram disulfide, tetramethylthiuram monosulfide, tetraethylthiuram disulfide, dipentamethylenethiuram disulfide, N-cyclohexyl-4-phenyl-4-phenylenediamine, N-isopropyl-N-phenyl-4-phenylenediamine, 2-mercaptobenzothiazole, N-cyclohexyl benzothiazyl sulphenamide, morpholinyl mercaptobenzothiazole and 'as is'. We report herein a case of allergic contact dermatitis due to rubber chemical additives contained in the rubber portion of the fluid extension tube.
Adult ; Dermatitis, Allergic Contact* ; Disulfiram ; Forearm ; Humans ; Hypersensitivity ; Latex ; Latex Hypersensitivity ; Lung Neoplasms ; Male ; Patch Tests ; Prevalence ; Rubber* ; Thiram

The reports of adverse reactions related to latex glove use increase worldwidely. There is no clear cause. The adverse reactions related to latex glove are reported variously from localized minimal to systemic anaphylaxis, even death. There is no report on latex glove hypersensitivity in Korea, but clinically we have heard the adverse reactions sporadically. Therefore this investigators survey operating room nurses and surgeons who are high risk groups. The study will be the basis on latex allergy. We can explore alternatives against latex glove allergy through the study. Data are collected 210 respondents(doctors, 147 ; nurses, 63) by the questionnaire from July 8 to September 22 in 1995 and analyzed by descriptive statistics. Conclusions are follows : (1) Incidence of adverse reaction related to latex glove use is total 41.0%(87 person), which include 35 nurses(55.6%) and 52 doctors(35.4%). (2) The relation between the incidence and exposure time is significant, those who are working in operating room more than 5 years have higher incidence(p=0.005). (3) The relation between the incidence and gender is significant, and the incidence in female is higher. (4) The atopic persons have more adverse reactions than the non-atopics(p=0.00005). (5) There is no relation between the incidence and disease history(p=0.37). (6) Common adverse reactions include itching(90.8%), rash(71.3%), dermatitis(52.9%), urticaria(35.6%), relatively rate adverse reactions include facial edema, dyspnea, wheezing, fainting and so on. (7) In surgical general gloves the adverse reaction incidence is 41.0%(87/210), in hypoallergenic glove, 47.8(11/23). In conclusion, the adverse reaction incidence related to surgical latex glove are 41.0%, gloves used in this study are 2 types, to which persons having adverse reactions are 11.
Anaphylaxis ; Dyspnea ; Edema ; Female ; Humans ; Hypersensitivity ; Incidence ; Korea ; Latex Hypersensitivity ; Latex* ; Operating Rooms ; Research Personnel ; Respiratory Sounds ; Syncope ; Surveys and Questionnaires

This study was conducted to determine the prevalence rate of adverse reactions to latex gloves. The study compared allergic reactions to ordinary latex gloves with four types of hypoallergenic gloves among operating room nurses at a teaching hospital in Seoul, Korea. Data were collected from 63 operating room nurses by a questionnaire and direct observation of a skin prick test. Among respondents, 25 nurses with adverse reactions to latex gloves were selected for the skin prick and exposure tests with five latex gloves (1 ordinary glove, and 4 hypoallergenic gloves) using a repeated measures design of counterbalancing method. Study Results are as follows: (1) The response rate of the questionnaire was 96.8%, and the prick test was performed in 61 out of 63 nurses. (2) Common symptoms of allergic reactions to latex gloves were rash (49.2%), skin itching (44.3%), dizziness (31.1%), and eye itching (26.2%). (3) The prevalence rate of adverse reactions was 80.3%, and that of latex allergy was 9.8%. (4) Atopic subjects had more latex allergy than the non-atopics. (5) There was no difference in the incidence rate of latex allergy among the five gloves by the skin prick test. But with the skin exposure test, ordinary latex gloves had a higher incidence rate of latex allergy than the hypoallergenic gloves (p<0.0001).
Surveys and Questionnaires ; Dizziness ; Exanthema ; Hospitals, Teaching ; Hypersensitivity ; Incidence ; Korea* ; Latex Hypersensitivity ; Latex* ; Operating Rooms ; Prevalence ; Pruritus ; Seoul ; Skin