2.A Cross-Cultural Study on Psychosocial Risk Factors of Adolescent Depression between Koreans and Korean-Russians.
Dong Ho SONG ; Hong Shick LEE ; Larissa KIM ; Chan Hyung KIM ; Ji Woong KIM ; Sung Kil MIN
Journal of Korean Neuropsychiatric Association 1999;38(5):944-955
OBJECTIVES: In order to study a cross-cultural epidemiology of the adolescent depressives with Korean ethnicity in Korea and Russia, we compared psychosocial characteristics and risk factors of depressive disorder between two school-based populations in different sociocultural environments. METHODS: We measured psychosocial variables of 838 subjects in Korea, and 652 in Russia (Uzbekitan) using Basic Questionnaires and Beck Depression Inventory (BDI) RESULTS: The cut-off point of BDI for adolescent depression in Koreans was 19 points. Higher prevalence of depression was noted in Korean adolescents (26.5%)compared to Korean-Russian adolescents (7.4%) We found signicant risk factors of adolescent depression in two study samples: female, academic failure, meeting friends less frequently, presence of chronic physical illness, interpersonal problems with parents, and same-sex and opposite-sex friends. CONCLUSIONS: Our data will provide information on cross-cultural understanding of psychosocial characteristics and risk factors in adolescent depression compared between Koreans and Korean-Russians.
Adolescent*
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Depression*
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Depressive Disorder
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Epidemiology
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Female
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Friends
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Humans
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Korea
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Parents
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Prevalence
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Surveys and Questionnaires
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Risk Factors*
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Russia
3.Prevention of Prostate Cancer in Transgenic Adenocarcinoma of the Mouse Prostate Mice by Yellow Passion Fruit Extract and Antiproliferative Effects of Its Bioactive Compound Piceatannol
Larissa Akemi KIDO ; Eun-Ryeong HAHM ; Su-Hyeong KIM ; Andressa Mara BASEGGIO ; Valeria Helena Alves CAGNON ; Shivendra V. SINGH ; Mário Roberto MARÓSTICA JR.
Journal of Cancer Prevention 2020;25(2):87-99
Piceatannol (PIC), a polyphenol presents in many vegetables and fruits including yellow passion fruit extract (PFE; Passiflora edulis), has anti-cancer activity, but its molecular targets are still poorly understood. The aims of this study were to investigate the molecular mechanistic actions of PIC in prostate cancer cell lines and to test if the extract from PFE rich in PIC can affect the growth of prostate cancer cells in the Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model. The PC-3, 22Rv1, LNCaP, and VCaP prostate cancer cells were exposed to PIC (10-40 μM), and cell viability, lactate measurement, Western blot, and flow cytometric analyses were performed. For an in vivo experiments, eight-week-old TRAMP mice (n = 10 per group each) received an aqueous extract of PFE containing 20 mg of PIC/kg or water (control group) by gavage for 4 or 10 weeks for further analyses. PIC treatment concentration- and time-dependently reduced viability of all cell lines tested. 22Rv1 and LNCaP cells treated with PIC did not exhibit any significant alteration in the intracellular accumulation of lactate. PIC treatment caused G0/G1 phase cell cycle arrest and induction of apoptosis in both LNCaP and 22Rv1 cells. PIC-treated cells exhibited altered protein levels of p53, p21, cyclin D1, and cyclin-dependent kinase 4 (cdk4). The short and long-term PFE treatments also affected p21, cyclin D1 and cdk4 and delayed disease progression in TRAMP, with a decreased incidence of preneoplastic lesions. In conclusion, PIC apparently does not alter glucose metabolism in prostate cancer cells, while cell cycle arrest and p53 modulation are likely important in anti-cancer effects of PIC alone or as a food matrix byproduct in prostate cancer cells, especially those with an androgen-dependent phenotype.